Prognostic significance of p16 expression in advanced cervical cancer treated with definitive radiotherapy

International Journal of Radiation Oncology Biology Physics

Volumn 84, Issue 1, 2012, Pages 153-157

  Schwarz, Julie K ^a,b,c   Lewis Jr , James S ^b,c   Pfeifer, John ^b,c   Huettner, Phyllis ^b   Grigsby, Perry ^a,b,c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Washington University in St Louis School of Medicine   (United States)

Author keywords

Biomarker; Cervix; HPV; p16; Radiation

Indexed keywords

CAUSE-SPECIFIC SURVIVAL; CERVICAL CANCERS; CERVICAL CARCINOMA; CERVIX; CHEMORADIATION; CONCURRENT CISPLATIN; DEFINITIVE RADIOTHERAPY; FDG-PET; FLUORODEOXYGLUCOSE-POSITRON EMISSION TOMOGRAPHIES; HPV; IMMUNOHISTOCHEMISTRY; INTERNATIONAL FEDERATION; MEAN AGES; P16; PROGNOSTIC SIGNIFICANCE; RECURRENCE-FREE SURVIVAL; TISSUE MICROARRAYS; TOMOGRAPHS;

BIOMARKERS; CHEMOTHERAPY; HEAT RADIATION; MONOCLONAL ANTIBODIES; PARAFFINS; PLATINUM COMPOUNDS; POSITRON EMISSION TOMOGRAPHY; RADIOTHERAPY; TUMORS;

DIAGNOSIS;

CISPLATIN; FLUORODEOXYGLUCOSE F 18; MONOCLONAL ANTIBODY; PARAFFIN; PEROXIDASE; PROTEIN P16;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BIOPSY; CANCER CHEMOTHERAPY; CANCER DIAGNOSIS; CANCER INVASION; CANCER PATIENT; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER SURVIVAL; CONTROLLED STUDY; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPEROXIDASE STAINING; MAJOR CLINICAL STUDY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENT LARYNGEAL NERVE PALSY; RETROSPECTIVE STUDY; TISSUE MICROARRAY; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CISPLATIN; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NEOPLASM PROTEINS; PROGNOSIS; RADIATION-SENSITIZING AGENTS; RETROSPECTIVE STUDIES; TISSUE ARRAY ANALYSIS; UTERINE CERVICAL NEOPLASMS;

EID: 84865689287     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.11.032     Document Type: Article

References (28)

1. C. Fakhry, W.H. Westra, and S. Li Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial J Natl Cancer Inst 100 2008 261 269
2. F.P. Worden, B. Kumar, and J.S. Lee Chemoselection as a strategy for organ preservation in advanced oropharynx cancer: Response and survival positively associated with HPV16 copy number J Clin Oncol 26 2008 3138 3146
3. A.R. Sedaghat, Z. Zhang, and S. Begum Prognostic significance of human papillomavirus in oropharyngeal squamous cell carcinomas Laryngoscope 119 2009 1542 1549
4. W. Shi, H. Kato, and B. Perez-Ordonez Comparative prognostic value of HPV16 E6 mRNA compared with in situ hybridization for human oropharyngeal squamous carcinoma J Clin Oncol 27 2009 6213 6221
5. C.C. Ragin, and E. Taioli Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: Review and meta-analysis Int J Cancer 121 2007 1813 1820
6. C.T. Allen, J.S. Lewis Jr., and S.K. El-Mofty Human papillomavirus and oropharynx cancer: Biology, detection and clinical implications Laryngoscope 120 2010 1756 1772
7. K.K. Ang, J. Harris, and R. Wheeler Human papillomavirus and survival of patients with oropharyngeal cancer N Engl J Med 363 2010 24 35
8. J.T. Rich, S. Milov, and J.S. Lewis Jr. Transoral laser microsurgery (TLM) +/- adjuvant therapy for advanced stage oropharyngeal cancer: Outcomes and prognostic factors Laryngoscope 119 2009 1709 1719
9. N. Reimers, H.U. Kasper, and S.J. Weissenborn Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer Int J Cancer 120 2007 1731 1738
10. H.C. Hafkamp, E.J. Speel, and A. Haesevoets A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5-8 Int J Cancer 107 2003 394 400
11. B. Kumar, K.G. Cordell, and J.S. Lee EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer J Clin Oncol 26 2008 3128 3137
12. S. de Sanjose, W.G. Quint, and L. Alemany Human papillomavirus genotype attribution in invasive cervical cancer: A retrospective crosssectional worldwide study Lancet Oncol 11 2010 1048 1056
13. T. Yamazaki, S. Tomita, and K. Ichikawa P16-immunostaining pattern as a predictive marker of lymph node metastasis and recurrence in early uterine cervical cancer Pathobiology 73 2006 176 182
14. R. Gupta, R. Srinivasan, and R. Nijhawan Protein p 16INK4A expression in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of uterine cervix Indian J Pathol Microbiol 53 2010 7 11
15. C. Queiroz, T.C. Silva, and V.A. Alves P16(INK4a) expression as a potential prognostic marker in cervical pre-neoplastic and neoplastic lesions Pathol Res Pract 202 2006 77 83
16. A.P. Lambert, F. Anschau, and V.M. Schmitt p16INK4A expression in cervical premalignant and malignant lesions Exp Mol Pathol 80 2006 192 196
17. M.M. Finegan, A.C. Han, and M.I. Edelson p16 expression in squamous lesions of the female genital tract J Mol Histol 35 2004 111 114
18. I. Tsoumpou, M. Arbyn, and M. Kyrgiou p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: A systematic review and meta-analysis Cancer Treat Rev 35 2009 210 220
19. H. Masoudi, D.J. Van Niekerk, and C.B. Gilks Loss of p16 INK4 expression in invasive squamous cell carcinoma of the uterine cervix is an adverse prognostic marker Histopathology 49 2006 542 545
20. J.K. Schwarz, B.A. Siegel, and F. Dehdashti Association of posttherapy positron emission tomography with tumor response and survival in cervical carcinoma JAMA 298 2007 2289 2295
21. J.F. Delaloye, S. Pampallona, and P.A. Coucke Younger age as a bad prognostic factor in patients with carcinoma of the cervix Eur J Obstet Gynecol Reprod Biol 64 1996 201 205
22. M.J. Dattoli, H.F. Gretz 3rd, and U. Beller Analysis of multiple prognostic factors in patients with stage IB cervical cancer: Age as a major determinant Int J Radiat Oncol Biol Phys 17 1989 41 47
23. C.A. Meanwell, K.A. Kelly, and S. Wilson Young age as a prognostic factor in cervical cancer: Analysis of population based data from 10,022 cases Br Med J (Clin Res Ed) 296 1988 386 391
24. F.N. Rutledge, M.F. Mitchell, and M. Munsell Youth as a prognostic factor in carcinoma of the cervix: A matched analysis Gynecol Oncol 44 1992 123 130
25. P.A. Mitchell, S. Waggoner, and J. Rotmensch Cervical cancer in the elderly treated with radiation therapy Gynecol Oncol 71 1998 291 298
26. M.L. Gillison, G. D'Souza, and W. Westra Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers J Natl Cancer Inst 100 2008 407 420
27. S. Marur, G. D'Souza, and W.H. Westra HPV-associated head and neck cancer: A virus-related cancer epidemic Lancet Oncol 11 2010 781 789
28. N.F. Schlecht, M. Brandwein-Gensler, and G.J. Nuovo A comparison of clinically utilized human papillomavirus detection methods in head and neck cancer Mod Pathol 24 2010 1295 1305