Cell-free serum DNA in patients with bladder cancer: Results of a prospective multicenter study

Anticancer Research

Volumn 32, Issue 8, 2012, Pages 3119-3124

  Hauser, Stefan ^a   Kogej, Monika ^a   Fechner, Guido ^a   Von Ruecker, Alexander ^a   Bastian, Patrick J ^b   Von Pezold, Jochen ^c   Vorreuther, Roland ^d   Lümmen, Gerd ^e   Müller, Stefan C ^a   Ellinger, Jörg ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c Katholische Kliniken Oberberg gGmbH   (Germany)

^d Evangelische Kliniken Bonn   (Germany)

^e St Josef Hospital Troisdorf   (Germany)

Author keywords

ACTB; Bladder cancer; Cell free DNA; Diagnosis; Transurethral bladder resection

Indexed keywords

BETA ACTIN; CELL FREE DNA; DNA; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BLADDER CANCER; CANCER PATIENT; CANCER SURGERY; DNA INTEGRATION; FEMALE; HISTOLOGY; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NON MUSCLE INVASIVE BLADDER CANCER; PRIORITY JOURNAL; PROSPECTIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; TRANSURETHRAL BLADDER RESECTION; TRANSURETHRAL RESECTION;

ADULT; AGED; BASE SEQUENCE; CASE-CONTROL STUDIES; CELL-FREE SYSTEM; DNA; DNA PRIMERS; FEMALE; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; REAL-TIME POLYMERASE CHAIN REACTION; URINARY BLADDER NEOPLASMS;

EID: 84865682666     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Mandel P and Metais P: Les acides nucleiques du plasma sanguine chez l'homme. C R Acad Sci Paris 142: 241-243, 1948.
2. Chang HW, Lee SM, Goodman SN, Singer G, Cho SK, Sokoll LJ, Montz FJ, Roden R, Zhang Z, Chan DW, Kurman RJ and Shih I: Assessment of plasma DNA levels, allelic imbalance, and CA 125 as diagnostic tests for cancer. J Natl Cancer Inst 94: 1697-1703, 2002.
3. Polcher M, Ellinger J, Willems S, El Maarri O, Holler T, Amann C, Wolfgarten M, Rudlowski C, Kuhn W and Braun M: Impact of the menstrual cycle on circulating cell-free DNA. Anticancer Res 30: 2235-2240, 2010.
4. Gautschi O, Bigosch C, Huegli B, Jermann M, Marx A, Chasse E, Ratschiller D, Weder W, Joerger M, Betticher DC, Stahel RA and Ziegler A: Circulating deoxyribonucleic Acid as prognostic marker in non-small-cell lung cancer patients undergoing chemotherapy. J Clin Oncol 22: 4157-4164, 2004.
5. Ellinger J, Haan K, Heukamp LC, Kahl P, Buttner R, Muller SC, von Ruecker A and Bastian PJ: CpG Island hypermethylation in cell-free serum DNA identifies patients with localized prostate cancer. Prostate 68: 42-49, 2008.
6. de Martino M, Klatte T, Haitel A and Marberger M: Serum cell-free DNA in renal cell carcinoma: a diagnostic and prognostic marker. Cancer 118: 82-90, 2012.
7. Sai S, Ichikawa D, Tomita H, Ikoma D, Tani N, Ikoma H, Kikuchi S, Fujiwara H, Ueda Y and Otsuji E: Quantification of plasma cell-free DNA in patients with gastric cancer. Anticancer Res 27: 2747-2751, 2007.
8. Tomita H, Ichikawa D, Ikoma D, Sai S, Tani N, Ikoma H, Fujiwara H, Kikuchi S, Okamoto K, Ochiai T and Otsuji E: Quantification of circulating plasma DNA fragments as tumor markers in patients with esophageal cancer. Anticancer Res 27: 2737-2741, 2007.
9. Bastian PJ, Palapattu GS, Yegnasubramanian S, Lin X, Rogers CG, Mangold LA, Trock B, Eisenberger M, Partin AW and Nelson WG: Prognostic value of preoperative serum cell-free circulating DNA in men with prostate cancer undergoing radical prostatectomy. Clin Cancer Res 13: 5361-5367, 2007.
10. Umetani N, Giuliano AE, Hiramatsu SH, Amersi F, Nakagawa T, Martino S and Hoon DS: Prediction of breast tumor progression by integrity of free circulating DNA in serum. J Clin Oncol 24: 4270-4276, 2006.
11. Umetani N, Kim J, Hiramatsu S, Reber HA, Hines OJ, Bilchik AJ and Hoon DS: Increased integrity of free circulating DNA in sera of patients with colorectal or periampullary cancer: direct quantitative PCR for ALU repeats. Clin Chem 52: 1062-1069, 2006.
12. Hauser S, Zahalka T, Ellinger J, Fechner G, Heukamp LC, von Ruecker A, Muller SC and Bastian PJ: Cell-free circulating DNA: Diagnostic value in patients with renal cell cancer. Anticancer Res 30: 2785-2789, 2010.
13. Ellinger J, Bastian PJ, Haan KI, Heukamp LC, Buettner R, Fimmers R, Mueller SC and von Ruecker A: Noncancerous PTGS2 DNA fragments of apoptotic origin in sera of prostate cancer patients qualify as diagnostic and prognostic indicators. Int J Cancer 122: 138-143, 2008.
14. Ellinger J, Wittkamp V, Albers P, Perabo FG, Mueller SC, von Ruecker A and Bastian PJ: Cell-free circulating DNA: diagnostic value in patients with testicular germ cell cancer. J Urol 181: 363-371, 2009.
15. Ellinger J, Bastian PJ, Ellinger N, Perabo FG, Buettner R, Mueller SC and von Ruecker A: Apoptotic DNA fragments in serum of patients with muscle invasive bladder cancer: A prognostic entity. Cancer Lett 264: 274-280, 2008.
16. Kohler C, Barekati Z, Radpour R and Zhong XY: Cell-free DNA in the circulation as a potential cancer biomarker. Anticancer Res 31: 2623-2628, 2011.
17. Ellinger J, El Kassem N, Heukamp LC, Mathews S, Cubukluoz F, Kahl P, Perabo FG, Muller SC, von Ruecker A and Bastian PJ: Hypermethylation of cell-free serum DNA indicates worse outcome in patients with bladder cancer. J Urol 179: 346-352, 2008.
18. Gormally E, Hainaut P, Caboux E, Airoldi L, Autrup H, Malaveille C, Dunning A, Garte S, Matullo G, Overvad K, Tjonneland A, Clavel-Chapelon F, Boffetta P, Boeing H, Trichopoulou A, Palli D, Krogh V, Tumino R, Panico S, Bueno-de-Mesquita HB, Peeters PH, Lund E, Gonzalez CA, Martinez C, Dorronsoro M, Barricarte A, Tormo MJ, Quiros JR, Berglund G, Hallmans G, Day NE, Key TJ, Veglia F, Peluso M, Norat T, Saracci R, Kaaks R, Riboli E and Vineis P: Amount of DNA in plasma and cancer risk: a prospective study. Int J Cancer 111: 746-749, 2004.
19. Chan KC, Yeung SW, Lui WB, Rainer TH and Lo YM: Effects of preanalytical factors on the molecular size of cell-free DNA in blood. Clin Chem 51: 781-784, 2005.