Cell-Free Circulating DNA: Diagnostic Value in Patients With Testicular Germ Cell Cancer

Journal of Urology

Volumn 181, Issue 1, 2009, Pages 363-371

  Ellinger, Jörg ^a   Wittkamp, Volker ^a   Albers, Peter ^b   Perabo, Frank G E ^a   Mueller, Stefan C ^a   von Ruecker, Alexander ^a   Bastian, Patrick J ^c  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b KLINIKUM KASSEL   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

biological markers; cell free system; germ cell and embryonal; neoplasms; testicular neoplasms; testis

Indexed keywords

ALKALINE PHOSPHATASE PLACENTA ISOENZYME; ALPHA FETOPROTEIN; BETA ACTIN; CHORIONIC GONADOTROPIN; DNA; DNA FRAGMENT; LACTATE DEHYDROGENASE;

ADULT; ARTICLE; BLOOD LEVEL; CANCER DIAGNOSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DNA FRAGMENTATION; DNA ISOLATION; GERM CELL TUMOR; HUMAN; MAJOR CLINICAL STUDY; MALE; NON SEMINOMATOUS GERMINOMA; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SEMINOMA;

ADOLESCENT; ADULT; DNA; HUMANS; MALE; MIDDLE AGED; NEOPLASMS, GERM CELL AND EMBRYONAL; TESTICULAR NEOPLASMS; YOUNG ADULT;

EID: 57149117112     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2008.08.118     Document Type: Article

References (20)

1. Jemal A., Siegel R., Ward E., Murray T., Xu J., and Thun M.J. Cancer statistics, 2007. CA Cancer J Clin 57 (2007) 43
2. Huyghe E., Matsuda T., and Thonneau P. Increasing incidence of testicular cancer worldwide: a review. J Urol 170 (2003) 5
3. International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. International Germ Cell Cancer Collaborative Group. J Clin Oncol 15 (1997) 594
4. Trigo J.M., Tabernero J.M., Paz-Ares L., Garcia-Llano J.L., Mora J., Lianes P., et al. Tumor markers at the time of recurrence in patients with germ cell tumors. Cancer 88 (2000) 162
5. Leon S.A., Shapiro B., Sklaroff D.M., and Yaros M.J. Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res 37 (1977) 646
6. Jahr S., Hentze H., Englisch S., Hardt D., Fackelmayer F.O., Hesch R.D., et al. DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res 61 (2001) 1659
7. Ellinger J., Bastian P.J., Haan K.I., Heukamp L.C., Buettner R., Fimmers R., et al. Noncancerous PTGS2 DNA fragments of apoptotic origin in sera of prostate cancer patients qualify as diagnostic and prognostic indicators. Int J Cancer 122 (2008) 138
8. Ellinger J., Bastian P.J., Ellinger N., Perabo F.G., Buettner R., Mueller S.C., et al. Apoptotic DNA fragments in serum of patients with muscle invasive bladder cancer: a prognostic entity. Cancer Lett 264 (2008) 274
9. Chang H.W., Lee S.M., Goodman S.N., Singer G., Cho S.K., Sokoll L.J., et al. Assessment of plasma DNA levels, allelic imbalance, and CA 125 as diagnostic tests for cancer. J Natl Cancer Inst 94 (2002) 1697
10. Bastian P.J., Palapattu G.S., Yegnasubramanian S., Lin X., Rogers C.G., Mangold L.A., et al. Prognostic value of preoperative serum cell-free circulating DNA in men with prostate cancer undergoing radical prostatectomy. Clin Cancer Res 13 (2007) 5361
11. Umetani N., Giuliano A.E., Hiramatsu S.H., Amersi F., Nakagawa T., Martino S., et al. Prediction of breast tumor progression by integrity of free circulating DNA in serum. J Clin Oncol 24 (2006) 4270
12. Umetani N., Kim J., Hiramatsu S., Reber H.A., Hines O.J., Bilchik A.J., et al. Increased integrity of free circulating DNA in sera of patients with colorectal or periampullary cancer: direct quantitative PCR for ALU repeats. Clin Chem 52 (2006) 1062
13. Gautschi O., Bigosch C., Huegli B., Jermann M., Marx A., Chasse E., et al. Circulating deoxyribonucleic acid as prognostic marker in non-small-cell lung cancer patients undergoing chemotherapy. J Clin Oncol 22 (2004) 4157
14. Lo Y.M., Zhang J., Leung T.N., Lau T.K., Chang A.M., and Hjelm N.M. Rapid clearance of fetal DNA from maternal plasma. Am J Hum Genet 64 (1999) 218
15. Lam N.Y., Rainer T.H., Chan L.Y., Joynt G.M., and Lo Y.M. Time course of early and late changes in plasma DNA in trauma patients. Clin Chem 49 (2003) 1286
16. de Kok J.B., Hendriks J.C., van Solinge W.W., Willems H.L., Mensink E.J., and Swinkels D.W. Use of real-time quantitative PCR to compare DNA isolation methods. Clin Chem 44 (1998) 2201
17. Tsui N.B., Ng E.K., and Lo Y.M. Stability of endogenous and added RNA in blood specimens, serum, and plasma. Clin Chem 48 (2002) 1647
18. Umetani N., Hiramatsu S., and Hoon D.S. Higher amount of free circulating DNA in serum than in plasma is not mainly caused by contaminated extraneous DNA during separation. Ann N Y Acad Sci 1075 (2006) 299
19. Mehra N., Penning M., Maas J., van Daal N., Giles R.H., and Voest E.E. Circulating mitochondrial nucleic acids have prognostic value for survival in patients with advanced prostate cancer. Clin Cancer Res 13 (2007) 421
20. Ellinger J., Mueller S.C., Wernert N., von Ruecker A., and Bastian P.J. Mitochondrial DNA in serum of patients with prostate cancer: a predictor of biochemical recurrence following prostatectomy. BJU Int 102 (2008) 628