Real-time imaging of apoptosis induction of human breast cancer cells by the traditional chinese medicinal herb tubeimu

Anticancer Research

Volumn 32, Issue 7, 2012, Pages 2509-2514

  Hu, Mingxin ^a   Zhao, Ming ^b   An, Chao ^a   Yang, Meng ^b,c   Li, Quanwang ^a   Zhang, Yong ^b   Suetsugu, Atsushi ^b,d,e   Tome, Yasunori ^b,d,f   Yano, Shuya ^b,d,g   Fu, Yanling ^a   Hoffman, Robert M ^b,c,d   Hu, Kaiwen ^a  

^a BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b ANTICANCER INC   (United States)

^c AntiCancer Beijing Co Ltd   (China)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f UNIVERSITY OF THE RYUKYUS   (Japan)

^g OKAYAMA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Bolbostemma paniculatum; Breast cancer cells; GFP; Real time imaging; RFP; TCM; Traditional chinese medicine; Tubeimu

Indexed keywords

DICHLOROMETHANE; GELFOAM; GREEN FLUORESCENT PROTEIN; HERBACEOUS AGENT; HISTONE H2B; RED FLUORESCENT PROTEIN; TUBEIMU; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BOLBOSTEMMA; BREAST CANCER; CANCER CELL; CELL CULTURE; CELL ENGINEERING; CHINESE MEDICINE; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; DNA FRAGMENTATION; DRUG EFFICACY; FLUORESCENCE MICROSCOPY; GEL ELECTROPHORESIS; HERBAL MEDICINE; HUMAN; HUMAN TISSUE; MOLECULAR DYNAMICS; MOLECULAR IMAGING; NUCLEAR SHAPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; THREE DIMENSIONAL IMAGING;

APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CUCURBITACEAE; DRUGS, CHINESE HERBAL; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FEMALE; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; MEDICINE, CHINESE TRADITIONAL; MICROSCOPY, FLUORESCENCE; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL;

EID: 84865680519     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Yu TX, Ma RD and Yu LJ: Structure-activity relationship of tubeimosides in anti-inflammatory, antitumor and antitumor-promoting effects. Acta Pharmacol Sin 22(5): 463-468, 2001.
2. Weng XY, Ma RD and Yu LJ: Apoptosis of human nasopharyngeal carcinoma CNE-2Z cells induced by tubeimoside I. Ai Zheng Chinese J Cancer 22(8): 806-811, 2003.
3. Ma RD, Yu LJ, Su WM, Shao HY, Hao MN, He DM and Huang LZ: Induction of cell cycle arrest and apoptosis by tubeimoside I isolated from Bolbostemma paniculatum in HeLa cells. Chinese Clin Pharmacol Therap 9(3): 261-269, 2004.
4. Wang CX, Ma RD and Yu LJ: Effect of tubeimu sapion on invasion of human high metastasis lung cancer cell PGCL3. Chinese Clin Pharmacol Therap 11(1): 39-44, 2006.
5. Wang YS, Deng LH, Zhong HZ, Wang YJ, Jiang XM and Chen J: Natural plant extract tubeimoside I promotes apoptosis-mediated cell death in cultured human hepatoma (HepG2) cells. Biol Pharm Bull 34(6): 831-838, 2011.
6. Li M, Yu JX, Shun D, Qian XS, Hu SX and Ye HJ: Study on apoptosis and differentiation of stomach cancer cell induced by tubeimu. Chinese J Integrated Trad Western Med 22: 201-203, 2002.
7. Yu C, Qui ZY, Tang WX and Li HZ: Apoptosis of SW480 induced by sapion of tubeimu. Chinese Pharmcol Bull 22(7): 880-884, 2006.
8. Li XG, Nan XY and Dang JG: Study on the effect of tubeimu on human renal cancer cell. Chinese J Urol 18(8): 503, 1997.
9. Yamamoto N, Jiang P, Yang M, Xu M, Yamauchi K, Tsuchiya H, Tomita K, Wahl GM, Moossa AR and Hoffman RM: Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression. Cancer Res 64: 4251-4256, 2004. (Pubitemid 38802430)
10. Jiang P, Yamauchi K, Yang M, Tsuji K, Xu M, Maitra A, Bouvet M and Hoffman RM: Tumor cells genetically labeled with GFP in the nucleus and RFP in the cytoplasm for imaging cellular dynamics. Cell Cycle 5: 1198-1201, 2006. (Pubitemid 43845380)
11. Hoffman RM, Yang M: Subcellular imaging in the live mouse. Nature Prot 1: 775-782, 2006.
12. Vescio RA, Redfern CH, Nelson TJ, Ugoretz S, Stern PH and Hoffman RM: In vivo -like drug response of human tumors growing in three-dimensional, gel-supported, primary culture. Proc Natl Acad Sci USA 84: 5029-5033, 1987. (Pubitemid 17095858)
13. Freeman A, Hoffman RM: In vivo-like growth of human tumors in vitro. Proc Natl Acad Sci USA 83: 2694-2698, 1986. (Pubitemid 16026950)
14. Uchugonova A, Duong J, Zhang N, König K and Hoffman RM: The bulge area is the origin of nestin-expressing pluripotent stem cells of the hair follicle. J Cell Biochem 112: 2046-2050, 2011.
15. Hoffman RM: Histocultures and their use. In: Encyclopedia of Life Sciences. John Wiley and Sons, Ltd: Chichester 2010, published online. DOI: 10.1002/9780470015902.a0002573.pub2.