메뉴 건너뛰기




Volumn 14, Issue 4, 2012, Pages 398-405

Antipsychotic agents in the treatment of anorexia nervosa: Neuropsychopharmacologic rationale and evidence from controlled trials

Author keywords

5 HT receptors; AN; Anorexia nervosa; Antipsychotics; Aripiprazole; Behavior therapy; Chlorpromazine; Cognitive behavioral therapy; DA receptors; Delusions; Dopamine; Eating disorders; Genetics; Neurophysiology; Neuropsychopharmacology; Olanzapine; Pimozide; Quetiapine; Risperidone; Serotonin; Sulpiride; Treatment

Indexed keywords

ARIPIPRAZOLE; ATYPICAL ANTIPSYCHOTIC AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; CHLORPROMAZINE; DOPAMINE; OLANZAPINE; PIMOZIDE; PLACEBO; RISPERIDONE; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SULPIRIDE;

EID: 84865659617     PISSN: 15233812     EISSN: 15351645     Source Type: Journal    
DOI: 10.1007/s11920-012-0287-6     Document Type: Article
Times cited : (40)

References (55)
  • 2
    • 34247134544 scopus 로고    scopus 로고
    • Is anorexia nervosa a delusional disorder? An assessment of eating beliefs in anorexia nervosa
    • DOI 10.1097/01.pra.0000265762.79753.88, PII 0013174620070300000002
    • Steinglass JE, Eisen JL, Attia E, et al. Is anorexia nervosa a delusional disorder? An assessment of eating beliefs in anorexia nervosa. J Psychiatr Prac. 2007;13:65-71. (Pubitemid 46588307)
    • (2007) Journal of Psychiatric Practice , vol.13 , Issue.2 , pp. 65-71
    • Steinglass, J.E.1    Eisen, J.L.2    Attia, E.3    Mayer, L.4    Walsh, B.T.5
  • 3
    • 0004235298 scopus 로고
    • American Psychiatric Association. 4th ed. Washington: American Psychiatric Association
    • American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-IV). 4th ed. Washington: American Psychiatric Association; 1994.
    • (1994) Diagnostic and statistical manual of mental disorders (DSM-IV)
  • 4
    • 80053215800 scopus 로고    scopus 로고
    • Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: A systematic review and meta-analysis
    • Maher AR, Maglione M, Bagley S, et al. Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis. JAMA. 2011;306:1359-69.
    • (2011) JAMA , vol.306 , pp. 1359-1369
    • Maher, A.R.1    Maglione, M.2    Bagley, S.3
  • 5
    • 20344391680 scopus 로고    scopus 로고
    • Comorbidity of bipolar and eating disorders: Distinct or related disorders with shared dysregulations?
    • DOI 10.1016/j.jad.2004.11.008, PII S0165032704004367
    • McElroy SL, Kotwal R, Keck Jr. PE, Akiskal HS. Comorbidity of bipolar and eating disorders: distinct or related disorders with shared dysregulations? J Affect Dis. 2005;86:107-27. (Pubitemid 40789945)
    • (2005) Journal of Affective Disorders , vol.86 , Issue.2-3 , pp. 107-127
    • McElroy, S.L.1    Kotwal, R.2    Keck Jr., P.E.3    Akiskal, H.S.4
  • 6
    • 34249982460 scopus 로고    scopus 로고
    • Comorbidity of eating disorders with bipolar disorder and treatment implications
    • DOI 10.1111/j.1399-5618.2006.00401.x
    • McElroy SL, Kotwal R, Keck Jr. PE. Comorbidity of eating disorders with bipolar disorder and treatment implications. Bipolar Dis. 2006;8:686-95. (Pubitemid 44824709)
    • (2006) Bipolar Disorders , vol.8 , Issue.6 , pp. 686-695
    • McElroy, S.L.1    Kotwal, R.2    Keck, P.E.3
  • 7
    • 52149101192 scopus 로고    scopus 로고
    • Prevalence and correlates of eating disorder co-morbidity in patients with bipolar disorder
    • Wildes JE, Marcus MD, Fagiolini A. Prevalence and correlates of eating disorder co-morbidity in patients with bipolar disorder. Psychiatry Res. 2008;161:51-8.
    • (2008) Psychiatry Res , vol.161 , pp. 51-58
    • Wildes, J.E.1    Marcus, M.D.2    Fagiolini, A.3
  • 8
    • 33344473733 scopus 로고    scopus 로고
    • Combined treatment of olanzapine and mirtazapine in anorexia nervosa associated with major depression
    • Wang TS, Chou YH, Shiah IS. Combined treatment of olanzapine and mirtazapine in anorexia nervosa associated with major depression. Prog Neuro-Psychopharm Biol Psychiatry. 2006;30:306-9.
    • (2006) Prog Neuro-Psychopharm Biol Psychiatry , vol.30 , pp. 306-309
    • Wang, T.S.1    Chou, Y.H.2    Shiah, I.S.3
  • 9
    • 15744377084 scopus 로고    scopus 로고
    • Medication response in the treatment of patients with anorexia nervosa
    • Attia E, Mayer L, Killory E. Medication response in the treatment of patients with anorexia nervosa. J Psychiatr Pract. 2001;7:157-62.
    • (2001) J Psychiatr Pract , vol.7 , pp. 157-162
    • Attia, E.1    Mayer, L.2    Killory, E.3
  • 11
    • 84865626374 scopus 로고    scopus 로고
    • Drug therapy for patients with eating disorders
    • Brewerton TD. Drug therapy for patients with eating disorders. Psychiatric Times. 2004;21:59-68.
    • (2004) Psychiatric Times , vol.21 , pp. 59-68
    • Brewerton, T.D.1
  • 12
    • 0028892925 scopus 로고
    • Toward a unified theory of serotonin dysregulation in eating and related disorders
    • Brewerton TD. Toward a unified theory of serotonin dysregulation in eating and related disorders. Psychoneuroendocrinol. 1995;20:561-90.
    • (1995) Psychoneuroendocrinol , vol.20 , pp. 561-590
    • Brewerton, T.D.1
  • 13
    • 84865654110 scopus 로고    scopus 로고
    • Transmitter systems in the eating disorders
    • In: D'haenen H, den Boer JA, Westenberg H, Willner P (ed) New York: Wiley
    • Brewerton TD. Transmitter systems in the eating disorders. In: D'haenen H, den Boer JA, Westenberg H, Willner P (ed) Textbook of biological psychiatry. New York: Wiley; 2002.
    • (2002) Textbook of Biological Psychiatry
    • Brewerton, T.D.1
  • 14
    • 34248383894 scopus 로고    scopus 로고
    • Neurotransmitter dysregulation in anorexia nervosa, bulimia nervosa and binge eating disorder
    • In: Brewerton TD, editor London: Marcel Dekker
    • Brewerton TD, Steiger H. Neurotransmitter dysregulation in anorexia nervosa, bulimia nervosa and binge eating disorder. In: Brewerton TD, editor. Clinical handbook of eating disorders: An integrated approach. London: Marcel Dekker; 2004.
    • (2004) Clinical Handbook of Eating Disorders: An Integrated Approach
    • Brewerton, T.D.1    Steiger, H.2
  • 16
    • 0030753294 scopus 로고    scopus 로고
    • Persistent alterations in behavior and serotonin activity after recovery from anorexia and bulimia nervosa
    • DOI 10.1111/j.1749-6632.1997.tb48204.x
    • Kaye WH. Persistent alterations in behavior and serotonin activity after recovery from anorexia and bulimia nervosa. Ann N Y Acad Sci. 1997;817:162-78. (Pubitemid 27344647)
    • (1997) Annals of the New York Academy of Sciences , vol.817 , pp. 162-178
    • Kaye, W.H.1
  • 17
    • 0025740316 scopus 로고
    • Altered serotonin activity in anorexia nervosa after long-term weight restoration
    • Kaye WH, Gwirtsman HE, George DT, Ebert MH. Altered serotonin activity in anorexia nervosa after long-term weight restoration. Arch Gen Psychiatry. 1991;48:556-62.
    • (1991) Arch Gen Psychiatry , vol.48 , pp. 556-562
    • Kaye, W.H.1    Gwirtsman, H.E.2    George, D.T.3    Ebert, M.H.4
  • 18
    • 0033562964 scopus 로고    scopus 로고
    • New directions in treatment research of anorexia and bulimia nervosa
    • DOI 10.1016/S0006-3223(99)00048-7, PII S0006322399000487
    • Kaye W, Strober M, Stein D, Gendall K. New directions in treatment research of anorexia and bulimia nervosa. Biol Psychiatry. 1999;45:1285-92. (Pubitemid 29292504)
    • (1999) Biological Psychiatry , vol.45 , Issue.10 , pp. 1285-1292
    • Kaye, W.1    Strober, M.2    Stein, D.3    Gendall, K.4
  • 19
    • 41849100057 scopus 로고    scopus 로고
    • Neurobiology of anorexia and bulimia nervosa
    • DOI 10.1016/j.physbeh.2007.11.037, PII S0031938407004635
    • Kaye W. Neurobiology of anorexia and bulimia nervosa. Physiol Behav. 2008;94:121-35. (Pubitemid 351506510)
    • (2008) Physiology and Behavior , vol.94 , Issue.1 , pp. 121-135
    • Kaye, W.1
  • 22
    • 55349083304 scopus 로고    scopus 로고
    • Organic background of restrictive-type anorexia nervosa suggested by increased serotonin 1a receptor binding in right frontotemporal cortex of both lean and recovered patients: [18 f]mppf pet scan study
    • Galusca B, Costes N, Zito NG, et al. Organic background of restrictive-type anorexia nervosa suggested by increased serotonin 1A receptor binding in right frontotemporal cortex of both lean and recovered patients: [18 F]MPPF PET scan study. Biol Psychiatry. 2008;64:1009-13.
    • (2008) Biol Psychiatry , vol.64 , pp. 1009-1013
    • Galusca, B.1    Costes, N.2    Zito, N.G.3
  • 23
    • 0037317622 scopus 로고    scopus 로고
    • Decreased 5-ht2a receptor binding in patients with anorexia nervosa
    • Audenaert K, Van Laere K, Dumont F, et al. Decreased 5-HT2a receptor binding in patients with anorexia nervosa. J Nuclear Med. 2003;44:163-9.
    • (2003) J Nuclear Med , vol.44 , pp. 163-169
    • Audenaert, K.1    Van Laere, K.2    Dumont, F.3
  • 26
    • 58049088941 scopus 로고    scopus 로고
    • Platelet monoamine oxidase activity in under weight and weight-recovered females with anorexia nervosa
    • Ehrlich S, Franke L, Schott R, et al. Platelet monoamine oxidase activity in under weight and weight-recovered females with anorexia nervosa. Pharmacopsychiatry. 2008;41:226-31.
    • (2008) Pharmacopsychiatry , vol.41 , pp. 226-231
    • Ehrlich, S.1    Franke, L.2    Schott, R.3
  • 27
  • 28
    • 32844469622 scopus 로고    scopus 로고
    • The 5-HT2A -1438 A/G and 5-HTTLPR polymorphisms and personality dimensions in adolescent anorexia nervosa: Association study
    • DOI 10.1159/000090701
    • Rybakowski F, Slopien A, Dmitrzak-Weglarz M, et al. The 5-HT2A-1438 A/G and 5-HTTLPR polymorphisms and personality dimensions in adolescent anorexia nervosa: association study. Neuropsychobiology. 2006;53:33-9. (Pubitemid 43254175)
    • (2006) Neuropsychobiology , vol.53 , Issue.1 , pp. 33-39
    • Rybakowski, F.1    Slopien, A.2    Dmitrzak-Weglarz, M.3    Czerski, P.4    Rajewski, A.5    Hauser, J.6
  • 29
    • 77955634427 scopus 로고    scopus 로고
    • Evidence of complex involvement of serotonergic genes with restrictive and binge purge subtypes of anorexia nervosa
    • This recent genetic study showed a substantial and complex inter-relationship between several serotoninergic genes and AN. HTR2A was associated with both AN subtypes, while genes encoding HTR1D and HTR1B were associated with anorexia nervosa, restricting type and the gene encoding HTR2C was associated with anorexia nervosa, binge-purge type. This study will help to guide future genetic research and also gives support for the use of atypical antipsychotics, such as olanzapine
    • Kiezebrink K, Mann ET, Bujac SR, Stubbins MJ, Campbell DA, Blundell JE. Evidence of complex involvement of serotonergic genes with restrictive and binge purge subtypes of anorexia nervosa. World J Biol Psychiatry. 2010;11:824-33. This recent genetic study showed a substantial and complex inter-relationship between several serotoninergic genes and AN. HTR2A was associated with both AN subtypes, while genes encoding HTR1D and HTR1B were associated with anorexia nervosa, restricting type and the gene encoding HTR2C was associated with anorexia nervosa, binge-purge type. This study will help to guide future genetic research and also gives support for the use of atypical antipsychotics, such as olanzapine.
    • (2010) World J Biol Psychiatry , vol.11 , pp. 824-833
    • Kiezebrink, K.1    Mann, E.T.2    Bujac, S.R.3    Stubbins, M.J.4    Campbell, D.A.5    Blundell, J.E.6
  • 31
    • 0037526427 scopus 로고    scopus 로고
    • Association of the 5-HT2c gene with susceptibility and minimum body mass index in anorexia nervosa
    • DOI 10.1097/00001756-200305060-00001
    • Hu X, Giotakis O, Li T, et al. Association of the 5-HT2c gene with susceptibility and minimum body mass index in anorexia nervosa. Neuroreport. 2003;14:781-3. (Pubitemid 36667911)
    • (2003) NeuroReport , vol.14 , Issue.6 , pp. 781-783
    • Hu, X.1    Giotakis, O.2    Li, T.3    Karwautz, A.4    Treasure, J.5    Collier, D.A.6
  • 32
    • 70349560389 scopus 로고    scopus 로고
    • Functional variants of the serotonin receptor type 3a and b gene are associated with eating disorders
    • Hammer C, Kapeller J, Endele M, et al. Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders. Pharmacogenet Genom. 2009;19:790-9.
    • (2009) Pharmacogenet Genom , vol.19 , pp. 790-799
    • Hammer, C.1    Kapeller, J.2    Endele, M.3
  • 33
    • 70449407287 scopus 로고    scopus 로고
    • Polymorphisms in serotonin-related genes in anorexia nervosa. The first study in czech population and metaanalyses with previously performed studies
    • Martaskova D, Slachtova L, Kemlink D, et al. Polymorphisms in serotonin-related genes in anorexia nervosa. The first study in Czech population and metaanalyses with previously performed studies. Folia Biol. 2009;55:192-7.
    • (2009) Folia Biol , vol.55 , pp. 192-197
    • Martaskova, D.1    Slachtova, L.2    Kemlink, D.3
  • 34
    • 33846378438 scopus 로고    scopus 로고
    • Further Evidence of Association of OPRD1 & HTR1D Polymorphisms with Susceptibility to Anorexia Nervosa
    • DOI 10.1016/j.biopsych.2006.04.007, PII S000632230600477X
    • Brown KM, Bujac SR, Mann ET, et al. Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa. Biol Psychiatry. 2007;61:367-73. (Pubitemid 46131428)
    • (2007) Biological Psychiatry , vol.61 , Issue.3 , pp. 367-373
    • Brown, K.M.O.1    Bujac, S.R.2    Mann, E.T.3    Campbell, D.A.4    Stubbins, M.J.5    Blundell, J.E.6
  • 35
    • 27644471945 scopus 로고    scopus 로고
    • Olanzapine reduces physical activity in rats exposed to activity-based anorexia: Possible implications for treatment of anorexia nervosa?
    • DOI 10.1016/j.biopsych.2005.04.008, PII S0006322305004403
    • Hillebrand JJ, van Elburg AA, Kas MJ, van Engeland H, Adan RA. Olanzapine reduces physical activity in rats exposed to activity-based anorexia: possible implications for treatment of anorexia nervosa? Biol Psychiatry. 2005;58:651-7. (Pubitemid 41565580)
    • (2005) Biological Psychiatry , vol.58 , Issue.8 , pp. 651-657
    • Hillebrand, J.J.G.1    Van Elburg, A.A.2    Kas, M.J.H.3    Van Engeland, H.4    Adan, R.A.H.5
  • 40
    • 78349235017 scopus 로고    scopus 로고
    • Epigenetic dysregulation of dopaminergic genes in eating disorders
    • Frieling H, Romer KD, Scholz S, et al. Epigenetic dysregulation of dopaminergic genes in eating disorders. Int J Eat Disord. 2010;43:577-83.
    • (2010) Int J Eat Disord , vol.43 , pp. 577-583
    • Frieling, H.1    Romer, K.D.2    Scholz, S.3
  • 41
    • 80053512593 scopus 로고    scopus 로고
    • A meta-analysis of circulating bdnf concentrations in anorexia nervosa
    • This study suggests that BDNF is not only an important indicator of illness and recovery but may also be a target for drug action in the treatment of AN. It is already known that atypical antipsychotics, especially olanzapine, increase BDNF levels
    • Brandys MK, Kas MJ, van Elburg AA. A meta-analysis of circulating BDNF concentrations in anorexia nervosa. World J Biol Psychiatry. 2011;12:444-54. This study suggests that BDNF is not only an important indicator of illness and recovery but may also be a target for drug action in the treatment of AN. It is already known that atypical antipsychotics, especially olanzapine, increase BDNF levels.
    • (2011) World J Biol Psychiatry , vol.12 , pp. 444-454
    • Brandys, M.K.1    Kas, M.J.2    Van Elburg, A.A.3
  • 42
    • 70149090847 scopus 로고    scopus 로고
    • Serum brain-derived neurotrophic factor and peripheral indicators of the serotonin system in underweight and weight-recovered adolescent girls and women with anorexia nervosa
    • Ehrlich S, Salbach-Andrae H, Eckart S, et al. Serum brain-derived neurotrophic factor and peripheral indicators of the serotonin system in underweight and weight-recovered adolescent girls and women with anorexia nervosa. J Psych Neurosci. 2009;34:323-9.
    • (2009) J Psych Neurosci , vol.34 , pp. 323-329
    • Ehrlich, S.1    Salbach-Andrae, H.2    Eckart, S.3
  • 44
    • 55449100566 scopus 로고    scopus 로고
    • Genetic susceptibility to eating disorders: Associated polymorphisms and pharmacogenetic suggestions
    • Monteleone P, Maj M. Genetic susceptibility to eating disorders: associated polymorphisms and pharmacogenetic suggestions. Pharmacogenomics. 2008;9:1487-520.
    • (2008) Pharmacogenomics , vol.9 , pp. 1487-1520
    • Monteleone, P.1    Maj, M.2
  • 45
    • 1942458526 scopus 로고    scopus 로고
    • Describing an atypical antipsychotic: Receptor binding and its role in pathophysiology
    • Stahl SM. Describing an atypical antipsychotic: Receptor binding and its role in pathophysiology. J Clin Psychiatry. 2003;5 Suppl 3:9-13.
    • (2003) J Clin Psychiatry , vol.5 , Issue.SUPPL. 3 , pp. 9-13
    • Stahl, S.M.1
  • 46
    • 77950826973 scopus 로고    scopus 로고
    • Reduced serum bdnf levels in patients with chronic schizophrenic disorder in relapse, who were treated with typical or atypical antipsychotics
    • Rizos EN, Papadopoulou A, Laskos E, et al. Reduced serum BDNF levels in patients with chronic schizophrenic disorder in relapse, who were treated with typical or atypical antipsychotics. World J Biol Psychiatry. 2010;11:251-5.
    • (2010) World J Biol Psychiatry , vol.11 , pp. 251-255
    • Rizos, E.N.1    Papadopoulou, A.2    Laskos, E.3
  • 48
    • 52249097471 scopus 로고    scopus 로고
    • Olanzapine in the treatment of low body weight and obsessive thinking in women with anorexia nervosa: A randomized, double-blind, placebocontrolled trial
    • This is a very important randomized, placebo-controlled study that demonstrated olanzapine's ability to promote faster weight gain and alleviate obsessive symptoms in adult patients with AN who were receiving concurrent day treatment
    • Bissada H, Tasca GA, Barber AM, Bradwejn J. Olanzapine in the treatment of low body weight and obsessive thinking in women with anorexia nervosa: a randomized, double-blind, placebocontrolled trial. Am J Psychiatry. 2008;165:1281-8. This is a very important randomized, placebo-controlled study that demonstrated olanzapine's ability to promote faster weight gain and alleviate obsessive symptoms in adult patients with AN who were receiving concurrent day treatment.
    • (2008) Am J Psychiatry , vol.165 , pp. 1281-1288
    • Bissada, H.1    Tasca, G.A.2    Barber, A.M.3    Bradwejn, J.4
  • 49
    • 80054948275 scopus 로고    scopus 로고
    • Olanzapine versus placebo for out-patients with anorexia nervosa
    • This is a recent breakthrough study which showed that olanzapine significantly facilitates weight recovery in adult outpatients with AN in comparison to placebo. This was despite the absence of any adjunctive psychotherapy or behavior therapy during the trial
    • Attia E, Kaplan AS, Walsh BT, et al. Olanzapine versus placebo for out-patients with anorexia nervosa. Psychol Med. 2011;41:2177-82. This is a recent breakthrough study which showed that olanzapine significantly facilitates weight recovery in adult outpatients with AN in comparison to placebo. This was despite the absence of any adjunctive psychotherapy or behavior therapy during the trial.
    • (2011) Psychol Med , vol.41 , pp. 2177-2182
    • Attia, E.1    Kaplan, A.S.2    Walsh, B.T.3
  • 52
    • 0020438204 scopus 로고
    • Pimozide combined with behavior therapy in the short-term treatment of anorexia nervosa. A double-blind placebo-controlled cross-over study
    • Vandereycken W, Pierloot R. Pimozide combined with behavior therapy in the short-term treatment of anorexia nervosa. A doubleblind placebo-controlled cross-over study. Acta Psychiatr Scand. 1982;66:445-50. (Pubitemid 13242401)
    • (1982) Acta Psychiatrica Scandinavica , vol.66 , Issue.6 , pp. 445-450
    • Vandereycken, W.1    Pierloot, R.2
  • 53
    • 0021321297 scopus 로고
    • Neuroleptics in the short-term treatment of anorexia nervosa: A double-blind placebo-controlled study with sulpiride
    • Vandereycken W. Neuroleptics in the short-term treatment of anorexia nervosa. A double-blind placebo-controlled study with sulpiride. Br J Psychiatry. 1984;144:288-92. (Pubitemid 14159403)
    • (1984) British Journal of Psychiatry , vol.144 , Issue.3 , pp. 288-292
    • Vandereycken, W.1
  • 54
    • 84855409067 scopus 로고    scopus 로고
    • A double-blind, placebocontrolled study of risperidone for the treatment of adolescents and young adults with anorexia nervosa: A pilot study
    • This is the only randomized, placebo-controlled study that has examined the role of risperidone in the treatment of ANin this case, adolescent inpatients being treated in a specialized eating disorder service. Although there was no difference in weight gain, those receiving risperidone demonstrated significant improvements in interpersonal distrust compared with placebo
    • Hagman J, Gralla J, Sigel E, et al. A double-blind, placebocontrolled study of risperidone for the treatment of adolescents and young adults with anorexia nervosa: a pilot study. J Am Acad Child Adol Psych. 2011;50:915-24. This is the only randomized, placebo-controlled study that has examined the role of risperidone in the treatment of AN -in this case, adolescent inpatients being treated in a specialized eating disorder service. Although there was no difference in weight gain, those receiving risperidone demonstrated significant improvements in interpersonal distrust compared with placebo.
    • (2011) J Am Acad Child Adol Psych , vol.50 , pp. 915-924
    • Hagman, J.1    Gralla, J.2    Sigel, E.3
  • 55
    • 79958864906 scopus 로고    scopus 로고
    • A placebo-controlled pilot study of adjunctive olanzapine for adolescents with anorexia nervosa
    • This recent randomized, placebo-controlled study examined the role of olanzapine in a group of adolescents being treated in a specialty eating disorder service. There was no statistically significant benefit of olanzapine for weight or psychological symptoms. Again, we see that olanzapine seems to primarily benefit individuals who are not receiving concurrent intensive treatment
    • Kafantaris V, Leigh E, Hertz S, et al. A placebo-controlled pilot study of adjunctive olanzapine for adolescents with anorexia nervosa. J Child Adol Psychopharmacol. 2011;21:207-12. This recent randomized, placebo-controlled study examined the role of olanzapine in a group of adolescents being treated in a specialty eating disorder service. There was no statistically significant benefit of olanzapine for weight or psychological symptoms. Again, we see that olanzapine seems to primarily benefit individuals who are not receiving concurrent intensive treatment.
    • (2011) J Child Adol Psychopharmacol , vol.21 , pp. 207-212
    • Kafantaris, V.1    Leigh, E.2    Hertz, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.