Exposure to ionizing radiation causes long-term increase in serum estradiol and activation of PI3K-Akt signaling pathway in mouse mammary gland

International Journal of Radiation Oncology Biology Physics

Volumn 84, Issue 2, 2012, Pages 500-507

  Suman, Shubhankar ^a   Johnson, Michael D ^b   Fornace Jr , Albert J ^a,b   Datta, Kamal ^a  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

Author keywords

Estradiol; Estrogen; Estrogen metabolite; Estrogen receptor ; Radiation

Indexed keywords

BREAST CANCER; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; FRACTIONATED RADIOTHERAPY; IMMUNOHISTOCHEMISTRY; IMMUNOSTAINING; IRRADIATED ANIMALS; IRRADIATED SAMPLES; MAMMARY GLAND; MAMMARY TISSUE; MOLECULAR EVENTS; MOLECULAR PATHWAYS; MULTISTAGE PROCESS; NUCLEAR ACCUMULATION; PATHOPHYSIOLOGIC; RADIATION EXPOSURE; RADIATION-INDUCED; RISK FACTORS; SIGNALING PATHWAYS; URINE SAMPLE; WESTERN BLOTS;

BODY FLUIDS; DISEASES; HEAT RADIATION; IONIZING RADIATION; MAMMALS; METABOLITES; RADIATION SHIELDING; TISSUE;

RADIOTHERAPY;

CYCLIN D1; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; KI 67 ANTIGEN; MAMMALIAN TARGET OF RAPAMYCIN; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVATION; ESTRADIOL BLOOD LEVEL; FEMALE; IMMUNOHISTOCHEMISTRY; IONIZING RADIATION; MAMMARY GLAND; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; CELL PROLIFERATION; CYCLIN D1; DOSE FRACTIONATION; ENZYME ACTIVATION; ESTRADIOL; ESTROGENS; FEMALE; KI-67 ANTIGEN; MAMMARY GLANDS, ANIMAL; MICE; MICE, INBRED C57BL; NEOPLASMS, RADIATION-INDUCED; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION; STEROID 16-ALPHA-HYDROXYLASE; WHOLE-BODY IRRADIATION;

EID: 84865658953     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.12.033     Document Type: Article

References (20)

1. C.M. Ronckers, C.A. Erdmann, and C.E. Land Radiation and breast cancer: A review of current evidence Breast Cancer Res 7 2005 21 32
2. J.D.J. Boice, E.B. Harvey, and M. Blettner Cancer in the contralateral breast after radiotherapy for breast cancer N Engl J Med 326 1992 781 785
3. D.J. Brenner, R. Doll, and D.T. Goodhead Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know Proc Natl Acad Sci U S A 100 2003 13761 13766
4. H. Ma, C.K. Hill, and L. Bernstein Low-dose medical radiation exposure and breast cancer risk in women under age 50 years overall and by estrogen and progesterone receptor status: Results from a case-control and a case-case comparison Breast Cancer Res Treat 109 2008 77 90
5. A. Segaloff, and W.S. Maxfield The synergism between radiation and estrogen in the production of mammary cancer in the rat Cancer Res 31 1971 166 168
6. G. Ursin, S. London, and F.Z. Stanczyk A pilot study of urinary estrogen metabolites (16alpha-OHE1 and 2-OHE1) in postmenopausal women with and without breast cancer Environ Health Perspect 105 Suppl 3 1997 601 605
7. A. Im, V.G. Vogel, and G. Ahrendt Urinary estrogen metabolites in women at high risk for breast cancer Carcinogenesis 30 2009 1532 1535
8. A.A. Kazi, K.H. Molitoris, and R.D. Koos Estrogen rapidly activates the PI3K/AKT pathway and hypoxia-inducible factor 1 and induces vascular endothelial growth factor A expression in luminal epithelial cells of the rat uterus Biol Reprod 81 2009 378 387
9. S. Bose, S. Chandran, and J.M. Mirocha The Akt pathway in human breast cancer: A tissue-array-based analysis Mod Pathol 19 2006 238 245
10. J.B. Tyburski, A.D. Patterson, and K.W. Krausz Radiation metabolomics. 1. Identification of minimally invasive urine biomarkers for gamma-radiation exposure in mice Radiat Res 170 2008 1 14
11. F.A.J. Mettler, M. Bhargavan, and K. Faulkner Radiologic and nuclear medicine studies in the United States and worldwide: Frequency, radiation dose, and comparison with other radiation sources - 1950-2007 Radiology 253 2009 520 531
12. E.J. Grant, K. Neriishi, and J. Cologne Associations of ionizing radiation and breast cancer-related serum hormone and growth factor levels in cancer-free female A-bomb survivors Radiat Res 176 2011 678 687
13. M. Kabuto, S. Akiba, and R.G. Stevens A prospective study of estradiol and breast cancer in Japanese women Cancer Epidemiol Biomarkers Prev 9 2000 575 579
14. L. Zhang, M.C. Fishman, and P.L. Huang Estrogen mediates the protective effects of pregnancy and chorionic gonadotropin in a mouse model of vascular injury Arterioscler Thromb Vasc Biol 19 1999 2059 2065
15. V. Cheriyath, M.A. Kuhns, and B.S. Jacobs G1P3, an interferon- and estrogen-induced survival protein contributes to hyperplasia, tamoxifen resistance and poor outcomes in breast cancer Oncogene 2011 In press
16. J.N. Lai, C.T. Wu, and P.C. Chen Increased risk for invasive breast cancer associated with hormonal therapy: A nation-wide random sample of 65,723 women followed from 1997 to 2008 PLoS ONE 6 2011 e25183
17. T. Imaoka, M. Nishimura, and D. Iizuka Pre- and postpubertal irradiation induces mammary cancers with distinct expression of hormone receptors, ErbB ligands, and developmental genes in rats Mol Carcinog 50 2011 539 552
18. D.Z. Liao, C.G. Pantazis, and X. Hou Promotion of estrogen-induced mammary gland carcinogenesis by androgen in the male Noble rat: Probable mediation by steroid receptors Carcinogenesis 19 1998 2173 2180
19. Y. Miyoshi, Y. Tanji, and T. Taguchi Association of serum estrone levels with estrogen receptor-positive breast cancer risk in postmenopausal Japanese women Clin Cancer Res 9 2003 2229 2233
20. L. Bjornstrom, and M. Sjoberg Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes Mol Endocrinol 19 2005 833 842