Species differences in toxicokinetic parameters of glycidol after a single dose of glycidol or glycidol linoleate in rats and monkeys

Journal of Toxicological Sciences

Volumn 37, Issue 4, 2012, Pages 691-698

  Wakabayashi, Ken ichi ^a   Kurata, Yoshimasa ^b   Harada, Tomoo ^b   Tamaki, Yasushi ^a   Nishiyama, Naohiro ^a   Kasamatsu, Toshio ^a  

^a KAO CORPORATION   (Japan)

^b LSI MEDIENCE CORPORATION   (Japan)

Author keywords

DAG oil; Edible oil; Glycidol; Glycidol fatty acid ester; Toxicokinetics

Indexed keywords

FATTY ACID ESTER; GLYCIDOL; GLYCIDOL LINOLEATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG MEGADOSE; LIMIT OF QUANTITATION; LOW DRUG DOSE; MALE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; RAT; SINGLE DRUG DOSE; SPECIES DIFFERENCE; TOXICOKINETICS;

ANIMALIA; MACACA FASCICULARIS; PRIMATES; RATTUS; RODENTIA;

EID: 84865647675     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.37.691     Document Type: Article

References (23)

1. Boogaard, P.J. and Bond, J.A. (1996): The role of hydrolysis in the detoxification of 1,2:3,4-diepoxybutane by human, rat, and mouse liver and lung in vitro. Toxicol. Appl. Pharmacol., 141, 617-627.
2. Boogaard, P.J., Sumner, S.C. and Bond, J.A. (1996): Glutathione conjugation of 1,2:3,4- diepoxybutane in human liver and rat and mouse liver and lung in vitro. Toxicol. Appl. Pharmacol., 136, 307-316.
3. Boogaard, P.J., van Elburg, P.A., de Kloe, K.P., Watson, W.P. and van Sittert, N.J. (1999): Metabolic inactivation of 2-oxiranylmethyl 2-ethyl-2,5-dimethylhexanoate (C10GE) in skin, lung and liver of human, rat and mouse. Xenobiotica, 29, 987-1006.
4. Csanády, G.A., Guengerich, F.P. and Bond, J.A. (1992): Comparison of the biotransformation of 1,3-butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice. Carcinogenesis, 13, 1143-1153.
5. DeNigris, S.J., Hamosh, M., Kasbekar, D.K., Lee, T.C. and Hamosh, P. (1988): Lingual and gastric lipases: species differences in the origin of prepancreatic digestive lipases and in the localization of gastric lipase. Biochim. Biophys. Acta, 959, 38-45.
6. Federal Institute for Risk Assessment (2009): Initial evaluation of the assessment of levels of glycidol fatty acid esters detected in refined vegetable fats. BfR Opinion No. 007/2009, 10 March 2009 http://www.bfr.bund.de/cm/245/initial_evaluation_of_the_assessment_of_levels_of_glycidol_fatty_acid_esters.pdf
7. Gargas, M.L., Kirman, C.R., Sweeney, L.M. and Tardiff, R.G. (2009): Acrylamide: Consideration of species differences and nonlinear processes in estimating risk and safety for human ingestion. Food Chem. Toxicol., 47, 760-768.
8. Habermeyer, M., Guth, S. and Eisenbrand, G. (2011): Identification of gaps in knowledge concerning toxicology of 3-MCPD and glycidol esters. Eur. J. Lipid Sci., 113, 314-318.
9. Honda, H., Onishi, M., Fujii, K., Ikeda, N., Yamaguchi, T., Fujimori, T., Nishiyama, N. and Kasamatsu, T. (2011): Measurement of glycidol hemoglobin adducts in humans who ingest edible oil containing small amounts of glycidol fatty acid esters. Food Chem. Toxicol., 49, 2536-2540.
10. IARC (1976a): Glycidyl oleate. Cadmium, Nickel, Some Epoxides, Miscellaneous Industrial Chemicals and General Considerations on Volatile Anaesthetics. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans, vol. 11. Lyon, France: International Agency for Research on Cancer. pp.183-186.
11. IARC (1976b): Glycidyl stearate. Cadmium, Nickel, Some Epoxides, Miscellaneous Industrial Chemicals and General Considerations on Volatile Anaesthetics. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans, vol. 11. Lyon, France: International Agency for Research on Cancer. pp. 187-190.
12. IARC (1987): Glycidyl oleate, Glycidyl stearate. IARC Mono-graphs on the Evaluation of Carcinogenic Risk of Chemicals to Humans Supplement 7, Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42. Lyon, France: International Agency for Research on Cancer. pp.64.
13. IARC (2000): Glycidol. In Some Industrial Chemicals. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans, vol. 77. Lyon, France: International Agency for Research on Cancer. pp.469-486.
14. International Conference on Harmonisation (1994): Note for Guidance on Toxicokinetics: The Assessment of Systemic Exposure in Toxicity Studies. http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Safety/S3A/Step4/S3A_Guideline.pdf
15. Jones, A.R. (1975): The metabolism of 3-chloro,- 3-bromo- and 3-iodoprpan-1,2-diol in rats and mice. Xenobiotica, 5, 155-165.
16. Kararli, T.T. (1995): Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals. Biopharm. Drug Dispos., 16, 351-380.
17. Kedderis, G.L. and Batra, R. (1993): Species differences in the hydrolysis of 2-cyanoethylene oxide, the epoxide metabolite of acrylonitrile. Carcinogenesis, 14, 685-689.
18. Kedderis, G.L., Batra, R. and Turner, M.J.Jr. (1995): Conjugation of acrylonitrile and 2-cyanoethylene oxide with hepatic glutathione. Toxicol. Appl. Pharmacol., 135, 9-17.
19. Masukawa, Y., Shiro, H., Nakamura, S., Kondo, N., Jin, N., Suzuki, N., Ooi, N. and Kudo, N. (2010): A new analytical method for the quantification of glycidol fatty acid esters in edible oils. J. Oleo Sci., 59, 81-88.
20. Mendrala, A.L., Langvardt, P.W., Nitschke, K.D., Quast, J.F. and Nolan, R.J. (1993): In vitro kinetics of styrene and styrene oxide metabolism in rat, mouse, and human. Arch. Toxicol., 67, 18-27.
21. National Toxicology Program (1990): NTP Toxicology and Carcinogenesis Studies of Glycidol (CAS No. 556-52-5) In F344/N Rats and B6C3F1 Mice (Gavage Studies). Natl. Toxicol. Program Tech. Rep. Ser., 374, 1-229.
22. Nomeir, A.A., Silveira, D.M., Ferrala, N.F., Markham, P.M., McComish, M.F., Ghanayem, B.I. and Chadwick, M. (1995): Comparative disposition of 2,3-epoxy-1-propanol (glycidol) in rats following oral and intravenous administration. J. Toxicol. Environ. Health, 44, 203-217.
23. Patel, J.M., Wood, J.C. and Leibman, K.C. (1980): The biotransformation of allyl alcohol and acrolein in rat liver and lung preparations. Drug Metab. Dispos., 8, 305-308.