Evaluation of cytotoxicity for novel composite embolic microspheres: Material optimization by response surface methodology

Materials Letters

Volumn 86, Issue , 2012, Pages 13-17

  Kehoe, S ^a   Kilcup, N ^a   Boyd, D ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Composites; Design of experiments; Embolics; Glass; Microspheres; Response surface methodology

Indexed keywords

2-FACTORS; 5-LEVEL; COMPOSITE MICROSPHERES; D-OPTIMAL; EMBOLICS; EMBOLIZATION; INCUBATION PERIODS; MATERIAL OPTIMIZATION; MAXIMUM LOADING; RESPONSE SURFACE METHODOLOGY; TARGET CELLS; THERMALLY INDUCED PHASE SEPARATION;

COMPOSITE MATERIALS; DESIGN OF EXPERIMENTS; GLASS; OPTIMIZATION; PHASE SEPARATION; SURFACE PROPERTIES;

MICROSPHERES;

EID: 84865639321     PISSN: 0167577X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.matlet.2012.06.087     Document Type: Article

References (20)

1. V. Verret, S.H. Ghegediban, M. Wassef, J.P. Pelage, J. Golzarian, and A. Laurent The arterial distribution of embozene and embosphere microspheres in sheep kidney and uterus embolization models J Vasc Interventional Radiol 22 2011 220 228
2. V. Verret, C. Bevilacqua, I. Schwartz-Cornil, J.P. Pelage, M. Wassef, and J. Namur IL6 and TNF expression in vessels and surrounding tissues after embolization with ibuprofen-loaded beads confirms diffusion of ibuprofen Eur J Pharm Sci 42 2011 489 495
3. K. Saralidze, C.S.J. van Hooy-Corstjens, L.H. Koole, and M.L.W. Knetsch New acrylic microspheres for arterial embolization: combining radiopacity for precise localization with immobilized thrombin to trigger local blood coagulation Biomaterials 28 2007 2457 2464
4. M. Kubo, N. Kuwayama, Y. Hirashima, A. Takaku, T. Ogawa, and S. Endo Hydroxyapatite ceramics as a particulate embolic material: report of the physical properties of the hydroxyapatite particles and the animal study Am J Neuroradiol 24 2003 1540 1544
5. J.B. Spies, S. Allison, P. Flick, M. Cramp, J. Bruno, and R.C. Jha Spherical polyvinyl alcohol versus tris-acryl gelatin microspheres for uterine artery embolization for leiomyomas: results of a limited randomized comparative study J Vasc Interventional Radiol 16 2005 1431 1437
6. S. Kehoe, R.J. Abraham, E. Tonkopi, and D. Boyd Novel radiopaque embolic agent for uterine fibroid embolization: determination of radiopacity and biological evaluation; cytocompatibility, intracutaneous reactivity and local effects after implantation J Vasc Interventional Radiol 23 Issue 3 2012 Supplement:S33
7. Kehoe S, Langman M, Zwanziger UW, Abraham B, Boyd D. Composition- structure-property (density and cytocompatibility) relationships for experimental embolic particulates. J Biomater Appl, 10.1177/0885328212455834, in press.
8. Kehoe S, Tremblay ML, Coughlan A, Rainey JK, Towler MR, Abraham RJ, et al. Early material and host responses for novel embolic particles. Mater Sci: Mater Med, submitted.
9. A. Laurent Microspheres and nonspherical particles for embolization Tech Vasc Interventional Radiol 10 2007 248 256
10. J.J. Blaker, J.C. Knowles, and R.M. Day Novel fabrication techniques to produce microspheres by thermally induced phase separation for tissue engineering and drug delivery Acta Biomater 4 2008 264 272
11. K.L. Low, S.H. Tan, S.H.S. Zein, D.S. McPhail, and A.R. Boccaccini Optimization of the mechanical properties of calcium phosphate/multi-walled carbon nanotubes/bovine serum albumin composites using response surface methodology Mater Des 32 2011 3312 3319
12. S. Kehoe, X.F. Zhang, and D. Boyd Composition-property relationships for an experimental composite nerve guidance conduit: evaluating cytotoxicity and initial tensile strength Mater Sci: Mater Med 2011
13. P. Whitcomb, and M.D.O.E. Anderson Simplified: practical tools for effective experimentation 2000 Productivity Inc. New York
14. ISO10993-5. Biological evaluation of medical devicespart 5: tests for in vitro cytotoxicity. 2009.
15. O. Tsigkou, J.R. Jones, J.M. Polak, and M.M. Stevens Differentiation of fetal osteoblasts and formation of mineralized bone nodules by 45S5 Bioglass (R) conditioned medium in the absence of osteogenic supplements Biomaterials 30 2009 3542 3550
16. B. Lee, B. West, R. McLemore, C. Pauken, and B. Vernon in-situ injectable physically and chemically gelling N.I.P.A.am-based copolymer system for embolization Biomacromolecules 7 2006 2059 2064
17. SIR Embolization Workshop. Society of interventional radiology annual meeting. San Franscisco 2012.
18. H.J. Sung, C. Meredith, C. Johnson, and Z.S. Galis The effect of scaffold degradation rate on three-dimensional cell growth and angiogenesis Biomaterials 25 2004 5735 5742
19. S. Murphy, A.W. Wren, M.R. Towler, and D. Boyd The effect of ionic dissolution products of CaSrNaZnSi bioactive glass on in vitro cytocompatibility J Mater Sci Mater Med 21 2010 2827 2834
20. I. Foster Cancer: a cell cycle defect Radiography 14 2008 144 149