The time-dependant post-mortem redistribution of antipsychotic drugs

Forensic Science International

Volumn 222, Issue 1-3, 2012, Pages 223-227

  Saar, Eva ^a   Beyer, Jochen ^a,b   Gerostamoulos, Dimitri ^a,b   Drummer, Olaf H ^a,b  

^a MONASH UNIVERSITY   (Australia)

^b VICTORIAN INSTITUTE OF FORENSIC MEDICINE   (Australia)

Author keywords

Antipsychotic drugs; LC MS MS; Post mortem redistribution

Indexed keywords

AMISULPRIDE; CHLORPROMAZINE; CLOZAPINE; HALOPERIDOL; NEUROLEPTIC AGENT; OLANZAPINE; PROMETHAZINE; QUETIAPINE; RISPERIDONE; ZUCLOPENTHIXOL;

ARTICLE; AUTOPSY; BLOOD ANALYSIS; BLOOD SAMPLING; CADAVER; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; FORENSIC TOXICOLOGY; HUMAN; POSTMORTEM DRUG REDISTRIBUTION; PRIORITY JOURNAL; TIME; TOXICOKINETICS;

EID: 84865620480     PISSN: 03790738     EISSN: 18726283     Source Type: Journal    
DOI: 10.1016/j.forsciint.2012.05.028     Document Type: Article

References (29)

1. Drummer O., Odell M. The Forensic Pharmacology of Drugs of Abuse 2001.
2. Prouty R.W., Anderson W.H. The forensic science implications of site and temporal influences on postmortem blood-drug concentrations. J. Forensic Sci. 1990, 2:243-270.
3. Jones G.R., Pounder D.J. Site dependence of drug concentrations in postmortem blood - a case study. J. Anal. Toxicol. 1987, 5:186-190.
4. Pounder D.J. The nightmare of postmortem drug changes. Leg. Med. 1993, 163-191.
5. Pounder D.J., Jones G.R. Post-mortem drug redistribution - a toxicological nightmare. Forensic Sci. Int. 1990, 3:253-263.
6. Leikin J.B., Watson W.A. Post-mortem toxicology: what the dead can and cannot tell us. J. Toxicol. Clin. Toxicol. 2003, 1:47-56.
7. Hilberg T., et al. The extent of postmortem drug redistribution in a rat model. J. Forensic Sci. 1999, 5:956-962.
8. Yarema M.C., Becker C.E. Key concepts in postmortem drug redistribution. Clin. Toxicol. (Phila) 2005, 4:235-241.
9. Flanagan R.J., Amin A., Seinen W. Effect of post-mortem changes on peripheral and central whole blood and tissue clozapine and norclozapine concentrations in the domestic pig (Sus scrofa). Forensic Sci. Int. 2003, 1:9-17.
10. Castaing N., et al. Postmortem redistribution of two antipsychotic drugs, haloperidol and thioridazine, in the rat. J. Anal. Toxicol. 2006, 7:419-425.
11. Aravagiri M., Teper Y., Marder S.R. Pharmacokinetics and tissue distribution of olanzapine in rats. Biopharm. Drug Dispos. 1999, 8:369-377.
12. Jenkins A.J., Sarconi K.M., Raaf H.N. Determination of olanzapine in a postmortem case. J. Anal. Toxicol. 1998, 7:605-609.
13. Horak E.L., Jenkins A.J. Postmortem tissue distribution of olanzapine and citalopram in a drug intoxication. J. Forensic Sci. 2005, 3:679-681.
14. Hopenwasser J., et al. Postmortem distribution of the novel antipsychotic drug quetiapine. J. Anal. Toxicol. 2004, 4:264-267.
15. Cooper T.B., Bost R., Sunshine I. Postmortem blood and tissue levels of loxapine and its metabolites. J. Anal. Toxicol. 1981, 2:99-100.
16. Meeker J.E., et al. Clozapine tissue concentrations following an apparent suicidal overdose of Clozaril. J. Anal. Toxicol. 1992, 1:54-56.
17. Merrick T.C., Felo J.A., Jenkins A.J. Tissue distribution of olanzapine in a postmortem case. Am. J. Forensic Med. Pathol. 2001, 3:270-274.
18. Anderson D.T., Fritz K.L. Quetiapine (Seroquel) concentrations in seven postmortem cases. J. Anal. Toxicol. 2000, 4:300-304.
19. Rodda K.E., Drummer O.H. The redistribution of selected psychiatric drugs in post-mortem cases. Forensic Sci. Int. 2006, 2-3:235-239.
20. Saar E., et al. Identification and quantification of 30 antipsychotics in blood using LC-MS/MS. J. Mass Spectrom. 2010, 8:915-925.
21. Nyberg S., Dahl M.L., Halldin C. A PET study of D2 and 5-HT2 receptor occupancy induced by risperidone in poor metabolizers of debrisoquin and risperidone. Psychopharmacology (Berl.) 1995, 3:345-348.
22. Aravagiri M., et al. Intra- and interindividual variations in steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone in schizophrenic patients treated chronically with various doses of risperidone. Ther. Drug Monit. 2003, 6:657-664.
23. Mannens G., et al. Plasma protein binding of risperidone and its distribution in blood. Psychopharmacology (Berl.) 1994, 4:566-572.
24. Dalpe-Scott M. A comparison of drug concentrations in postmortem cardiac and peripheral blood in 320 cases. Can. Soc. Forensic Sci. 1995, 2:113-121.
25. Jusic N., Lader M. Post-mortem antipsychotic drug concentrations and unexplained deaths. Br. J. Psychiatry 1994, 6:787-791.
26. Vance C., McIntyre I.M. Postmortem tissue concentrations of olanzapine. J. Anal. Toxicol. 2009, 1:15-26.
27. Parker D.R., McIntyre I.M. Case studies of postmortem quetiapine: therapeutic or toxic concentrations?. J. Anal. Toxicol. 2005, 5:407-412.
28. Saar E., et al. Comparison of extraction efficiencies and LC-MS-MS matrix effects using LLE and SPE methods for 19 antipsychotics in human blood. Anal. Bioanal. Chem. 2009, 2:727-734.
29. Baselt R.C. Disposition of Toxic Drugs and Chemicals in Man 2008, 8 ed.