Clostridium difficile prevalence rates in a large healthcare system stratified according to patient population, age, gender, and specimen consistency

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 31, Issue 7, 2012, Pages 1551-1559

  Boone, J H ^a   Goodykoontz, M ^a   Rhodes, S J ^a   Price, K ^a   Smith, J ^a   Gearhart, K N ^a   Carman, R J ^a   Kerkering, T M ^b   Wilkins, T D ^a   Lyerly, D M ^a  

^a TECHLAB INC   (United States)

^b VIRGINIA TECH CARILION SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; MOXIFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; QUINOLONE DERIVATIVE;

ADULT; AGE; ANALYTIC METHOD; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM CULTURE; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATION; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; FECES ANALYSIS; FEMALE; HEALTH CARE SYSTEM; HOSPITAL PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MINIMUM INHIBITORY CONCENTRATION; NURSING HOME; OUTPATIENT; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; RIBOTYPING; SEX DIFFERENCE; TOXIN ANALYSIS; ADOLESCENT; AGED; CHILD; CLASSIFICATION; CLOSTRIDIUM INFECTION; CROSS INFECTION; DRUG EFFECT; FECES; GENETICS; HEALTH CARE FACILITY; ISOLATION AND PURIFICATION; MICROBIOLOGY; MIDDLE AGED; RISK FACTOR;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CHILD; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; CROSS INFECTION; DRUG RESISTANCE, BACTERIAL; FECES; FEMALE; FLUOROQUINOLONES; HEALTH FACILITIES; HUMANS; MALE; MIDDLE AGED; PREVALENCE; RIBOTYPING; RISK FACTORS; SEX FACTORS; YOUNG ADULT;

EID: 84865592772     PISSN: 09349723     EISSN: 14354373     Source Type: Journal    
DOI: 10.1007/s10096-011-1477-6     Document Type: Article

References (34)

1. Bartlett JG (1995) Antibiotic-associated diarrhea. In: Blaser MJ, Smith PD, Ravdin JI, Greenberg HB, Guerrant RL (eds) Infections of the gastrointestinal tract. Raven Press, Ltd., New York
2. Surawicz CM, McFarland LV (1999) Pseudomembranous colitis: Causes and cures. Digestion 60:91-100
3. Bartlett JG (2007) Clostridium difficile: Old and new observations. J Clin Gastroenterol 41(Suppl 1):S24-S29
4. Kyne L, Hamel MB, Polavaram R, Kelly CP (2002) Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile. Clin Infect Dis 34:346-353
5. Hull MW, Beck PL (2004) Clostridium difficile-associated colitis. Can Fam Physician 50:1536-1545
6. Otten AM, Reid-Smith RJ, Fazil A, Weese JS (2010) Disease transmission model for community-associated Clostridium difficile infection. Epidemiol Infect 138(6):907-914
7. Muto CA (2007) Asymptomatic Clostridium difficile colonization: Is this the tip of another iceberg? Clin Infect Dis 45:999-1000
8. Riggs MM, Sethi AK, Zabarsky TF, Eckstein EC, Jump RL, Donskey CJ (2007) Asymptomatic carriers are a potential source for transmission of epidemic and nonepidemic Clostridium difficile strains among long-term care facility residents. Clin Infect Dis 45:992-998
9. Loo VG, Poirier L, Miller MA, Oughton M, Libman MD, Michaud S et al (2005) A predominantly clonal multiinstitutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 353:2442-2449
10. McDonald LC, Killgore GE, Thompson A, Owens RC Jr, Kazakova SV, Sambol SP et al (2005) An epidemic, toxin genevariant strain of Clostridium difficile. N Engl J Med 353:2433-2441
11. McEllistrem MC, Carman RJ, Gerding DN, Genheimer CW, Zheng L (2005) A hospital outbreak of Clostridium difficile disease associated with isolates carrying binary toxin genes. Clin Infect Dis 40:265-272
12. Pépin J, Valiquette L, Cossette B (2005) Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec. CMAJ 173 (9):1037-1042. doi:10.1503/cmaj.050978
13. Hubert B, Loo VG, Bourgault A-M, Poirier L, Dascal A, Fortin E et al (2007) A portrait of the geographic dissemination of the Clostridium difficile North American pulsed-field type 1 strain and the epidemiology of C. difficile-associated disease in Québec. Clin Infect Dis 44(2):238-244
14. O'Connor JR, Johnson S, Gerding DN (2009) Clostridium difficile infection caused by the epidemic BI/NAP1/027 strain. Gastroenterology 136:1913-1924
15. Carman RJ, Genheimer CW, Rafii F, Park M, Hiltonsmith MF, Lyerly DM (2009) Diversity of moxifloxacin resistance during a nosocomial outbreak of a predominantly ribotype ARU 027 Clostridium difficile diarrhea. Anaerobe 15:244-248
16. Dial S, Alrasadi K, Manoukian C, Huang A, Menzies D (2004) Risk of Clostridium difficile diarrhea among hospital inpatients prescribed proton pump inhibitors: Cohort and case-control studies. CMAJ 171:33-38
17. Dial S, Delaney JA, Barkun AN, Suissa S (2005) Use of gastric acid-suppressive agents and the risk of communityacquired Clostridium difficile-associated disease. JAMA 294:2989-2995
18. Yearsley KA, Gilby LJ, Ramadas AV, Kubiak EM, Fone DL, Allison MC (2006) Proton pump inhibitor therapy is a risk factor for Clostridium difficile-associated diarrhoea. Aliment Pharmacol Ther 24:613-619
19. Wultanska D, Banaszkiewicz A, Radzikowski A, Obuch-Woszczatynski P, Mlynarczyk G, Brazier JS et al (2010) Clostridium difficile infection in Polish pediatric outpatients with inflammatory bowel disease. Eur J Clin Microbiol Infect Dis 29 (10):1265-1270. doi:10.1007/s10096-010-0997-9
20. Clayton EM, Rea MC, Shanahan F, Quigley EM, Kiely B, Hill C et al (2009) The vexed relationship between Clostridium difficile and inflammatory bowel disease: An assessment of carriage in an outpatient setting among patients in remission. Am J Gastroenterol 104:1162-1169
21. Huebner ES, Surawicz CM (2007) Clostridium difficile in relapse of inflammatory bowel disease. In: Katz S (ed) Inflammatory bowel disease: A practical approach, series #27. Practical Gastroenterology, January 2007, pp 42-47
22. Rodemann JF, Dubberke ER, Reske KA, Seo DH, Stone CD (2007) Incidence of Clostridium difficile infection in inflammatory bowel disease. Clin Gastroenterol Hepatol 5:339-344
23. Tremaine WJ (2007) Inflammatory bowel disease and Clostridium difficile-associated diarrhea: A growing problem. Clin Gastroenterol Hepatol 5:310-311
24. Issa M, Ananthakrishnan AN, Binion DG (2008) Clostridium difficile and inflammatory bowel disease. Inflamm Bowel Dis 14:1432-1442
25. Lewis SJ, Heaton KW (1997) Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol 32 (9):920-924
26. Katz DA, Lynch ME, Littenberg B (1996) Clinical prediction rules to optimize cytotoxin testing for Clostridium difficile in hospitalized patients with diarrhea. Am J Med 100 (5):487-495
27. Lin YC, Huang YT, Tsai PJ, Lee TF, Lee NY, Liao CH et al (2011) Antimicrobial susceptibilities and molecular epidemiology of clinical isolates of Clostridium difficile in Taiwan. Antimicrob Agents Chemother 55(4):1701-1705
28. Freeman J, Bauer MP, Baines SD, Corver J, Fawley WN, Goorhuis B et al (2010) The changing epidemiology of Clostridium difficile infections. Clin Microbiol Rev 23:529-549
29. Rudensky B, Rosner S, Sonnenblick M, van Dijk Y, Shapira E, Isaacsohn M (1993) The prevalence and nosocomial acquisition of Clostridium difficile in elderly hospitalized patients. Postgrad Med J 69(807):45-47
30. Wilkins TD, Lyerly DM (2003) Clostridium difficile testing: After 20 years, still challenging. J Clin Microbiol 41:531-534
31. Goldstein EJ, Polonsky J, Touzani M, Citron DM (2009) C. difficile infection (CDI) in a long-term acute care facility (LTAC). Anaerobe 15:241-243
32. Cohen SH, Gerding DN, Johnson S, Kelly CP, Loo VG, McDonald LC et al (2010) Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol 31:431-455
33. Kvach EJ, Ferguson D, Riska PF, Landry ML (2010) Comparison of BD GeneOhm Cdiff real-time PCR assay with a two-step algorithm and a toxin A/B enzyme-linked immunosorbent assay for diagnosis of toxigenic Clostridium difficile infection. J Clin Microbiol 48:109-114
34. Goorhuis A, Debast SB, Dutilh JC, van Kinschot CM, Harmanus C, Cannegieter SC et al (2011) Type-specific risk factors and outcome in an outbreak with 2 different Clostridium difficile types simultaneously in 1 hospital. Clin Infect Dis 53(9):860-869, Epub 2011 Sep 13