Expression and delivery of tetanus toxin fragment C fused to the N-terminal domain of SipB enhances specific immune responses in mice

Microbiology and Immunology

Volumn 56, Issue 9, 2012, Pages 595-604

  Jang, Jung Im ^a   Kim, Jin Seok ^a   Eom, Jeong Seon ^a   Kim, Hyeon Guk ^a,d   Kim, Bae Hoon ^a,e   Lim, Sangyong ^b   Bang, Iel Soo ^c   Park, Yong Keun ^a  

^a Korea University   (South Korea)

^b Korea Atomic Energy Research Institute   (South Korea)

^c Chosun University   (South Korea)

^d National Center for Lot Release Korea Food and Drug Administration   (South Korea)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Salmonella; SipB; Tetanus toxin fragment C; Type III secretion system

Indexed keywords

BACTERIAL PROTEIN; PLASMID VECTOR; PROTEIN SIPB; RECOMBINANT PROTEIN; SALMONELLOSIS VACCINE; T LYMPHOCYTE ANTIGEN; TETANUS TOXIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; BACTERIAL STRAIN; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; FEMALE; GENE CASSETTE; IMMUNOGENICITY; INFECTION PREVENTION; MOUSE; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; SALMONELLOSIS; SIGNAL TRANSDUCTION; SURFACE PROPERTY; TYPE III SECRETION SYSTEM; VACCINE PRODUCTION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODY FORMATION; BACTERIAL PROTEINS; CELL LINE; CELL MEMBRANE; CULTURE MEDIA; EPITOPES, T-LYMPHOCYTE; FEMALE; GENETIC VECTORS; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PLASMIDS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SALMONELLA TYPHIMURIUM; SALMONELLA VACCINES; TETANUS TOXIN; VACCINES, ATTENUATED;

BACTERIA (MICROORGANISMS); MUS; SALMONELLA; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM; SALMONELLA TYPHIMURIUM;

EID: 84865574451     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2012.00480.x     Document Type: Article

References (30)

1. Bachtiar E.W., Sheng K.C., Fifis T., Gamvrellis A., Plebanski M., Coloe P.J., Smooker P.M. (2003) Delivery of a heterologous antigen by a registered Salmonella vaccine (STM1). FEMS Microbiol Lett 227: 211-7.
2. Verma N.K., Ziegler H.K., Wilson M., Khan M., Safley S., Stocker B.A., Schoolnik G.K. (1995) Delivery of class I and class II MHC-restricted T-cell epitopes of listeriolysin of Listeria monocytogenes by attenuated Salmonella. Vaccine 13: 142-50.
3. Cheminay C., Mohlenbrink A., Hensel M. (2005) Intracellular Salmonella inhibit antigen presentation by dendritic cells. J Immunol 174: 2892-9.
4. Galan, J.E., Wolf-Watz H. (2006) Protein delivery into eukaryotic cells by type III secretion machines. Nature 444: 567-73.
5. Russmann H., Kubori T., Sauer J., Galan J.E. (2002) Molecular and functional analysis of the type III secretion signal of the Salmonella enterica InvJ protein. Mol Microbiol 46: 769-79.
6. Kotton C.N., Lankowski A.J., Scott N., Sisul D., Chen L.M., Raschke K., Borders G., Boaz M., Spentzou A., Galan J.E., Hohmann E.L. (2006) Safety and immunogenicity of attenuated Salmonella enterica serovar Typhimurium delivering an HIV-1 Gag antigen via the Salmonella Type III secretion system. Vaccine 24: 6216-24.
7. Russmann H., Igwe E.I., Sauer J., Hardt W.D., Bubert A., Geginat G. (2001) Protection against murine listeriosis by oral vaccination with recombinant Salmonella expressing hybrid Yersinia type III proteins. J Immunol 167: 357-65.
8. Lee V.T., Schneewind O. (2002) Yop fusions to tightly folded protein domains and their effects on Yersinia enterocolitica type III secretion. J Bacteriol 184: 3740-5.
9. Akeda Y., Galan J.E. (2005) Chaperone release and unfolding of substrates in type III secretion. Nature 437: 911-5.
10. Chen L.M., Briones G., Donis R.O., Galan, J.E. (2006) Optimization of the delivery of heterologous proteins by the Salmonella enterica serovar Typhimurium type III secretion system for vaccine development. Infect Immun 74: 5826-33.
11. Kim B.H., Kim H.G., Kim J.S., Jang J.I., Park Y.K. (2007) Analysis of functional domains present in the N-terminus of the SipB protein. Microbiology 153: 2998-3008.
12. Kim H.G., Kim B.H., Kim J.S., Eom J.S., Bang I.S., Bang S.H., Lee I.S., Park Y.K. (2008) N-terminal residues of SipB are required for its surface localization on Salmonella enterica serovar Typhimurium. Microbiology 154: 207-16.
13. Lee J.S., Shin K.S., Pan J.G., Kim C.J. (2000) Surface-displayed viral antigens on Salmonella carrier vaccine. Nature biotechnol 18: 645-8.
14. Rizos K., Lattemann C.T., Bumann D., Meyer T.F., Aebischer T. (2003) Autodisplay: efficacious surface exposure of antigenic UreA fragments from Helicobacter pylori in Salmonella vaccine strains. Infect Immun 71: 6320-8.
15. Turton K., Chaddock J.A., Acharya K.R. (2002) Botulinum and tetanus neurotoxins: structure, function and therapeutic utility. Trends Biochem Sci 27: 552-8.
16. Figueiredo D., Turcotte C., Frankel G., Li Y., Dolly O., Wilkin G., Marriott D., Fairweather N., Dougan G. (1995) Characterization of recombinant tetanus toxin derivatives suitable for vaccine development. Infect Immun 63: 3218-21.
17. Obert S., O'connor R.J., Schmid S., Hearing P. (1994) The adenovirus E4-6/7 protein transactivates the E2 promoter by inducing dimerization of a heteromeric E2F complex. Mol Cell Biol 14: 1333-46.
18. Giacomodonato M.N., Uzzau S., Bacciu D., Caccuri R., Sarnacki S.H., Rubino S., Cerquetti M.C. (2007) SipA, SopA, SopB, SopD and SopE2 effector proteins of Salmonella enterica serovar Typhimurium are synthesized at late stages of infection in mice. Microbiology 153: 1221-8.
19. Lee J.J., Sinha K.A., Harrison J.A., De Hormaeche R.D., Riveau G., Pierce R.J., Capron A., Wilson R.A., Khan C.M. (2000) Tetanus toxin fragment C expressed in live Salmonella vaccines enhances antibody responses to its fusion partner Schistosoma haematobium glutathione S-transferase. Infect Immun 68: 2503-12.
20. Demotz S., Lanzavecchia A., Eisel U., Niemann H., Widmann C., Corradin G. (1989) Delineation of several DR-restricted tetanus toxin T cell epitopes. J Immunol 142: 394-402.
21. Reece J.C., Geysen H.M., Rodda S.J. (1993) Mapping the major human T helper epitopes of tetanus toxin. The emerging picture. J Immunol 151: 6175-84.
22. Gahan M.E., Webster D.E., Wesselingh S.L., Strugnell R.A. (2007) Impact of plasmid stability on oral DNA delivery by Salmonella enterica serovar Typhimurium. Vaccine 25: 1476-83.
23. Galen J.E., Levine M.M. (2001) Can a 'flawless' live vector vaccine strain be engineered? Trends Microbiol 9: 372-6.
24. Kang H.Y., Srinivasan J., Curtiss R., 3rd (2002) Immune responses to recombinant pneumococcal PspA antigen delivered by live attenuated Salmonella enterica serovar typhimurium vaccine. Infect Immun 70: 1739-49.
25. Summers R.G., Knowles J.R. (1989) Illicit secretion of a cytoplasmic protein into the periplasm of Escherichia coli requires a signal peptide plus a portion of the cognate secreted protein. Demarcation of the critical region of the mature protein. J Biol Chem 264: 20074-81.
26. Yoon W.S., Chae Y.S., Hong J., Park Y.K. (2011) Antitumor therapeutic effects of a genetically engineered Salmonella typhimurium harboring TNF-alpha in mice. Applied Microbiol Biotechnol 89: 1807-19.
27. Galen J.E., Pasetti M.F., Tennant S., Ruiz-Olvera P., Sztein M.B., Levine M.M. (2009) Salmonella enterica serovar Typhi live vector vaccines finally come of age. Immunol cell biol 87: 400-12.
28. Mattei P.J., Faudry E., Job V., Izore T., Attree I., Dessen A. (2011) Membrane targeting and pore formation by the type III secretion system translocon. The FEBS journal 278: 414-26.
29. Xin W., Wanda S.Y., Li Y., Wang S., Mo H., Curtiss R., 3rd (2008) Analysis of type II secretion of recombinant pneumococcal PspA and PspC in a Salmonella enterica serovar Typhimurium vaccine with regulated delayed antigen synthesis. Infect Immun 76: 3241-54.
30. Chatfield S.N., Charles I.G., Makoff A.J., Oxer M.D., Dougan G., Pickard D., Slater D., Fairweather N.F. (1992) Use of the nirB promoter to direct the stable expression of heterologous antigens in Salmonella oral vaccine strains: development of a single-dose oral tetanus vaccine. Biotechnology (N Y) 10: 888-92.