Reducing power and iron chelating property of Terminalia chebula (Retz.) alleviates iron induced liver toxicity in mice

BMC Complementary and Alternative Medicine

Volumn 12, Issue , 2012, Pages

  Sarkar, Rhitajit ^a   Hazra, Bibhabasu ^a   Mandal, Nripendranath ^a  

^a BOSE INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; CARBONYL DERIVATIVE; CATALASE; DEFERASIROX; DNA; FERROZINE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HYDROXYPROLINE; IRON CHELATING AGENT; SUPEROXIDE DISMUTASE; TERMINALIA CHEBULA EXTRACT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; ENZYME BLOOD LEVEL; IN VITRO STUDY; IRON CHELATION; IRON OVERLOAD; LIPID OXIDATION; LIVER FIBROSIS; LIVER INJURY; LIVER TOXICITY; MOUSE; NONHUMAN; TERMINALIA CHEBULA;

EID: 84865573878     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-12-144     Document Type: Article

References (47)

1. Pulla Reddy AC, Lokesh BR. Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats. Toxicol 1996, 107:39-45.
2. Kruszewski M. Labile iron pool: the main determinant of cellular response to oxidative stress. Mutat Res 2003, 531:81-92. 10.1016/j.mrfmmm.2003.08.004, 14637247.
3. Goodman LS, Gilman A. The Pharmacological Basis of Therapeutics 2006, McGraw-Hill: New York, 11.
4. Liu ZD, Hider RC. Design of iron chelators with therapeutic application. Coord Chem Rev 2002, 232:151-171.
5. Birch N, Wang X, Chong HS. Iron chelators as therapeutic iron depletion agents. Expert Opin Ther Patents 2006, 16:1533-1556.
6. Kapoor LD. Handbook of ayurvedic medicinal plants 2001, CRC Press, Boca R, 5.
7. Lee HS, Won NH, Kim KH, Lee H, Jun W, Lee KW. Antioxidant effects of aqueous extract of Terminalia chebula in vivo and in vitro. Biol Pharm Bull 2005, 28:1639-1644. 10.1248/bpb.28.1639, 16141531.
8. Naik GH, Priyadarsini KI, Bhagirathi RG, Mishra B, Mishra KP, Banavalikar MM, Mohan H. In vitro antioxidant studies and free radical reactions of triphala, an ayurvedic formulation and its constituents. Phytother Res 2005, 19:582-586. 10.1002/ptr.1515, 16161061.
9. Cheng HY, Lin TC, Yu KH, Yang CM, Lin CC. Antioxidant and free radical scavenging activities of Terminalia chebula. Biol Pharm Bull 2003, 26:1331-1335. 10.1248/bpb.26.1331, 12951481.
10. Mahesh R, Bhuvana S, Begum VMH. Effect of Terminalia chebula aqueous extract on oxidative stress and antioxidant status in the liver and kidney of young and aged rats. Cell Biochem Funct 2009, 27:358-363. 10.1002/cbf.1581, 19548245.
11. Chang CL, Lin CS. Phytochemical Composition, Antioxidant Activity, and Neuroprotective Effect of Terminalia chebula Retzius Extracts. Evid Based Complement Altern Med 2011, 2012.
12. Saleem A, Husheem M, Harkonen P, Pihlaja K. Inhbition of cancer cell growth by crude extract and the phenolics of Terminalia chebula Retz. fruit. J Ethnopharmacol 2002, 81:327-336. 10.1016/S0378-8741(02)00099-5, 12127233.
13. Reddy DB, Reddy TC, Jyotsna G, Sharan S, Priya N, Lakshmipathi V, Reddanna P. Chebulagic acid, a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz. induces apoptosis in COLO-205 cell line. J Ethnopharmacol 2009, 124:506-512. 10.1016/j.jep.2009.05.022, 19481594.
14. Das ND, Jung KH, Park JH, Mondol MAM, Shin HJ, Lee HS, Park KS, Choi MR, Kim KS, Kim MS, Lee SR, Chai YG. Terminalia chebula Extract Acts as a Potential NF-κB Inhibitor in Human Lymphoblastic T Cells. Phytother Res 2011, 25:927-934. 10.1002/ptr.3398, 21509843.
15. Na M, Bae K, Kang SS, Min BS, Yoo JK, Kamiryo Y, Senoo Y, Yokoo S, Miwa N. Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruit. Phytother Res 2004, 18:737-741. 10.1002/ptr.1529, 15478203.
16. Rao NK, Nammi S. Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats. BMC Complement Altern Med 2006, 6:17. 10.1186/1472-6882-6-17, 1540439, 16677399.
17. Kim JH, Hong CO, Koo YC, Kim SJ, Lee KW. Oral Administration of Ethyl Acetate-Soluble Portion of Terminalia chebula Conferring Protection from Streptozotocin-Induced Diabetic Mellitus and Its Complications. Biol Pharm Bull 2011, 34:1702-1709. 10.1248/bpb.34.1702, 22040883.
18. Malekzadeh F, Ehsanifar H, Shahamat M, Levin M, Colwell RR. Antibacterial activity of black myrobalan (Terminalia chebula Retz.) against Helicobacter pylori. Int J Antimicrob Agents 2001, 18:85-88. 10.1016/S0924-8579(01)00352-1, 11463533.
19. Sharma P, Prakash T, Kotresha D, Ansari MA, Sahrm UR, Kumar B, Debnath J, Goli D. Antiulcerogenic activity of Terminalia chebula fruit in experimentally induced ulcer in rats. Pharm Biol 2011, 49:262-268. 10.3109/13880209.2010.503709, 21323478.
20. Gopi KS, Gopala Reddy A, Jyothi K, Anil Kumar B. Acetaminophen-induced Hepato- and Nephrotoxicity and Amelioration by Silymarin and Terminalia chebula in Rats. Toxicol International 2010, 17:64-66.
21. Grover IS, Bala S. Antimutagenic activity of T. chebula (myroblan) in Salmonella typhimurium. Ind J Exp Biol 1992, 30(4):339-341.
22. Cook NC, Samman S. Flavonoids-chemistry, metabolism, cardioprotective effects, and dietary sources. J Nutr Biochem 1996, 7:66-76.
23. Hazra B, Sarkar R, Biswas S, Mandal N. Comparative study of the antioxidant and reactive oxygen species scavenging properties in the extracts of the fruits of Terminalia chebula, Terminalia belerica and Emblica officinalis. BMC Complement Altern Med 2010, 10:20. 10.1186/1472-6882-10-20, 2887379, 20462461.
24. Bridges KR, Hoffman KE. The effects of ascorbic acid on the intracellular metabolism of iron and ferritin. J Biol Chem 1986, 261:14273-14277.
25. Haro-Vicente JF, Martínez-Graciá C, Ros G. Optimisation of in vitro measurement of available iron from different fortificants in citric fruit juices. Food Chem 2006, 98:639-648.
26. Hermes-Lima M, Nagy E, Ponka P, Schulman HM. The iron chelator pyridoxal isonicotinoyl hydrazone (PIH) protects plasmid pUC-18 DNA against .OH mediated strand breaks. Free Radical Bio Med 1998, 25:875-880.
27. Lowry OH, Roesborough MJ, Farr AL, Randall RJ. Protein measurement with Folin-Phenol reagent. J Biol Chem 1951, 193:265-275.
28. Kakkar P, Das B, Viswanathan PN. A modified spectrophotometric assay of superoxide dismutase. Indian J Biochem Biophys 1984, 21:130-132.
29. Bonaventura J, Schroeder WA, Fang S. Human erythrocyte catalase: an improved method of isolation and a re-evaluation of reported properties. Arch Biochem Biophys 1972, 150:606-617. 10.1016/0003-9861(72)90080-X, 5044042.
30. Habig WH, Pabst MJ, Jakoby WB. Glutathione S transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974, 249:7130-7139.
31. Ellman GL. Tissue sulfhydryl group. Arch Biochem Biophys 1959, 82:70-77. 10.1016/0003-9861(59)90090-6, 13650640.
32. Buege JA, Aust SD. Microsomal lipid per oxidation. Methods Enzymol 1978, 52:302-310.
33. Reznick AZ, Packer L. Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Methods Enzymol 1994, 233:357-363.
34. Bergman I, Loxley R. Two improved and simplified methods for the spectrophotometric determination of hydroxyproline. Anal Chem 1963, 35:1961-1965.
35. Kivirikko KI, Laitinen O, Prockop DJ. Modifications of a specific assay for hydroxyproline in urine. Anal Biochem 1967, 19:249-255. 10.1016/0003-2697(67)90160-1, 6048697.
36. Barry M, Sherlock S. Measurement of liver-iron concentration in needle biopsy specimens. Lancet 1971, 297:100-103.
37. Hynes MJ, Coinceanainn M. Investigation of the release of iron from ferritin by naturally occurring antioxidants. J Inorg Biochem 2002, 90:18-21. 10.1016/S0162-0134(02)00383-5, 12009251.
38. Bonkovsky HL. Iron and the liver. Am J Med Sci 1991, 301:32-43. 10.1097/00000441-199101000-00006, 1847276.
39. Sayre LM, Moreira PI, Smith MA, Perry G. Metal ions and oxidative protein modification in neurological disease. Ann Ist Super Sanita 2005, 41:143-164.
40. Rothman RJ, Serroni A, Farber JL. Cellular pool of transient ferric iron, chelatable by deferoxamine and distinct from ferritin, that is involved in oxidative cell injury. Mol Pharmacol 1992, 42:703-710.
41. Galleano M, Simontacchi M, Puntarulo S. Nitric oxide and iron: effect of iron overload on nitric oxide production in endotoxemia. Mol Aspects Med 2004, 25:141-154. 10.1016/j.mam.2004.02.015, 15051323.
42. Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev 1998, 78:547-581.
43. Bonkowsky HL, Healey JF, Sinclair PR, Sinclair JF, Pomeroy JS. Iron and the liver. Acute and long-term effects of iron-loading on hepatic haem metabolism. Biochem J 1981, 196:57-64. 1162967, 7306080.
44. Dalle-Donne I, Rossi R, Giustarini D, Milzani A, Colombo R. Protein carbonyl groups as biomarkers of oxidative stress. Clin Chim Acta 2003, 329:23-28. 10.1016/S0009-8981(03)00003-2, 12589963.
45. Ramm GA, Ruddell RG. Hepatotoxicity of iron overload: mechanisms of iron-induced hepatic fibrogenesis. Semin Liver Dis 2005, 25:433-449. 10.1055/s-2005-923315, 16315137.
46. Harrison PM. Ferritin: an iron-storage molecule. Sem Hematol 1977, 14:55-70.
47. O'Brien RT. Ascorbic acid enhancement of desferrioxamine-induced urinary iron excretion in thalassemia major. Ann NY Acad Sci 1974, 232:221-225. 10.1111/j.1749-6632.1974.tb20588.x, 4528431.