Tumor cells can evade dependence on autophagy through adaptation

Biochemical and Biophysical Research Communications

Volumn 425, Issue 3, 2012, Pages 684-688

  Ding, Wen Xing ^a   Chen, Xi ^b,c   Yin, Xiao Ming ^b  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Anticancer therapy; Autophagy; Proteasome inhibitors

Indexed keywords

AUTOPHAGY PROTEIN 5; BECLIN 1; PROTEASOME; RAS PROTEIN; SMALL INTERFERING RNA;

ARTICLE; AUTOPHAGY; CELL INVASION; CELL LINE; CONTROLLED STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL;

APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE, TUMOR; GENE KNOCKDOWN TECHNIQUES; HUMANS; MEMBRANE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASMS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; RNA, SMALL INTERFERING;

EID: 84865561104     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.07.090     Document Type: Article

References (20)

1. Ding W.X., Yin X.M. Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome. Autophagy 2008, 4:141-150.
2. Adams J., Palombella V.J., Sausville E.A., Johnson J., Destree A., Lazarus D.D., Maas J., Pien C.S., Prakash S., Elliott P.J. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 1999, 59:2615-2622.
3. Fang H.T., Zhang B., Pan X.F., Gao L., Zhen T., Zhao H.X., Ma L., Xie J., Liu Z., Yu X.J., Cheng X., Feng T.T., Zhang F.X., Yang Y., Hu Z.G., Sheng G.Q., Chen Y.L., Chen S.J., Chen Z., Zhou G.B. Bortezomib interferes with C-KIT processing and transforms the t (8;21)-generated fusion proteins into tumor-suppressing fragments in leukemia cells. Proc. Nat. Acad. Sci. U.S.A. 2012, 109:2521-2526.
4. Kondo Y., Kondo S. Autophagy and cancer therapy. Autophagy 2006, 2:85-90.
5. Kim I., Rodriguez-Enriquez S., Lemasters J.J. Selective degradation of mitochondria by mitophagy. Arch. Biochem. Biophys. 2007, 462:245-253.
6. Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
7. Ding W.X., Ni H.M., Gao W., Chen X., Kang J.H., Stolz D.B., Liu J., Yin X.M. Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy. Mol. Cancer Ther. 2009, 8:2036-2045.
8. Kuma A., Hatano M., Matsui M., Yamamoto A., Nakaya H., Yoshimori T., Ohsumi Y., Tokuhisa T., Mizushima N. The role of autophagy during the early neonatal starvation period. Nature 2004, 432:1032-1036.
9. Liu J., Yang G., Thompson-Lanza J.A., Glassman A., Hayes K., Patterson A., Marquez R.T., Auersperg N., Yu Y., Hahn W.C., Mills G.B., Bast R.C. A genetically defined model for human ovarian cancer. Cancer Res. 2004, 64:1655-1663.
10. Zeng X., Overmeyer J.H., Maltese W.A. Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking. J. Cell Sci. 2006, 119:259-270.
11. Ding W.X., Ni H.M., DiFrancesca D., Stolz D.B., Yin X.M. Bid-dependent generation of oxygen radicals promotes death receptor activation-induced apoptosis in murine hepatocytes. Hepatology 2004, 40:403-413.
12. Mathew R., Karantza-Wadsworth V., White E. Role of autophagy in cancer. Nat. Rev. Cancer 2007, 7:961-967.
13. Levine B. Cell biology: autophagy and cancer. Nature 2007, 446:745-747.
14. Lock R., Roy S., Kenific C.M., Su J.S., Salas E., Ronen S.M., Debnath J. Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol. Biol. Cell 2011, 22:165-178.
15. Guo J.Y., Chen H.Y., Mathew R., Fan J., Strohecker A.M., Karsli-Uzunbas G., Kamphorst J.J., Chen G., Lemons J.M., Karantza V., Coller H.A., Dipaola R.S., Gelinas C., Rabinowitz J.D., White E. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev. 2011, 25:460-470.
16. Wei H., Wei S., Gan B., Peng X., Zou W., Guan J.L. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes Dev. 2011, 25:1510-1527.
17. Kim M.J., Woo S.J., Yoon C.H., Lee J.S., An S., Choi Y.H., Hwang S.G., Yoon G., Lee S.J. Involvement of autophagy in oncogenic K-Ras-induced malignant cell transformation. J. Biol. Chem. 2011, 286:12924-12932.
18. Mathew R., Kongara S., Beaudoin B., Karp C.M., Bray K., Degenhardt K., Chen G., Jin S., White E. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev. 2007, 21:1367-1381.
19. Elgendy M., Sheridan C., Brumatti G., Martin S.J. Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival. Mol. Cell 2011, 42:23-35.
20. Wu S.Y., Lan S.H., Cheng D.E., Chen W.K., Shen C.H., Lee Y.R., Zuchini R., Liu H.S. Ras-related tumorigenesis is suppressed by BNIP3-mediated autophagy through inhibition of cell proliferation. Neoplasia 2011, 13:1171-1182.