α-Tocopherol (vitamin E) stimulates cyclic AMP production in human peripheral mononuclear cells and alters immune function

Molecular Immunology

Volumn 53, Issue 3, 2013, Pages 173-178

  Salinthone, Sonemany ^a,b   Kerns, Amelia R ^a   Tsang, Vivian ^a   Carr, Daniel W ^a,c  

^a PORTLAND VA MEDICAL CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

C Tocopherol; CAMP; Chemokine; Cytokine; Inflammation; Signal transduction

Indexed keywords

ALPHA TOCOPHEROL; CHEMOKINE; CYCLIC AMP; CYTOKINE; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN E RECEPTOR 4;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; MONONUCLEAR CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ALPHA-TOCOPHEROL; ANTIOXIDANTS; CELLS, CULTURED; CHEMOKINE CCL5; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMMUNOLOGIC FACTORS; INFLAMMATION MEDIATORS; INTERLEUKIN-17; INTERLEUKIN-2; INTERLEUKIN-8; LEUKOCYTES, MONONUCLEAR; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; SIGNAL TRANSDUCTION;

EID: 84865554539     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2012.08.005     Document Type: Article

References (22)

1. 2+/calmodulin-dependent protein kinase IV. Molecular Endocrinology 1997, 11:725-737.
2. Bartosik-Psujek H., Belniak E., Mitosek-Szewczyk K., Dobosz B., Stelmasiak Z. Interleukin-8 and RANTES levels in patients with relapsing-remitting multiple sclerosis (RR-MS) treated with cladribine. Acta Neurologica Scandinavica 2004, 109:390-392.
3. Betz M., Fox B.S. Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. Journal of Immunology 1991, 146:108-113.
4. Borger P., Postma D.S., Vellenga E., Kauffman H.F. Regulation of asthma-related T-cell cytokines by the cyclic AMP-dependent signalling pathway. Clinical and Experimental Allergy 2000, 30:920-926.
5. Han S.N., Wu D., Ha W.K., Beharka A., Smith D.E., Bender B.S., Meydani S.N. Vitamin E supplementation increases T helper 1 cytokine production in old mice infected with influenza virus. Immunology 2000, 100:487-493.
6. Joshi P.C., Zhou X., Cuchens M., Jones Q. Prostaglandin E2 suppressed IL-15-mediated human NK cell function through down-regulation of common gamma-chain. Journal of Immunology 2001, 166:885-891.
7. Kamenetsky M., Middelhaufe S., Bank E.M., Levin L.R., Buck J., Steegborn C. Molecular details of cAMP generation in mammalian cells: a tale of two systems. Journal of Molecular Biology 2006, 362:623-639.
8. Kurts C. Th17 cells: a third subset of CD4+ T effector cells involved in organ-specific autoimmunity. Nephrology, Dialysis, Transplantation 2008, 23:816-819.
9. Marko M.G., Ahmed T., Bunnell S.C., Wu D., Chung H., Huber B.T., Meydani S.N. Age-associated decline in effective immune synapse formation of CD4(+) T cells is reversed by vitamin E supplementation. Journal of Immunology 2007, 178:1443-1449.
10. Matlhagela K., Taub M. Involvement of EP1 and EP2 receptors in the regulation of the Na, K-ATPase by prostaglandins in MDCK cells. Prostaglandins and Other Lipid Mediators 2006, 79:101-113.
11. Roder J.C., Argov S., Klein M., Petersson C., Kiessling R., Andersson K., Hansson M. Target-effector cell interaction in the natural killer cell system. V. Energy requirements, membrane integrity, and the possible involvement of lysosomal enzymes. Immunology 1980, 40:107-116.
12. Salinthone S., Schillace R.V., Marracci G.H., Bourdette D.N., Carr D.W. Lipoic acid stimulates cAMP production via the EP2 and EP4 prostanoid receptors and inhibits IFN gamma synthesis and cellular cytotoxicity in NK cells. Journal of Neuroimmunology 2008, 199:46-55.
13. Salinthone S., Yadav V., Schillace R.V., Bourdette D.N., Carr D.W. Lipoic acid attenuates inflammation via cAMP and protein kinase A signaling. PLoS One 2010, 5(9):e13058. 10.1371/journal.pone.0013058.
14. Sanchez T., Moreno J.J. Role of EP(1) and EP(4) PGE(2) subtype receptors in serum-induced 3T6 fibroblast cycle progression and proliferation. American Journal of Physiology - Cell Physiology 2002, 282:C280-C288.
15. Schillace R.V., Pisenti N., Pattamanuch N., Galligan S., Marracci G.H., Bourdette D.N., Carr D.W. Lipoic acid stimulates cAMP production in T lymphocytes and NK cells. Biochemical and Biophysical Research Communications 2007, 354:259-264.
16. Smith A.D., Botero S., Shea-Donohue T., Urban J.F. The pathogenicity of an enteric Citrobacter rodentium infection is enhanced by deficiencies in the antioxidants selenium and vitamin E. Infection and Immunity 2011, 79:1471-1478.
17. Snijdewint F.G., Kapsenberg M.L., Wauben-Penris P.J., Bos J.D. Corticosteroids class-dependently inhibit in vitro Th1- and Th2-type cytokine production. Immunopharmacology 1995, 29:93-101.
18. Stockinger B., Veldhoen M. Differentiation and function of Th17 T cells. Current Opinion in Immunology 2007, 19:281-286.
19. Sugimoto Y., Narumiya S. Prostaglandin E receptors. Journal of Biological Chemistry 2007, 282:11613-11617.
20. Walker W., Rotondo D. Prostaglandin E2 is a potent regulator of interleukin-12- and interleukin-18-induced natural killer cell interferon-gamma synthesis. Immunology 2004, 111:298-305.
21. Wu D., Meydani S.N. Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention. Journal of Leukocyte Biology 2008, 84:900-914.
22. Wu D., Mura C., Beharka A.A., Han S.N., Paulson K.E., Hwang D., Meydani S.N. Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E. American Journal of Physiology 1998, 275:C661-C668.