Etanercept treatment in Fanconi anaemia; combined US and Italian experience

British Journal of Haematology

Volumn 158, Issue 6, 2012, Pages 809-811

  Mehta, Parinda A ^a   Svahn, Johanna ^b   Davies, Stella M ^a   Pang, Qishen ^a   Harris, Richard ^a   Ghezzi, Pietro ^c   Lanza, Tiziana ^b   Ferretti, Elisa ^b   Barabino, Paola ^b   Mueller, Robin ^a   Dufour, Carlo ^b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b G GASLINI INSTITUTE   (Italy)

^c BRIGHTON AND SUSSEX MEDICAL SCHOOL   (United Kingdom)

Author keywords

Cytokine therapy; Etanercept; Fanconi Anaemia; Marrow failure; Tumour necrosis factor

Indexed keywords

ETANERCEPT; HEMOGLOBIN; STEROID; TUMOR NECROSIS FACTOR ALPHA;

ADULT; BONE MARROW DEPRESSION; CHILD; CLINICAL ARTICLE; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; FANCONI ANEMIA; FEMALE; FURUNCULOSIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMOGLOBIN BLOOD LEVEL; HUMAN; INJECTION SITE CONTUSION; INJECTION SITE PAIN; ITALY; LETTER; MALE; NEUTROPHIL COUNT; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RHEUMATOID ARTHRITIS; SCHOOL CHILD; THROMBOCYTE COUNT; TREATMENT RESPONSE; UNITED STATES; VASCULITIS;

ABNORMALITIES, MULTIPLE; CHILD; CLINICAL TRIALS AS TOPIC; FANCONI ANEMIA; FEMALE; HEMOGLOBINURIA, PAROXYSMAL; HUMANS; IMMUNOGLOBULIN G; ITALY; MALE; RECEPTORS, TUMOR NECROSIS FACTOR; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA; UNITED STATES; YOUNG ADULT;

EID: 84865554337     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2012.09250.x     Document Type: Letter

References (10)

1. Dufour, C., Corcione, A., Svahn, J., Haupt, R., Battilana, N. & Pistoia, V. (2001) Interferon gamma and tumour necrosis factor alpha are overexpressed in bone marrow T lymphocytes from paediatric patients with aplastic anaemia. British Journal of Haematology, 115, 1023-1031.
2. Dufour, C., Corcione, A., Svahn, J., Haupt, R., Poggi, V., Beka'ssy, A.N., Scime, R., Pistorio, A. & Pistoia, V. (2003) TNF-alpha and IFN-gamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro. Blood, 102, 2053-2059.
3. Haneline, L.S., Broxmeyer, H.E., Cooper, S., Hangoc, G., Carreau, M., Buchwald, M. & Clapp, D.W. (1998) Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac-/- mice. Blood, 91, 4092-4098.
4. Keystone, E.C., Schiff, M.H., Kremer, J.M., Kafka, S., Lovy, M., DeVries, T. & Burge, D.J. (2004) Once-weekly administration of 50 mg etanercept in patients with active rheumatoid arthritis: results of a multicenter, randomized, double-blind, placebo-controlled trial. Arthritis and Rheumatism, 50, 353-363.
5. Li, J., Sejas, D.P., Zhang, X., Qiu, Y., Nattamai, K.J., Rani, R., Rathbun, K.R., Geiger, H., Williams, D.A., Bagby, G.C. & Pang, Q. (2007) TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells. The Journal of Clinical Investigation, 117, 3283-3295.
6. Lovell, D.J., Giannini, E.H., Reiff, A., Cawkwell, G.D., Silverman, E.D., Nocton, J.J., Stein, L.D., Gedalia, A., Ilowite, N.T., Wallace, C.A., Whitmore, J. & Finck, B.K. (2000) Etanercept in children with polyarticular juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group. New England Journal of Medicine, 342, 763-769.
7. Moreland, L.W., Baumgartner, S.W., Schiff, M.H., Tindall, E.A., Fleischmann, R.M., Weaver, A.L., Ettlinger, R.E., Cohen, S., Koopman, W.J., Mohler, K., Widmer, M.B. & Blosch, C.M. (1997) Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. New England Journal of Medicine, 337, 141-147.
8. Otsuki, T., Nagakura, S., Wang, J., Bloom, M., Grompe, M. & Liu, J.M. (1999) Tumor necrosis factor-alpha and CD95 ligation suppress erythropoiesis in Fanconi anemia C gene knockout mice. Journal of Cellular Physiology, 179, 79-86.
9. Pang, Q., Keeble, W., Christianson, T.A., Faulkner, G.R. & Bagby, G.C. (2001) FANCC interacts with Hsp70 to protect hematopoietic cells from IFN-gamma/TNF-alpha- mediated cytotoxicity. EMBO Journal, 20, 4478-4489.
10. Rosselli, F., Sanceau, J., Gluckman, E., Wietzerbin, J. & Moustacchi, E. (1994) Abnormal lymphokine production: a novel feature of the genetic disease Fanconi anemia. II. In vitro and in vivo spontaneous overproduction of tumor necrosis factor alpha. Blood, 83, 1216-1225.