Exercise training leads to a reduction of elevated myostatin levels in patients with chronic heart failure

European Journal of Preventive Cardiology

Volumn 19, Issue 3, 2012, Pages 404-411

  Lenk, Karsten ^a   Erbs, Sandra ^a   Höllriegel, Robert ^a   Beck, Ephraim ^a   Linke, Axel ^a   Gielen, Stephan ^a   Winkler, Sven Möbius ^a   Sandri, Marcus ^a   Hambrecht, Rainer ^b   Schuler, Gerhard ^a   Adams, Volker ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b Klinikum Links der Weser   (Germany)

Author keywords

cachexia; chronic heart failure; exercise training; Myostatin; NYHA III; skeletal muscle

Indexed keywords

ACETYLSALICYLIC ACID; ALDOSTERONE ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CLOPIDOGREL; DIGITALIS; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MESSENGER RNA; MYOSTATIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EXERCISE; GENE EXPRESSION; HEART FAILURE; HUMAN; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SEDENTARY LIFESTYLE; SKELETAL MUSCLE;

AGED; BICYCLING; BIOLOGICAL MARKERS; CHI-SQUARE DISTRIBUTION; CHRONIC DISEASE; DOWN-REGULATION; EXERCISE THERAPY; GERMANY; HEART FAILURE; HUMANS; MALE; MIDDLE AGED; MUSCLE, SKELETAL; MYOSTATIN; RNA, MESSENGER; SEDENTARY LIFESTYLE; TIME FACTORS; TREATMENT OUTCOME;

EID: 84865552110     PISSN: 20474873     EISSN: None     Source Type: Journal    
DOI: 10.1177/1741826711402735     Document Type: Article

References (23)

1. Levine B, Kalman J, Mayer L, Fillit HM, Packer M. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med. 1990 ; 323: 236-241 (Pubitemid 20225044)
2. Katz SD, Rao R, Berman JW, Schwarz M, Demopoulos L, Bijou R, et al. Pathophysiological correlates of increased serum tumor necrosis factor in patients with congestive heart failure. Relation to nitric oxide-dependent vasodilation in the forearm circulation. Circulation. 1994 ; 90: 12-16 (Pubitemid 24203656)
3. Torre-Amione G, Kapadia S, Lee J, Durand JB, Bies RD, Young JB, et al. Tumor necrosis factor-alpha and tumor necrosis factor receptors in the failing human heart. Circulation. 1996 ; 93: 704-711
4. Anker SD, Ponikowski P, Varney S, Chua TP, Clark AL, Webb-Peploe KM, et al. Wasting as independent risk factor for mortality in chronic heart failure. Lancet. 1997 ; 349: 1050-1053 (Pubitemid 27158249)
5. Gonzalez-Cadavid NF, Taylor WE, Yarasheski K, Sinha-Hikim I, Ma K, Ezzat S, et al. Organization of the human Myostatin gene and expression in healthy men and HIV infected men with muscle wasting. Proc Natl Acad Sci USA. 1998 ; 95: 14938-14943 (Pubitemid 29003735)
6. Acharyya S, Guttridge DC. Cancer cachexia signaling pathways continue to emerge yet much still points to the proteasome. Clin Cancer Res. 2007 ; 13: 1356-1361 (Pubitemid 46450422)
7. McPherron AC, Lawler AM, Lee S-J. Regulation of skeletal muscle mass in mice by a new TGF- superfamily member. Nature. 1997 ; 387: 83-90 (Pubitemid 27202654)
8. Zimmers TA, Davies MV, Koniaris LG, Haynes P, Esquela AF, Tomkinson KN, et al. Induction of cachexia in mice by systemically administered myostatin. Science. 2002 ; 296: 1486-1488 (Pubitemid 34553097)
9. Lenk K, Schur R, Linke A, Erbs S, Matsumoto Y, Adams V, et al. Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in a chronic heart failure model. Eur J Heart Fail. 2009 ; 11: 342-348
10. Gielen S, Adams V, Möbius-Winkler S, Linke A, Erbs S, Yu J, et al. Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. J Am Coll Cardiol. 2003 ; 42: 861-868 (Pubitemid 37059745)
11. Hambrecht R, Gielen S, Linke A, Fiehn E, Yu J, Walther C, et al. Effects of exercise training on left ventricular function and peripheral resistance in patients with chronic heart failure: A randomized trial. JAMA. 2000 ; 283: 3095-3101 (Pubitemid 30399720)
12. Coffey VG, Shield A, Canny BJ, Carey KA, Cameron-Smith D, Hawley JA. Interaction of contractile activity and training history on mRNA abundance in skeletal muscle from trained athletes. Am J Physiol Endocrinol Metab. 2006 ; 290: E849 - E855
13. Costa A, Dalloul H, Hegyesi H, Apor P, Csende Z, Racz L, et al. Impact of repeated bouts of eccentric exercise on myogenic gene expression. Eur J Appl Physiol. 2007 ; 101: 427-436 (Pubitemid 47500361)
14. Erbs S, Höllriegel R, Linke A, Beck EB, Adams V, Gielen S, et al. Exercise training in patients with advanced chronic heart failure (NYHA IIIb) promotes restoration of peripheral vasomotor function, induction of endogenous regeneration, and improvement of left ventricular function. Circ Heart Fail. 2010 ; 3: 486-494
15. Mezzani A, Agostoni P, Cohen-Solal A, Corrà U, Jegier A, Kouidi E, et al. Standards for the use of cardiopulmonary exercise testing for the functional evaluation of cardiac patients: a report from the Exercise Physiology Section of the European Association for Cardiovascular Prevention and Rehabilitation. Eur J Cardiovasc Prev Rehabil. 2009 ; 16: 249-267
16. Bergstrom J. Percutaneous needle biopsy of skeletal muscle in physiological and clinical research. Scand J Clin Lab Invest. 1975 ; 35: 609-616
17. Adams V, Linke A, Gielen S, Erbs S, Hambrecht R, Schuler G. Modulation of Murf-1 and MAFbx expression in the myocardium by physical exercise training. Eur J Cardiovasc Prev Rehabil. 2008 ; 15: 293-299
18. Anker SD, Negassa A, Coats AJ, Afzal R, Poole-Wilson PA, Cohn JN, et al. Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: an observational study. Lancet. 2003 ; 361: 1077-1083 (Pubitemid 36369559)
19. Plant PJ, Brooks D, Faughnan M, Bayley T, Bain J, Singer L, et al. Cellular markers of muscle atrophy in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2010 ; 42: 461-471
20. Heineke J, Auger-Messier M, Xu J, Sargent M, York A, Welle S, et al. Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure. Circulation. 2010 ; 121: 419-425
21. George I, Bish LT, Kamalakkannan G, Petrilli CM, Oz MC, Naka Y, et al. Myostatin activation in patients with advanced heart failure and after mechanical unloading. Eur J Heart Fail. 2010 ; 12: 444-453
22. Jones SW, Hill RJ, Krasney PA, O'Conner B, Peirce N, Greenhaff PL. Disuse atrophy and exercise rehabilitation in humans profoundly affects the expression of genes associated with the regulation of skeletal muscle mass. FASEB J. 2004 ; 18: 1025-1027 (Pubitemid 39561513)
23. Willoughby DS. Effects of heavy resistance training on myostatin mRNA and protein expression. Med Sci Sports Exerc. 2004 ; 36: 574-582 (Pubitemid 38452028)