Hippocampal nitric oxide contributes to sex difference in affective behaviors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 35, 2012, Pages 14224-14229

  Hu, Yao ^a   Wu, Dan Lian ^a   Luo, Chun Xia ^a   Zhu, Li Juan ^a   Zhang, Jing ^a   Wu, Hai Yin ^a   Zhu, Dong Ya ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Chronic mild stress; Corticosterone; Depressive behaviors; Gender difference; Psychiatric disorders

Indexed keywords

CORTICOSTERONE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DIETHYLENETRIAMINE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GLUCOCORTICOID; MINERALOCORTICOID RECEPTOR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR MODIFICATION; CONTROLLED STUDY; DENTATE GYRUS; DEPRESSION; DOWN REGULATION; ENZYME SYNTHESIS; FEMALE; HIPPOCAMPUS; HORMONE RELEASE; HORMONE SUBSTITUTION; IMMOBILIZATION; IN VIVO STUDY; LATENT PERIOD; LIFE EVENT; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SEX DIFFERENCE; STRESS; SUBSTITUTION THERAPY; UPREGULATION;

ANDROGENS; ANIMALS; BEHAVIOR, ANIMAL; CHRONIC DISEASE; CORTICOSTERONE; CREB-BINDING PROTEIN; DEPRESSIVE DISORDER; ESTRADIOL; ESTROGENS; FEMALE; HIPPOCAMPUS; MALE; MICE; MICE, INBRED STRAINS; MOOD DISORDERS; NEURONS; NITRIC OXIDE; ORGAN CULTURE TECHNIQUES; OVARIECTOMY; SEX CHARACTERISTICS; STRESS, PSYCHOLOGICAL; TESTOSTERONE;

MUS; RODENTIA;

EID: 84865535317     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1207461109     Document Type: Article

References (30)

1. Duric V, et al. (2010) A negative regulator of MAP kinase causes depressive behavior. Nat Med 16:1328-1332.
2. Ressler KJ, Mayberg HS (2007) Targeting abnormal neural circuits in mood and anxiety disorders: From the laboratory to the clinic. Nat Neurosci 10:1116-1124.
3. Aragam N, Wang KS, Pan Y (2011) Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples. J Affect Disord 133:516-521.
4. Essau CA, Lewinsohn PM, Seeley JR, Sasagawa S (2010) Gender differences in the developmental course of depression. J Affect Disord 127:185-190.
5. McLean CP, Asnaani A, Litz BT, Hofmann SG (2011) Gender differences in anxiety disorders: Prevalence, course of illness, comorbidity and burden of illness. J Psychiatr Res 45:1027-1035.
6. Binder EB, et al. (2009) HPA-axis regulation at in-patient admission is associated with antidepressant therapy outcome in male but not in female depressed patients. Psychoneuroendocrinology 34:99-109.
7. Young EA, Midgley AR, Carlson NE, Brown MB (2000) Alteration in the hypothalamic-pituitary- ovarian axis in depressed women. Arch Gen Psychiatry 57:1157-1162.
8. Zhou QG, et al. (2007) Neuronal nitric oxide synthase contributes to chronic stress-induced depression in mice. J Neurochem 103:1843-1854.
9. Zhou QG, et al. (2011) Hippocampal neuronal nitric oxide synthase mediates the stress-related depressive behaviors of glucocorticoids by downregulating glucocorticoid receptor. J Neurosci 31:7579-7590.
10. O'Donovan MC, et al.; Molecular Genetics of Schizophrenia Collaboration (2008) Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 40:1053-1055.
11. Nelson RJ, et al. (1995) Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase. Nature 378:383-386.
12. Zhang J, et al. (2010) Neuronal nitric oxide synthase alteration accounts for the role of 5-HT1A receptor in modulating anxiety-related behaviors. J Neurosci 30:2433-2441.
13. MacQueen G, Frodl T (2011) The hippocampus in major depression: Evidence for the convergence of the bench and bedside in psychiatric research? Mol Psychiatry 16:252-264.
14. Palumbo ML, et al. (2007) Loss of hippocampal neuronal nitric oxide synthase contributes to the stress-related deficit in learning and memory. J Neurochem 102:261-274.
15. Mukai H, et al. (2010) Modulation of synaptic plasticity by brain estrogen in the hippocampus. Biochim Biophys Acta 1800:1030-1044.
16. Santarelli L, et al. (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301:805-809.
17. Prossnitz ER, Barton M (2011) The G-protein-coupled estrogen receptor GPER in health and disease. Nat Rev Endocrinol 7:715-726.
18. Solomon MB, Herman JP (2009) Sex differences in psychopathology: Of gonads, adrenals and mental illness. Physiol Behav 97:250-258.
19. Martinowich K, Manji H, Lu B (2007) New insights into BDNF function in depression and anxiety. Nat Neurosci 10:1089-1093.
20. Revest JM, et al. (2005) The MAPK pathway and Egr-1 mediate stress-related behavioral effects of glucocorticoids. Nat Neurosci 8:664-672.
21. Kitraki E, Kremmyda O, Youlatos D, Alexis MN, Kittas C (2004) Gender-dependent alterations in corticosteroid receptor status and spatial performance following 21 days of restraint stress. Neuroscience 125:47-55.
22. Voleti B, Tanis KQ, Newton SS, Duman RS (2012) Analysis of target genes regulated by chronic electroconvulsive therapy reveals role for Fzd6 in depression. Biol Psychiatry 71:51-58.
23. Shansky RM, et al. (2004) Estrogen mediates sex differences in stress-induced prefrontal cortex dysfunction. Mol Psychiatry 9:531-538.
24. Freeman EW, Sammel MD, Lin H, Nelson DB (2006) Associations of hormones and menopausal status with depressed mood in women with no history of depression. Arch Gen Psychiatry 63:375-382.
25. Mahon PB, et al.; NIMH Genetics Initiative Bipolar Disorder Consortium; BiGS Consortium (2009) Genome-wide linkage and follow-up association study of postpartum mood symptoms. Am J Psychiatry 166:1229-1237.
26. Cohen LS, et al. (2003) Short-term use of estradiol for depression in perimenopausal and postmenopausal women: a preliminary report. Am J Psychiatry 160:1519-1522.
27. Parry BL (2008) Perimenopausal depression. Am J Psychiatry 165:23-27.
28. Zhang JQ, Cai WQ, Zhou DS, Su BY (2002) Distribution and differences of estrogen receptor beta immunoreactivity in the brain of adult male and female rats. Brain Res 935:73-80.
29. Murphy DD, Segal M (1997) Morphological plasticity of dendritic spines in central neurons is mediated by activation of cAMP response element binding protein. Proc Natl Acad Sci USA 94:1482-1487.
30. Auger AP, Hexter DP, McCarthy MM (2001) Sex difference in the phosphorylation of cAMP response element binding protein (CREB) in neonatal rat brain. Brain Res 890:110-117.