On-line solid-phase extraction high-performance liquid chromatography- tandem mass spectrometry for the quantitative analysis of tacrolimus in whole blood hemolyzate

Analytical and Bioanalytical Chemistry

Volumn 404, Issue 3, 2012, Pages 863-874

  Neu, Volker ^a,b   Delmotte, Nathanaël ^a,b   Kobold, Uwe ^c   Dülffer, Thomas ^c   Herrmann, Rupert ^c   Von Der Eltz, Herbert ^c   Huber, Christian G ^a  

^a UNIVERSITY OF SALZBURG   (Austria)

^b SAARLAND UNIVERSITY   (Germany)

^c ROCHE DIAGNOSTICS GMBH   (Germany)

Author keywords

Electrospray ionization mass spectrometry; Liquid chromatography; On line solid phase extraction; Tacrolimus; Whole blood analysis

Indexed keywords

ALKALINE PH; ANALYTES; BIOLOGICAL FLUIDS; BLOOD SAMPLES; BLOOD SAMPLING; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; ETHYLENE DIAMINE TETRA-ACETIC ACID; EXTERNAL CALIBRATION; EXTRACTION EFFICIENCIES; IMMUNOSUPPRESSIVE DRUGS; LARGE BIOMOLECULES; LOWER LIMITS OF DETECTIONS; ON-LINE SOLID PHASE EXTRACTION; REACTION MONITORING; RESTRICTED ACCESS MATERIALS; SAMPLE PREPARATION; STATIONARY PHASE; TACROLIMUS; TANDEM MASS SPECTROMETRY; THERAPEUTIC MONITORING; WHOLE BLOOD;

ALKALINITY; CHROMATOGRAPHY; DRUG PRODUCTS; HEMOGLOBIN; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIC LIQUIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

BLOOD;

EDETIC ACID; HEMOGLOBIN; HEPARIN; IMMUNOSUPPRESSIVE AGENT; IONIC LIQUID; TACROLIMUS; TISSUE EXTRACT;

ADSORPTION; ARTICLE; BLOOD; CALIBRATION; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; ERYTHROCYTE; HEMOLYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIMIT OF DETECTION; METHODOLOGY; PH; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

ADSORPTION; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EDETIC ACID; ERYTHROCYTES; HEMOGLOBINS; HEMOLYSIS; HEPARIN; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOSUPPRESSIVE AGENTS; IONIC LIQUIDS; LIMIT OF DETECTION; SOLID PHASE EXTRACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TACROLIMUS; TANDEM MASS SPECTROMETRY; TISSUE EXTRACTS;

EID: 84865530272     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-012-6201-6     Document Type: Article

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