Occurrence of pharmaceuticals and personal care products in German fish tissue: A national study

Environmental Science and Technology

Volumn 46, Issue 16, 2012, Pages 9047-9054

  Subedi, Bikram ^a   Du, Bowen ^a   Chambliss, C Kevin ^a   Koschorreck, Jan ^b   Rüdel, Heinz ^c   Quack, Markus ^d   Brooks, Bryan W ^a   Usenko, Sascha ^a  

^a BAYLOR UNIVERSITY   (United States)

^b UMWELTBUNDESAMT   (Germany)

^c FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

^d UNIVERSITY OF TRIER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANNUAL FLOW; DIPHENHYDRAMINE; FISH TISSUE; FISH TISSUE CONCENTRATIONS; GERMANY; PERSONAL CARE PRODUCTS; PHARMACEUTICALS AND PERSONAL CARE PRODUCTS; SAMPLING LOCATION; SAMPLING SITE; TONALIDE; WASTEWATER TREATMENT PLANTS;

TISSUE;

FISH;

DIPHENHYDRAMINE; DRUG METABOLITE; GALAXOLIDE; NORSERTRALINE; TONALIDE; UNCLASSIFIED DRUG;

CONCENTRATION (COMPOSITION); DRUG; METABOLITE; SAMPLING; SPECIMEN BANK; WASTEWATER; WATER TREATMENT;

ABRAMIS BRAMA; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); FISH; GERMANY; HYGIENE PRODUCT; NONHUMAN; RIVER; UNITED STATES; WASTE WATER TREATMENT PLANT;

ANIMALS; COSMETICS; FISHES; GERMANY; PHARMACEUTICAL PREPARATIONS;

GERMANY; SAAR RIVER;

EID: 84865527146     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es301359t     Document Type: Article

References (51)

1. Daughton, C. G.; Ternes, T. A. Pharmaceuticals and personal care products in the environment: Agents of subtle change? Environ. Health Perspect. 1999, 107, 907-938 (Pubitemid 30068192)
2. Lishman, L.; Smyth, S. A.; Sarafin, K.; Kleywegt, S.; Toito, J.; Peart, T.; Lee, B.; Servos, M.; Beland, M.; Seto, P. Occurrence and reductions of pharmaceuticals and personal care products and estrogens by municipal wastewater treatment plants in Ontario, Canada Sci. Total Environ. 2006, 367 (2-3) 544-558 (Pubitemid 44109889)
3. Simonich, S. L.; Federle, T. W.; Eckhoff, W. S.; Rottiers, A.; Webb, S.; Sabaliunas, D.; De Wolf, W. Removal of fragrance materials during US and European wastewater treatment Environ. Sci. Technol. 2002, 36 (13) 2839-2847 (Pubitemid 34747279)
4. Suarez, S.; Carballa, M.; Omil, F.; Lema, J. M. How are pharmaceuticals and personal care products (PPCPs) removed from urban wastewaters? Rev. Environ. Sci. Biotechnol. 2008, 7, 125-138
5. Daughton, C. G. Environmental stewardship and drugs as pollutants Lancet 2002, 360 (9339) 1035-1036
6. Daughton, C. G. Non-regulated water contaminants: emerging research Environ. Impact Assess. Rev. 2004, 24 (7-8) 711-732 (Pubitemid 39239337)
7. Ankley, G. T.; Brooks, B. W.; Huggett, D. B.; Sumpter, J. P. Repeating history: Pharmaceuticals in the environment Environ. Sci. Technol. 2007, 41 (24) 8211-8217 (Pubitemid 350276421)
8. Kolpin, D. W.; Furlong, E. T.; Meyer, M. T.; Thurman, E. M.; Zaugg, S. D.; Barber, L. B.; Buxton, H. T. Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999-2000: A national reconnaissance Environ. Sci. Technol. 2002, 36 (6) 1202-1211 (Pubitemid 34228893)
9. Gatermann, R.; Biselli, S.; Huhnerfuss, H.; Rimkus, G. G.; Hecker, M.; Karbe, L. Synthetic musks in the environment. Part 1: Species-dependent bioaccumulation of polycyclic and nitro musk fragrances in freshwater fish and mussels Arch. Environ. Contam. Toxicol. 2002, 42 (4) 437-446 (Pubitemid 34454407)
10. Ramirez, A. J.; Brain, R. A.; Usenko, S.; Mottaleb, M. A.; O'Donnell, J. G.; Stahl, L. L.; Wathen, J. B.; Snyder, B. D.; Pitt, J. L.; Perez-Hurtado, P.; Dobbins, L. L.; Brooks, B. W.; Chambliss, C. K. Occurrence of pharmaceuticals and personal care products in fish: Results of a national pilot study in the United States Environ. Toxicol. Chem. 2009, 28 (12) 2587-2597
11. Brooks, B. W.; Chambliss, C. K.; Stanley, J. K.; Ramirez, A.; Banks, K. E.; Johnson, R. D.; Lewis, R. J. Determination of select antidepressants in fish from an effluent-dominated stream Environ. Toxicol. Chem. 2005, 24 (2) 464-469 (Pubitemid 40128355)
12. Nakata, H. Occurrence of synthetic musk fragrances in marine mammals and sharks from Japanese coastal waters Environ. Sci. Technol. 2005, 39 (10) 3430-3434 (Pubitemid 40705461)
13. Brown, J. N.; Paxeus, N.; Forlin, L.; Larsson, D. G. J. Variations in bioconcentration of human pharmaceuticals from sewage effluents into fish blood plasma Environ. Toxicol. Pharm. 2007, 24 (3) 267-274 (Pubitemid 47496033)
14. Ramirez, A. J.; Mottaleb, M. A.; Brooks, B. W.; Chambliss, C. K. Analysis of pharmaceuticals in fish using liquid chromatography-tandem mass spectrometry Anal. Chem. 2007, 79 (8) 3155-3163 (Pubitemid 46640539)
15. Mottaleb, M. A.; Usenko, S.; O'Donnell, J. G.; Ramirez, A. J.; Brooks, B. W.; Chambliss, C. K. Gas chromatography-mass spectrometry screening methods for select UV filters, synthetic musks, alkylphenols, an antimicrobial agent, and an insect repellent in fish J. Chromatogr., A 2009, 1216 (5) 815-823
16. Daughton, C. G.; Brooks, B. W. Active Pharmaceutical Ingredients and Aquatic Organisms. In Environmental Contaminants in Biota: Interpreting Tissue Concentrations, 2 nd ed.; CRC Press/Taylor and Francis: Boca Raton, FL, 2011; p 286-347.
17. Kwon, J. W.; Armbrust, K. L.; Vidal-Dorsch, D.; Bay, S. M.; Xia, K. Determination of 17 alpha-ethynylestradiol, carbamazepine, diazepam, simvastatin, and oxybenzone in fish livers J. AOAC Int. 2009, 92 (1) 359-369
18. Rüdel, H.; Bohmer, W.; Schroter-Kermani, C. Retrospective monitoring of synthetic musk compounds in aquatic biota from German rivers and coastal areas J. Environ. Monit. 2006, 8 (8) 812-823 (Pubitemid 44200390)
19. Wenzel, A.; Bohmer, W.; Muller, J.; Rüdel, H.; Schroeter-Kermani, C. Retrospective monitoring of alkylphenols and alkylphenol monoethoxylates in aquatic biota from 1985 to 2001: Results from the German Environmental Specimen Bank Environ. Sci. Technol. 2004, 38 (6) 1654-1661 (Pubitemid 38364909)
20. Boehmer, W.; Ruedel, H.; Wenzel, A.; Schroeter-Kermani, C. Retrospective monitoring of triclosan and methyl-triclosan in fish: Results from German Environmental Specimen Bank Organohalogen Compd. 2004, 66, 1516-1521
21. Umweltbundesamt. (German Federal Environmental Agency). Umweltprobenbank des Bundes - Umweltprobenbank des Bundes - Verfahrensrichtlinien für Probenahme, Transport, Lagerung und Chemische Charakterisierung von Umwelt- und Human-Organproben; Erich Schmidt Verlag: Berlin, 1996.
22. Klein, R.; Bartel, M.; Paulus, M.; Quack, M.; Tarricone, K.; Teubner, D.; Wagner, G. Umweltprobenbank des Bundes: Guideline for sampling and sample treatment-bream (Abramis brama); V 2.0.1; Biogeography,Trier University: Trier, Germany, 2010; www.umweltprobenbank.de/upb-static/fck/download/SOP-Bream.pdf
23. www.umweltprobenbank.de.
24. Löffler, H. Zur Ökologie des Brachsen (Abramis brama) im Bodensee Schweiz. Z. Hydrol. 1984, 46, 147-161
25. Winfield, I. J.; Townsend, C. R. Factors affecting prey selection by young bream Abramis brama and roach Rutilus rutilus: Insights provided by parallel studies in laboratory and field Environ. Biol. Fish 1988, 21 (4) 279-292 (Pubitemid 19319538)
26. Persson, A.; Bronmark, C. Foraging capacities and effects of competitive release on ontogenetic diet shift in bream, Abramis brama Oikos 2002, 97 (2) 271-281 (Pubitemid 34735656)
27. Weisbrod, A. V.; Woodburn, K. B.; Koelmans, A. A.; Parkerton, T. F.; McElroy, A. E.; Borga, K. Evaluation of bioaccumulation using in vivo laboratory and field studies Integr. Environ. Assess. Manage. 2009, 5, 598-623
28. Subedi, B.; Mottaleb, M. A.; Chambliss, C. K.; Usenko, S. Simultaneous analysis of select pharmaceuticals and personal care products in fish tissue using pressurized liquid extraction combined with silica gel cleanup J. Chromatogr., A 2011, 1218 (37) 6278-6284
29. Du, B.; Perez-Hurtado, P.; Brooks, B. W.; Chambliss, C. K. Evaluation of an isotope dilution liquid chromatography-tandem mass spectrometry method for pharmaceuticals in fish J. Chromatogr., A 2012, http://dx.doi.org/10.1016/j. chroma.2012.07.026
30. Rice, C. P.; Schmitz-Afonso, I.; Loyo-Rosales, J. E.; Link, E.; Thoma, R.; Fay, L.; Altfater, D.; Camp, M. J. Alkylphenol and alkylphenol-ethoxylates in carp, water, and sediment from the Cuyahoga River, Ohio Environ. Sci. Technol. 2003, 37 (17) 3747-3754 (Pubitemid 37074846)
31. Golet, E. M.; Alder, A. C.; Giger, W. Environmental exposure and risk assessment of fluoroquinolone antibacterial agents in wastewater and river water of the Glatt Valley Watershed, Switzerland Environ. Sci. Technol. 2002, 36 (17) 3645-3651 (Pubitemid 35006315)
32. Kock-Schulmeyer, M.; Ginebreda, A.; Postigo, C.; Lopez-Serna, R.; Perez, S.; Brix, R.; Llorca, M.; de Aida, M. L.; Petrovic, M.; Munne, A.; Tirapu, L.; Barcelo, D. Wastewater reuse in Mediterranean semi-arid areas: The impact of discharges of tertiary treated sewage on the load of polar micro pollutants in the Llobregat river (NE Spain) Chemosphere 2011, 82 (5) 670-678
33. Kasprzyk-Hordern, B.; Dinsdale, R. M.; Guwy, A. J. The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters Water Res. 2009, 43 (2) 363-380
34. OSPAR. Mysk Xylene and Other Musks; OSPAR Commision, 2004.
35. Balk, F.; Ford, R. A. Environmental risk assessment for the polycyclic musks AHTN and HHCB in the EU-I. Fate and exposure assessment Toxicol. Lett. 1999, 111 (1-2) 57-79
36. Rimkus, G. G. Polycyclic musk fragrances in the aquatic environment Toxicol. Lett. 1999, 111 (1-2) 37-56
37. Artola-Garicano, E.; Borkent, I.; Damen, K.; Jager, T.; Vaes, W. H. J. Sorption kinetics and microbial biodegradation activity of hydrophobic chemicals in sewage sludge: Model and measurements based on free concentrations Environ. Sci. Technol. 2003, 37 (1) 116-122 (Pubitemid 36043508)
38. Winkler, M.; Kopf, G.; Hauptvogel, C.; Neu, T. Fate of artificial musk fragrances associated with suspended particulate matter (SPM) from the River Elbe (Germany) in comparison to other organic contaminants Chemosphere 1998, 37 (6) 1139-1156 (Pubitemid 28386622)
39. http://www.entsorgungsverband.de/fileadmin/evs-web/images/ Abwasserreinigung/klaeranlagen-broschueren/Brebach.pdf.
40. http://www.saarland.de/dokumente/thema-LUA/ LageberichtKommunalabwasser2002.pdf.
41. Brooks, B. W.; Riley, T. M.; Taylor, R. D. Water quality of effluent-dominated ecosystems: ecotoxicological, hydrological, and management considerations Hydrobiologia 2006, 556, 365-379 (Pubitemid 43004555)
42. Peck, A. M.; Hornbuckle, K. C. Synthetic musk fragrances in urban and rural air of Iowa and the Great Lakes Atmos. Environ. 2006, 40 (32) 6101-6111 (Pubitemid 44302329)
43. Reiner, J. L.; Wong, C. M.; Arcaro, K. F.; Kannan, K. Synthetic musk fragrances in human milk from the United States Environ. Sci. Technol. 2007, 41 (11) 3815-3820 (Pubitemid 46903185)
44. Brooks, B. W.; Huggett, D. B.; Boxall, A. B. A. Pharmaceuticals and personal care products: Research needs for the next decade Environ. Toxicol. Chem. 2009, 28 (12) 2469-2472
45. Fick, J.; Lindberg, R. H.; Parkkonen, J.; Arvidsson, B.; Tysklind, M.; Larsson, D. G. J. Therapeutic levels of levonorgestrel detected in blood plasma of fish: Results from screening rainbow trout exposed to treated sewage effluents Environ. Sci. Technol. 2010, 44 (7) 2661-2666
46. Huggett, D. B.; Cook, J. C.; Ericson, J. F.; Williams, R. T. A theoretical model for utilizing mammalian pharmacology and safety data to prioritize potential impacts of human pharmaceuticals to fish Hum. Ecol. Risk Assess. 2003, 9 (7) 1789-1799 (Pubitemid 38571547)
47. Valenti, T. W.; Gould, G. G.; Berninger, J. P.; Connors, K. A.; Keele, N. B.; Prosser, K. N.; Brooks, B. W. Human therapeutic plasma levels of the selective serotonin reuptake inhibitor (SSRI) sertraline decrease serotonin reuptake transporter binding and shelter-seeking behavior in adult male fathead minnows Environ. Sci. Technol. 2012, 46 (4) 2427-2435
48. Ankley, G. T.; Bennett, R. S.; Erickson, R. J.; Hoff, D. J.; Hornung, M. W.; Johnson, R. D.; Mount, D. R.; Nichols, J. W.; Russom, C. L.; Schmieder, P. K.; Serrrano, J. A.; Tietge, J. E.; Villeneuve, D. L. Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment Environ. Toxicol. Chem. 2010, 29 (3) 730-741
49. Berninger, J. P.; Brooks, B. W. Leveraging mammalian pharmaceutical toxicology and pharmacology data to predict chronic fish responses to pharmaceuticals Toxicol. Lett. 2010, 193 (1) 69-78
50. Brooks, B. W.; Berninger, J. P.; Ramirez, A. J.; Huggett, D. B. Perspectives on Human Pharmaceuticals in the Environment. In Human Pharmaceuticals in the Environment: Current and Future Perspectives; Brooks, B. W.; Huggett, D. B., Eds.; Springer: New York, 2012; pp 1-16.
51. Boxall, A. B. A.; Rudd, M.; Brooks, B. W.; Caldwell, D.; Choi, K.; Hickmann, S.; Innes, E.; Ostapyk, K.; Staveley, J.; Verslycke, T.; Ankley, G. T.; Beazley, K.; Belanger, S.; Berninger, J. P.; Carriquiriborde, P.; Coors, A.; DeLeo, P.; Dyer, S.; Ericson, J. F.; Gagne, F.; Giesy, J. P.; Gouin, T.; Hallstrom, L.; M., K.; Larsson, D. G. J.; Lazorchak, J.; Mastrocco, F.; McLaughlin, A.; McMaster, M.; Meyerhoff, R.; Moore, R.; Parrott, J.; Snape, J.; Murray-Smith, R.; Servos, M.; Sibley, P. K.; Straub, J. O.; Szabo, N.; Tetrault, G.; Topp, E.; Trudeau, V. L.; van Der Kraak, G. Pharmaceuticals and personal care products in the environment: What are the big questions? Environ. Health Perspect. 2012, http://dx.doi.org/10.1016/j.chroma.2012.07.026