Conformationally restricted peptide mimetics by ring-closing olefin metathesis

Synthesis (Germany)

Volumn 44, Issue 17, 2012, Pages 2682-2694

  Wakchaure, Satish ^a   Einsiedel, Jürgen ^a   Waibel, Reiner ^a   Gmeiner, Peter ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

conformational investigations; cyclic olefins; medicinal chemistry; peptide mimetics; ring closing metathesis

Indexed keywords

CONFORMATIONAL INVESTIGATIONS; CYCLIC OLEFINS; MEDICINAL CHEMISTRY; PEPTIDE MIMETICS; RING CLOSING METATHESIS;

CONFORMATIONS; PEPTIDES;

OLEFINS;

2 [6 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO) 3 METHYL 2,5 DIOXO 3,4,5,6,7,10 HEXAHYDRO 1,4 DIAZECIN 1(2H) YL] 3 (4 HYDROXYPHENYL)PROPANOIC ACID; 2 [6 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO) 3 METHYL 2,5 DIOXO 3,4,5,6,7,10 HEXAHYDRO 1,4 DIAZECIN 1(2H) YL] 3 PHENYLPROPANOIC ACID; 2 [6 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO) 3 METHYL 2,5 DIOXO 3,4,5,6,7,10 HEXAHYDRO 1,4 DIAZECIN 1(2H) YL]PROPANOIC ACID; 2 [6 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO) 3,4 DIMETHYL 2,5 DIOXO 3,4,5,6,7,10 HEXAHYDRO 1,4 DIAZECIN 1(2H) YL] 3 PHENYLPROPANOIC ACID; 2 [6 (ACETYLAMINO) 4 METHYL 2,5 DIOXO 3,4,5,6,7,10 HEXAHYDRO 1,4 DIAZECIN 1(2H) YL]ACETIC ACID; [6 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO) 4 METHYL 2,5 DIOXO 3,4,5,6,7,10 HEXAHYDRO 1,4 DIAZECIN 1(2H) YL]ACETIC ACID; ALKENE; PEPTIDOMIMETIC AGENT; TERT BUTYL 2 (ALLYLAMINO)PROPANOIC ACID; TERT BUTYL 2 [6 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO) 3 METHYL 2,5 DIOXO 3,4,5,6,7,10 HEXAHYDRO 1,4 DIAZECIN 1(2H) YL] 3 PHENYLPROPANOIC ACID; TERT BUTYL 2 [6 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO) 3 METHYL 2,5 DIOXO 3,4,5,6,7,10 HEXAHYDRO 1,4 DIAZECIN 1(2H) YL]PROPANOIC ACID; TERT BUTYL 2 [6 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO) 3,4 DIMETHYL 2,5 DIOXO 3,4,5,6,7,10 HEXAHYDRO 1,4 DIAZECIN 1(2H) YL] 3 PHENYLPROPANOIC ACID; TERT BUTYL 2 [[2 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO)PENT 4 ENOYL]AMINO]PROPANOIC ACID; TERT BUTYL 2 [ALLYL [2 (METHYLAMINO)PROPANOYL]AMINO] 3 PHENYLPROPANOIC ACID; TERT BUTYL 2 [ALLYL [2 [2 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO)PENT 4 ENOYLAMINO]PROPANOYL]AMINO] 3 (4 TERT BUTYLOXYPHENYL)PROPANOIC ACID; TERT BUTYL 2 [ALLYL [2 [2 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO)PENT 4 ENOYLAMINO]PROPANOYL]AMINO] 3 PHENYLPROPANOIC ACID; TERT BUTYL 2 [ALLYL [2 [2 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO)PENT 4 ENOYLAMINO]PROPANOYL]AMINO]PROPANOIC ACID; TERT BUTYL 2 [ALLYL [2 [[2 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO)PENT 4 ENOYL]METHYLAMINO]PROPANOYL]AMINO] 3 PHENYLPROPANOIC ACID; TERT BUTYL 2 [N ALLYL 2 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO)PROPANAMIDO] 3 (4 TERT BUTOXYPHENYL)PROPANOIC ACID; TERT BUTYL 2 [N ALLYL 2 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO)PROPANAMIDO] 3 PHENYLPROPANOIC ACID; TERT BUTYL 2 [N ALLYL 2 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO)PROPANAMIDO]PROPANOIC ACID; TERT BUTYL 2 [N ALLYL 2 [(9H FLUOREN 9 YLMETHOXYCARBONYLAMINO)METHYLAMINO]PROPANAMIDO] 3 PHENYLPROPANOIC ACID; TERT BUTYL 3 (4 TERT BUTOXYPHENYL) 2 [6 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO) 3 METHYL 2,5 DIOXO 3,4,5,6,7,10 HEXAHYDRO 1,4 DIAZECIN 1(2H) YL]PROPANOIC ACID; TERT BUTYL [6 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO) 2,5 DIOXO 3,4,5,6,7,10 HEXAHYDRO 1,4 DIAZECIN 1(2H) YL]ACETIC ACID; TERT BUTYL [6 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO) 4 METHYL 2,5 DIOXO 3,4,5,6,7,10 HEXAHYDRO 1,4 DIAZECIN 1(2H) YL]ACETIC ACID; TERT BUTYL [[2 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO)PENT 4 ENOYL]AMINO]ACETIC ACID; TERT BUTYL [[2 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO)PENT 4 ENOYL]METHYLAMINO]ACETIC ACID; TERT BUTYL [ALLYL [[[2 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO)PENT 4 ENOYL]AMINO]ACETYL]AMINO]ACETIC ACID; TERT BUTYL [ALLYL [[[2 (9H FLUOREN 9 YLMETHOXYCARBONYLAMINO)PENT 4 ENOYL]METHYLAMINO]ACETYL]AMINO]ACETIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; PEPTIDE SYNTHESIS; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; RING CLOSING METATHESIS; STRUCTURE ANALYSIS;

EID: 84865525392     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0032-1316758     Document Type: Article

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