Binary system thermodynamics to control pore architecture of PCL scaffold via temperature-driven phase separation process

Journal of Biomaterials Applications

Volumn 27, Issue 3, 2012, Pages 241-254

  Guarino, Vincenzo ^a   Guaccio, Angela ^b   Guarnieri, Daniela ^b   Netti, Paolo A ^b   Ambrosio, Luigi ^a  

^a CNR   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

phase separation; polycaprolactone; porosity; Scaffolds; tissue engineering

Indexed keywords

ANALYTICAL RESULTS; BINARY SYSTEMS; BIOLOGICAL STUDIES; BIOLOGICAL TISSUES; CAPROLACTONE; CELL ACTIVITY; COMPLEX TISSUES; COOLING TEMPERATURE; CRYSTALLINITIES; HIGH POTENTIAL; INTRUSION POROSIMETRY; MACRO SCALE; MACROSTRUCTURES; MICRO-SCALES; PHASE-SEPARATION PROCESS; POLYMER MATRICES; POLYMER PHASIS; PORE ARCHITECTURE; POROUS SCAFFOLD; THERMAL INERTIA; THERMALLY INDUCED PHASE SEPARATION; THERMODYNAMIC FORCES;

ARCHITECTURAL DESIGN; CELL CULTURE; ETHERS; HISTOLOGY; PHASE SEPARATION; POLYCAPROLACTONE; POROSITY; SCAFFOLDS; THERMODYNAMICS; TISSUE; TISSUE ENGINEERING;

SCAFFOLDS (BIOLOGY);

POLYMER; SOLVENT; TISSUE SCAFFOLD;

ARTICLE; CELL CULTURE; CHEMISTRY; SCANNING ELECTRON MICROSCOPY; THERMODYNAMICS;

CELLS, CULTURED; MICROSCOPY, ELECTRON, SCANNING; POLYMERS; SOLVENTS; THERMODYNAMICS; TISSUE SCAFFOLDS;

EID: 84865520252     PISSN: 08853282     EISSN: 15308022     Source Type: Journal    
DOI: 10.1177/0885328211401056     Document Type: Article

References (45)

1. Bonassar LJ, Vacanti CA. Tissue engineering: the first decade and beyond. J Cell Biochem. 1998 ; 72: 297-303
2. Mikos AG, Thorsen AJ, Czerwonka LA, Bao Y, Langer R, Winslow DN, et al. Preparation and characterization of poly(L-lactic acid) foams. Polymer. 1994 ; 35: 1068-1077
3. Yang S, Leong KF, Du Z, Chua CK. The design of scaffolds for use in tissue engineering. Part I. Traditional factors. Tissue Eng. 2001 ; 7: 679-689
4. Ma PX, Zhang R. Microtubular architecture of biodegradable polymer scaffolds. J Biomed Mater Res A. 2001 ; 56: 469-477
5. Aronin CEP, Sadik KW, Lay AL, Rion DB, Tholpady SS, Ogle RC, et al. Comparative effects of scaffold pore size, pore volume, and total void volume on cranial bone healing patterns using microsphere-based scaffolds. J Biomed Mater Res Part A. 2009 ; 89A: 632-641
6. Madden LR, Mortisen DJ, Sussman EM, Dupras SK, Fugate JA, Cuy JL, et al. Proangiogenic scaffolds as functional templates for cardiac tissue engineering. PNAS. 2010 ; 24: 15211-15216
7. Andriano KP, Tabata Y, Ikada Y, Heller J. In vitro and in vivo comparison of bulk and surface hydrolysis in absorbable polymer scaffolds for tissue engineering. J Biomed Mater Res. 1999 ; 48: 602-612
8. Causa F, Netti PA, Ambrosio L. A multi-functional scaffold for tissue regeneration: the need to engineer a tissue analogue. Biomaterials. 2007 ; 28: 5093-5099
9. Harris LD, Kim BS, Mooney DJ. Open pore biodegradable matrices formed with gas foaming. J Biomed Mater Res. 1998 ; 42: 396-402
10. Laurencin CT, Ko FK, Attawia MA, Borden MD. Studies on the development of a tissue engineered matrix for bone regeneration. Cell Mater. 1998 ; 8: 175-181
11. Sachlos E, Czernuszka JT. Making tissue engineering scaffolds work. Review: the application of solid freeform fabrication technology to the production of tissue engineering scaffolds. Eur Cell Mater. 2003 ; 5: 29-40
12. Whang K, Goldstick TK, Healy KE. A biodegradable polymer scaffold for delivery of osteotropic factors. Biomaterials. 2000 ; 21: 2545-2551
13. Karande TS, Ong JL, Agrawal CM. Diffusion in musculoskeletal tissue engineering scaffolds: design issues related to porosity, permeability, architecture, and nutrient mixing. Ann Biomed Eng. 2004 ; 32: 1728-1743
14. Schugens C, Maquet V, Grandfils C, Jerome R, Teyssie P. Polylactide macroporous biodegradable implants for cell transplantation. II. Preparation of polylactide foams by liquid-liquid phase separation. J Biomed Mater Res. 1996 ; 30: 449-461
15. Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials. 2006 ; 27: 3413-3431
16. Guarino V, Ambrosio L. Temperature driven processing techniques for manufacturing fully interconnected porous scaffolds in bone tissue engineering. P I Mech Eng H. 2010 ; 224: 1389-1400
17. Ma PX. Scaffolds for tissue fabrication. Mater today. 2004 ; 7: 30-40
18. Zhang R, Ma PX. Poly(alpha-hydroxyl acids)/hydroxyapatite porous composites for bone-tissue engineering. I. Preparation and morphology. J Biomed Mater Res. 1999 ; 44: 446-455
19. Hou Q, Grijpma DW, Feijen J. Porous polymeric structures for tissue engineering prepared by a coagulation, compression moulding and salt leaching technique. Biomaterials. 2003 ; 24: 1937-1947
20. Hu Y, Grainger DW, Winn SR, Hollinger JO. Fabrication of poly(α-hydroxy acid) foam scaffolds using multiple solvent systems. J Biomed Mater Res. 2002 ; 59: 563-572
21. Russ JC The image processing handbook. Boca Raton, FL: CRC press ; 2006 :
22. Hamedi M, Danner RP. Prediction of solubility parameters using the group-contribution, Lattice-Fluid Theory. J Appl Polym Sci. 2001 ; 80: 197-206
23. Hansen C Hansen solubility parameters: A user's handbook. 2 nd ed. Boca Raton, Fl: CRC Press, 2007. Boca Raton, Fl: CRC Press ; 2007:
24. Sarac A, Ture A, Cankurtaran O, Yilmaz F. Determination of some thermodynamical interaction parameters of polycaprolactone with some solvents by inverse gas chromatography. Polym Int. 2002 ; 51: 1285-1289
25. Perry RH, Green DW Perry's chemical engineers handbook. New York: McGraw-Hill ; 1997:
26. Lorenzi L, Fermeglia M, Torniano GJ. Densities and viscosities 1,1,1-trichloroethane with 13 different solvents at 298.15K. J Chem Eng Data. 1995 ; 40: 1172-1177
27. Grolier JPE, Roux-Desgranges G, Berkane M, Jiménez E, Wilhelm EJ. Heat capacities and densities of mixtures of very polar substances 2.Mixtures containing N,N-dimethylformamide. J Chem Thermodyn. 1993 ; 25: 41-50
28. Van Asten AC, Kok WT, Tijssen R, Poppe H. Study of thermal diffusion of polybutadiene and polytetrahydrofuran in various organic solvents. J Polym Sci Pol Phys. 1996 ; 34: 297-308
29. Zhang HF, Zhao G, Ye H, Ge XS, Cheng SX. An improved hot probe for measuring thermal conductivity of liquids. Meas Sci Technol. 2005 ; 16: 1430-1435
30. Shi G, Cai Q, Wang C, Lu N, Wang S, Bei J. Fabrication and biocompatibility of cell scaffolds of poly(L-lactic acid) and poly(L-lactic-co-glycolic acid). Polym Adv Technol. 2002 ; 13: 227-232
31. Luetzow K, Klein F, Weigel T, Apostel R, Weiss A, Lendlein A. Formation of poly(epsilon-caprolactone) scaffolds loaded with small molecules by integrated processes. J Biomech. 2007 ; 40: 80-88
32. Ho ST, Hutmacher DW. A comparison of micro CT with other techniques used in the characterization of scaffolds. Biomaterials. 2006 ; 27: 1362-1376
33. Grulke EA Polymer handbook. 4 th ed. New York: Wiley, 1999, pp. 675-675. Brandrup EH Immergut EA, ed. New York: Wiley ; 1999: 675-675.
34. Yang F, Qu X, Cui W, Bei J, Yu F, Lu S, et al. Manufacturing and morphology structure of polylactide-type microtubules orientation-structured scaffolds. Biomaterials. 2006 ; 27: 4923-4933
35. Nam YS, Park TG. Porous biodegradable polymeric scaffolds prepared by thermally induced phase separation. J Biomed Mater Res. 1999 ; 47: 8-17
36. Tu C, Cai Q, Yang J, Wan Y, Bei J, Wang S. The fabrication and characterization of poly(lactic acid) scaffolds for tissue engineering by improved solid-liquid phase separation. Polym Adv Technol. 2003 ; 14: 565-573
37. Graham PD, McHugh AJ. Kinetics of thermally induced phase separation in a crystallizable polymer solution. Macromolecules. 1998 ; 31: 2565-2568
38. Huang JC, Lin KT, Deanin RD. Three-dimensional solubility parameters of poly(ε-caprolactone). J Appl Polym Sci. 2006 ; 100: 2002-2009
39. Ma PX, Zhang R, Xiao G, Franceschi R. Engineering new bone tissue in vitro on highly porous poly(alpha-hydroxyl acids)/hydroxyapatite composite scaffolds. J Biomed Mater Res. 2001 ; 54: 284-293
40. Yang F, Qu X, Cui W, Bei J, Yu F, Lu S, et al. Manufacturing and morphology structure of polylactide-type microtubules orientation-structured scaffolds. Biomaterials. 2006 ; 27: 4923-4933
41. Song SW, Torkelson JM. Coarsening effects on microstructure formation in isopycnic polymer solutions and membranes produced via thermally induced phase separation. Macromolecules. 1994 ; 27: 6389-6397
42. Burghardt WR. Phase diagrams for binary polymer systems exhibiting both crystallization and limited liquid-liquid miscibility. Macromolecules. 1989 ; 22: 2482-2486
43. Mandoli C, Mecheri B, Forte G, Pagliari F, Pagliari S, Carotenuto F, et al. Thick soft tissue reconstruction on highly perfusive biodegradable scaffolds. Macromol Biosci. 2010 ; 10: 127-138
44. Schugens C, Maquet V, Grandfils C, Jerome R, Teyssie P. Biodegradable and macroporous polylactide implants for cell transplantation: 1. Preparation of macroporous polylactide supports by solid-liquid phase separation. Polymer. 1996 ; 37: 1027-1038
45. Guarino V, Guaccio A, Netti PA, Ambrosio L. Image processing and fractal box counting: user-assisted method for multi-scale porous scaffold characterization. J Mater Sci Mater Med. 2010 ; 21: 3109-3118