A novel fibrinogenase from Agkistrodon acutus venom protects against DIC via direct degradation of thrombosis and activation of protein C

Biochemical Pharmacology

Volumn 84, Issue 7, 2012, Pages 905-913

  Qi, Jie Zhen ^a   Lin, Xi ^b   Chen, Jia Shu ^a   Huang, Zhen Hua ^a   Qiu, Peng Xin ^a   Yan, Guang Mei ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

Author keywords

DIC; Fibrinogenase; Lipopolysaccharide; Microthrombi; Protein C

Indexed keywords

ANTITHROMBIN III; FIBRINOGEN; FIBRINOGEN DEGRADATION PRODUCT; FIBRINOGENASE 2; FIBRINOLYTIC AGENT; LIPOPOLYSACCHARIDE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN C; SNAKE VENOM; THROMBOPLASTIN; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG; UROKINASE;

AGKISTRODON; AGKISTRODON ACUTUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEGRADATION; DISSEMINATED INTRAVASCULAR CLOTTING; DOWN REGULATION; DRUG MEGADOSE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY INJURY; LIVER INJURY; LOW DRUG DOSE; MICROTHROMBUS; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTHROMBIN TIME; SURVIVAL RATE; THROMBOCYTE COUNT; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION;

AGKISTRODON; ANIMALS; CROTALID VENOMS; DISSEMINATED INTRAVASCULAR COAGULATION; DRUG-INDUCED LIVER INJURY; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; KIDNEY DISEASES; LIPOPOLYSACCHARIDES; MALE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN C; RABBITS; SERINE ENDOPEPTIDASES; THROMBOSIS; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 84865520237     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.06.011     Document Type: Article

References (36)

1. G.M. Vercellotti, N.W. Wickham, K.S. Gustafson, H.Q. Yin, M. Hebert, and H.S. Jacob Thrombin-treated endothelium primes neutrophil functions: inhibition by platelet-activating factor receptor antagonists J Leukoc Biol 45 6 1989 483 490 (Pubitemid 19147354)
2. S.J. Robboy, M.C. Major, R.W. Colman, and J.D. Minna Pathology of disseminated intravascular coagulation (DIC). Analysis of 26 cases Hum Pathol 3 3 1972 327 343
3. F.B. Taylor Jr., C.H. Toh, W.K. Hoots, H. Wada, and M. Levi Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation Thromb Haemost 86 5 2001 1327 1330
4. M. Levi, E. de Jonge, and C.H. ten Disseminated intravascular coagulation Ned Tijdschr Geneeskd 144 10 2000 470 475 (Pubitemid 30136634)
5. M. Levi Disseminated intravascular coagulation: what's new? Crit Care Clin 21 3 2005 449 467 (Pubitemid 40898154)
6. R.N. Rubin, and R.W. Colman Disseminated intravascular coagulation. Approach to treatment Drugs 44 6 1992 963 971 (Pubitemid 23024547)
7. R.M. Hardaway, C.H. Williams, and Y. Sun A new approach to the treatment of experimental septic shock J Surg Res 61 2 1996 311 316 (Pubitemid 26087676)
8. M.G. Vervloet, L.G. Thijs, and C.E. Hack Derangements of coagulation and fibrinolysis in critically ill patients with sepsis and septic shock Semin Thromb Hemost 24 1 1998 33 44 (Pubitemid 28126221)
9. H. Asakura, H. Jokaji, M. Saito, C. Uotani, I. Kumabashiri, and E. Morishita Study of the balance between coagulation and fibrinolysis in disseminated intravascular coagulation using molecular markers Blood Coagul Fibrinolysis 5 5 1994 829 832 (Pubitemid 24366378)
10. K. Ouriel Comparison of safety and efficacy of the various thrombolytic agents Rev Cardiovasc Med 3 Suppl 2 2002 17 24
11. F. Fourrier, M. Jourdain, A. Tournoys, P. Gosset, J. Mangalaboyi, and C. Chopin Effects of a combined antithrombin III and protein C supplementation in porcine acute endotoxic shock Shock 10 5 1998 364 370 (Pubitemid 128463276)
12. D.I. Feinstein Diagnosis and management of disseminated intravascular coagulation: the role of heparin therapy Blood 60 2 1982 284 287 (Pubitemid 12048668)
13. C. Lehmann, T.I. Usichenko, and D. Pavlovic Heparins in sepsis-induced disseminated intravascular coagulation: low weight-high impact? Crit Care Med 33 6 2005 1455 1457 (Pubitemid 40827422)
14. B.D. Freeman, B.A. Zehnbauer, and T.G. Buchman A meta-analysis of controlled trials of anticoagulant therapies in patients with sepsis Shock 20 1 2003 5 9
15. K. Shimamura, K. Oka, M. Nakazawa, and M. Kojima Distribution patterns of microthrombi in disseminated intravascular coagulation Arch Pathol Lab Med 107 10 1983 543 547 (Pubitemid 13008611)
16. W.P. Fay, N. Garg, and M. Sunkar Vascular functions of the plasminogen activation system Arterioscler Thromb Vasc Biol 27 6 2007 1231 1237 (Pubitemid 46809410)
17. N.J. de Fouw, Y.F. de Jong, F. Haverkate, and R.M. Bertina Activated protein C increases fibrin clot lysis by neutralization of plasminogen activator inhibitor - no evidence for a cofactor role of protein S Thromb Haemost 60 2 1988 328 333
18. L. Xiuxia, C. Jiashu, Z. Yingna, Q. Pengxin, and Y. Guangmei Purification and biochemical characterization of F II(a), a fibrinolytic enzyme from Agkistrodon acutus venom Toxicon 39 8 2001 1133 1139 (Pubitemid 32295880)
19. J. Hermida, R. Montes, J.A. Paramo, and E. Rocha Endotoxin-induced disseminated intravascular coagulation in rabbits: effect of recombinant hirudin on hemostatic parameters, fibrin deposits, and mortality J Lab Clin Med 131 1 1998 77 83 (Pubitemid 28065771)
20. X. Lin, X.X. Liang, J.S. Chen, Q. Chen, P.X. Qiu, and G.M. Yan The effect of fibrinolytic enzyme FIIa from Agkistrodon acutus venom on disseminated intravascular coagulation in rabbits Transl Res 150 5 2007 295 302 (Pubitemid 47615636)
21. E.A. Jaffe, R.L. Nachman, C.G. Becker, and C.R. Minick Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria J Clin Invest 52 11 1973 2745 2756
22. Y.A. Elsayed, K. Nakagawa, K. Ichikawa, S. Ohkawara, and K. Sueishi Expression of tissue factor and interleukin-1 beta in a novel rabbit model of disseminated intravascular coagulation induced by carrageenan and lipopolysaccharide Pathobiology 63 6 1995 328 340 (Pubitemid 26138964)
23. M. Levi, C.H. ten, T. van der Poll, and S.J. van Deventer Pathogenesis of disseminated intravascular coagulation in sepsis JAMA 270 8 1993 975 979 (Pubitemid 23244737)
24. Y. Liu, C. Wang, Y. Yang, X. Hou, and J. Wang Pro-urokinase up-regulates the expression of urokinase-type plasminogen activator (u-PA) in human pulmonary arterial endothelial cells Thromb Res 121 4 2008 485 491 (Pubitemid 351174271)
25. F.B. Taylor Jr., G.T. Peer, M.S. Lockhart, G. Ferrell, and C.T. Esmon Endothelial cell protein C receptor plays an important role in protein C activation in vivo Blood 97 6 2001 1685 1688 (Pubitemid 32217234)
26. R.A. Marlar, J. Endres-Brooks, and C. Miller Serial studies of protein C and its plasma inhibitor in patients with disseminated intravascular coagulation Blood 66 1 1985 59 63 (Pubitemid 15004784)
27. P.S. Gable, D.T. Le, W. McGehee, and S.I. Rapaport A protac-based screening test for activated protein C-resistant factor Va and other defects of the protein C anticoagulant pathway Blood Coagul Fibrinolysis 8 6 1997 327 335 (Pubitemid 27428530)
28. M.M. Kowalik, T. Smiatacz, M. Hlebowicz, R. Pajuro, N. Dziarmaga-Piasecka, and M. Gesing Occurrence of disseminated intravascular coagulation in purulent meningitis and influence on mortality in 118 patients Przegl Epidemiol 60 2 2006 281 289
29. T.A. Warr, L.V. Rao, and S.I. Rapaport Disseminated intravascular coagulation in rabbits induced by administration of endotoxin or tissue factor: effect of anti-tissue factor antibodies and measurement of plasma extrinsic pathway inhibitor activity Blood 75 7 1990 1481 1489 (Pubitemid 20114888)
30. F.J. Walker, and P.J. Fay Regulation of blood coagulation by the protein C system FASEB J 6 8 1992 2561 2567
31. E.F. Mammen Antithrombin: its physiological importance and role in DIC Semin Thromb Hemost 24 1 1998 19 25 (Pubitemid 28126219)
32. L.V. Rao, S.I. Rapaport, and A.D. Hoang Binding of factor VIIa to tissue factor permits rapid antithrombin III/heparin inhibition of factor VIIa Blood 81 10 1993 2600 2607 (Pubitemid 23147563)
33. L.V. Rao, O. Nordfang, A.D. Hoang, and U.R. Pendurthi Mechanism of antithrombin III inhibition of factor VIIa/tissue factor activity on cell surfaces. Comparison with tissue factor pathway inhibitor/factor Xa-induced inhibition of factor VIIa/tissue factor activity Blood 85 1 1995 121 129
34. Q.Q. Wang, J.S. Chen, X.X. Liang, P.X. Qiu, Y.W. Wang, and G.M. Yan Hemorrhagic activity and mechanism of FIIa, a fibrinolytic enzyme from Agkistrodon acutus venom Acta Pharmacol Sin 25 4 2004 514 521
35. M. Nguyen, J. Arkell, and C.J. Jackson Activated protein C directly activates human endothelial gelatinase A J Biol Chem 275 13 2000 9095 9098 (Pubitemid 30185120)
36. F.B. Taylor Jr., A. Chang, C.T. Esmon, A. D'Angelo, S. Vigano-D'Angelo, and K.E. Blick Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon J Clin Invest 79 3 1987 918 925 (Pubitemid 17050920)