Fifty shades of brown: Perivascular fat, thermogenesis, and atherosclerosis

Circulation

Volumn 126, Issue 9, 2012, Pages 1012-1015

  Kiefer, Florian W ^a,b   Cohen, Paul ^a,b,c   Plutzky, Jorge ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REACTIVE OXYGEN METABOLITE;

ADIPOGENESIS; ADIPOSE TISSUE; ATHEROSCLEROSIS; BROWN ADIPOSE TISSUE; ENERGY EXPENDITURE; HUMAN; NONHUMAN; PERIVASCULAR ADIPOSE TISSUE; PRIORITY JOURNAL; REVIEW; SMOOTH MUSCLE FIBER; THERMOGENESIS; VASCULAR SMOOTH MUSCLE; VASCULARIZATION;

ADIPOSE TISSUE; ANIMALS; ATHEROSCLEROSIS; BODY TEMPERATURE REGULATION; MUSCLE, SMOOTH, VASCULAR; PPAR GAMMA;

EID: 84865515226     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.112.123521     Document Type: Review

References (22)

1. Iozzo P Myocardial, perivascular, and epicardial fat. Diabetes Care. 2011;34 (Suppl 2):S371-S379.
2. Britton KA, Fox CS Perivascular adipose tissue and vascular disease. Clin Lipidol. 2011;6:79-91.
3. Lehman SJ, Massaro JM, Schlett CL, O'Donnell CJ, Hoffmann U, Fox CS Peri-aortic fat, cardiovascular disease risk factors, and aortic calcification: the Framingham Heart Study. Atherosclerosis. 2010;210: 656-661.
4. Soltis EE, Cassis LA Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness. Clin Exp Hypertens A 1991;13: 277-296.
5. Lohn M, Dubrovska G, Lauterbach B, Luft FC, Gollasch M, Sharma AM Periadventitial fat releases a vascular relaxing factor. FASEB J 2002;16: 1057-1063. (Pubitemid 34753512)
6. Greenstein AS, Khavandi K, Withers SB, Sonoyama K, Clancy O, Jeziorska M, Laing I, Yates AP, Pemberton PW, Malik RA, Heagerty AM Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation. 2009; 119:1661-1670.
7. Chang L, Villacorta L, Li R, Hamblin M, Xu W, Dou C, Zhang J, Wu J, Zeng R, Chen E Loss of perivascular adipose tissue on peroxisome proliferator- activated receptor-2277; deletion in smooth muscle cells impairs intravascular thermoregulation and enhances atherosclerosis. Circulation. 2012;126:1067-1078.
8. Sigmund CD Endothelial and vascular muscle PPARgamma in arterial pressure regulation: lessons from genetic interference and deficiency. Hypertension. 55:437-444.
9. Fitzgibbons TP, Kogan S, Aouadi M, Hendricks GM, Straubhaar J, Czech MP Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation. Am J Physiol Heart Circ Physiol. 2011;301:H1425-H1437.
10. Hotamisligil GS Inflammation and metabolic disorders. Nature. 2006; 444:860-867. (Pubitemid 46024993)
11. Berg AH, Scherer PE Adipose tissue, inflammation, and cardiovascular disease. Circ Res. 2005;96:939-949. (Pubitemid 40712793)
12. Cannon B, Nedergaard J Brown adipose tissue: function and physiological significance. Physiol Rev. 2004;84:277-359. (Pubitemid 38054374)
13. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JM, Kemerink GJ, Bouvy ND, Schrauwen P, Teule GJ Cold-activated brown adipose tissue in healthy men. N Engl J Med. 2009;360: 1500-1508.
14. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009;360:1509-1517.
15. Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerback S, Nuutila P Functional brown adipose tissue in healthy adults. N Engl J Med. 2009;360: 1518-1525.
16. Wu J, Bostrom P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerback S, Schrauwen P, Spiegelman BM Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell. 2012;150:366-376.
17. Ouellet V, Labbe SM, Blondin DP, Phoenix S, Guerin B, Haman F, Turcotte EE, Richard D, Carpentier AC Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest. 2012;122:545-552.
18. Cypess AM, Chen YC, Sze C, Wang K, English J, Chan O, Holman AR, Tal I, Palmer MR, Kolodny GM, Kahn CR Cold but not sympathomimetics activates human brown adipose tissue in vivo. Proc Natl Acad Sci U S A 2012;109:10001-10005.
19. Langin D Recruitment of brown fat and conversion of white into brown adipocytes: strategies to fight the metabolic complications of obesity? Biochim Biophys Acta. 2010;1801:372-376.
20. Kiefer FW, Vernochet C, O'Brien P, Spoerl S, Brown JD, Nallamshetty S, Zeyda M, Stulnig TM, Cohen DE, Kahn CR, Plutzky J Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue. Nat Med. 2012. May 6. doi: 10.1038/nm.2757. [Epub ahead of print].
21. Kortelainen ML Association between cardiac pathology and fat tissue distribution in an autopsy series of men without premortem evidence of cardiovascular disease. Int J Obes Relat Metab Disord. 1996;20:245-252
22. Bartelt A, Bruns OT, Reimer R, Hohenberg H, Ittrich H, Peldschus K, Kaul MG, Tromsdorf UI, Weller H, Waurisch C, Eychmuller A, Gordts PL, Rinninger F, Bruegelmann K, Freund B, Nielsen P, Merkel M, Heeren J Brown adipose tissue activity controls triglyceride clearance. Nat Med. 2011;17:200-205.