Multilayered mucoadhesive hydrogel films based on thiolated hyaluronic acid and polyvinylalcohol for insulin delivery

Acta Biomaterialia

Volumn 8, Issue 10, 2012, Pages 3643-3651

  Ding, J ^a   He, R ^a   Zhou, G ^b   Tang, C ^a   Yin, C ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Hyaluronic acid cysteamine; Mucosal adhesion; Multilayered hydrogel film; Polyvinylalcohol; Unidirectional release

Indexed keywords

BIOACTIVITY; CONTROLLED DRUG DELIVERY; FILM PREPARATION; HYDROGELS; INSULIN; ORGANIC ACIDS; SCANNING ELECTRON MICROSCOPY; TARGETED DRUG DELIVERY;

BACKING LAYERS; CYSTEAMINE; HYALURONIC ACID-CYSTEAMINE; HYDROGEL FILMS; MUCOADHESIVES; MUCOSAL ADHESIONS; MULTI-LAYERED; MULTILAYERED HYDROGEL FILM; POLYVINYLALCOHOL; UNIDIRECTIONAL RELEASE;

HYALURONIC ACID;

DISULFIDE; GLUCOSE; GLUTARALDEHYDE; HYALURONIC ACID; INSULIN; MERCAPTAMINE; POLYVINYL ALCOHOL; THIOL; THIOLATED HYALURONIC ACID; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CHEMICAL COMPOSITION; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CROSS LINKING; DRUG ACTIVITY; DRUG CONFORMATION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG PENETRATION; DRUG STABILITY; GLUCOSE BLOOD LEVEL; HYDROGEL; MACROMOLECULE; MALE; MUCOADHESION; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SCANNING ELECTRON MICROSCOPY; VACUUM; WETTABILITY;

EID: 84865507124     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2012.06.027     Document Type: Article

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