Adrenergic-pathway gene variants influence beta-blockerrelated outcomes after acute coronary syndrome in a race-specific manner

Journal of the American College of Cardiology

Volumn 60, Issue 10, 2012, Pages 898-907

  Cresci, Sharon ^a   Dorn, Gerald W ^a   Jones, Philip G ^b   Beitelshees, Amber L ^c   Li, Allie Y ^a   Lenzini, Petra A ^a   Province, Michael A ^a   Spertus, John A ^b   Lanfear, David E ^d  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d HENRY FORD HOSPITAL   (United States)

Author keywords

blocker therapy; pharmacogenetics; racial disparities.

Indexed keywords

ALPHA 2C ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT;

ACUTE CORONARY SYNDROME; ACUTE HEART INFARCTION; ADRENERGIC SYSTEM; ADULT; AFRICAN AMERICAN; ALLELE; ALPHA 2C ADRENERGIC RECEPTOR GENE; ARTICLE; BETA 1 ADRENERGIC RECEPTOR GENE; BETA 2 ADRENERGIC RECEPTOR GENE; CAUCASIAN; COHORT ANALYSIS; FEMALE; G PROTEIN RECEPTOR KINASE 5 GENE; GENE; GENE DELETION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; RACE DIFFERENCE; SURVIVAL; UNSTABLE ANGINA PECTORIS;

ACUTE CORONARY SYNDROME; ADRENERGIC BETA-ANTAGONISTS; ADULT; AFRICAN AMERICANS; AGED; ANGINA, UNSTABLE; COHORT STUDIES; CONFOUNDING FACTORS (EPIDEMIOLOGY); EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; G-PROTEIN-COUPLED RECEPTOR KINASE 5; GENE DELETION; HOMOZYGOTE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MUTAGENESIS, INSERTIONAL; MYOCARDIAL INFARCTION; POLYMORPHISM, GENETIC; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; RESEARCH DESIGN; SIGNAL TRANSDUCTION; UNITED STATES;

EID: 84865502728     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2012.02.051     Document Type: Article

References (40)

1. D. Lloyd-Jones, R.J. Adams, T.M. Brown Heart disease and stroke statistics2010 update: a report from the American Heart Association Circulation 121 2010 e46 e215
2. E. Braunwald, E.M. Antman, J.W. Beasley ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Unstable Angina) J Am Coll Cardiol 36 2000 970 1062
3. E.M. Antman, M. Hand, P.W. Armstrong Canadian Cardiovascular Society; American Academy of Family Physicians; American College of Cardiology; American Heart Association 2007 focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines J Am Coll Cardiol 51 2008 210 247
4. H.M. Krumholz, J.L. Anderson, B.L. Bachelder ACC/AHA 2008 performance measures for adults with ST-elevation and non-ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures (Writing Committee to Develop Performance Measures for ST-Elevation and Non-ST-Elevation Myocardial Infarction) J Am Coll Cardiol 52 2008 2046 2099
5. Z.M. Chen, H.C. Pan, Y.P. Chen Early intravenous then oral metoprolol in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial Lancet 366 2005 1622 1632
6. N. Freemantle, J. Cleland, P. Young, J. Mason, J. Harrison Beta blockade after myocardial infarction: systematic review and meta regression analysis BMJ 318 1999 1730 1737
7. C.R. Asher, D.J. Moliterno, M.V. Bhapkar Association of race with complications and prognosis following acute coronary syndromes Am J Cardiol 94 2004 792 794
8. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF) Lancet 353 1999 2001 2007
9. The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial Lancet 353 1999 9 13
10. M. Packer, M.R. Bristow, J.N. Cohn U.S. Carvedilol Heart Failure Study Group The effect of carvedilol on morbidity and mortality in patients with chronic heart failure N Engl J Med 334 1996 1349 1355
11. C.W. Yancy Heart failure in African Americans: a cardiovascular engima J Card Fail 6 2000 183 186
12. C.W. Yancy Heart failure in African Americans Am J Cardiol 96 2005 3i 12i
13. S. Cresci, R.J. Kelly, T.P. Cappola Clinical and genetic modifiers of long-term survival in heart failure J Am Coll Cardiol 54 2009 432 444
14. S.B. Liggett, J. Mialet-Perez, S. Thaneemit-Chen A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure Proc Natl Acad Sci U S A 103 2006 11288 11293
15. S.B. Liggett, S. Cresci, R.J. Kelly A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure Nat Med 14 2008 510 517
16. M.R. Bristow Beta-adrenergic receptor blockade in chronic heart failure Circulation 101 2000 558 569
17. J. Shin, M.T. Lobmeyer, Y. Gong Relation of beta(2)-adrenoceptor haplotype to risk of death and heart transplantation in patients with heart failure Am J Cardiol 99 2007 250 255
18. M.R. Bristow, G.A. Murphy, H. Krause-Steinrauf An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure Circ Heart Fail 3 2010 21 28
19. D.E. Lanfear, P.G. Jones, S. Marsh, S. Cresci, H.L. McLeod, J.A. Spertus Beta2-adrenergic receptor genotype and survival among patients receiving beta-blocker therapy after an acute coronary syndrome JAMA 294 2005 1526 1533
20. J. Spertus, D. Safley, M. Garg, P. Jones, E.D. Peterson The influence of race on health status outcomes one year after an acute coronary syndrome J Am Coll Cardiol 46 2005 1838 1844
21. T.M. Morgan, H.M. Krumholz, R.P. Lifton, J.A. Spertus Nonvalidation of reported genetic risk factors for acute coronary syndrome in a large-scale replication study JAMA 297 2007 1551 1561
22. J.A. Spertus, E. Peterson, J.S. Rumsfeld, P.G. Jones, C. Decker, H. Krumholz The Prospective Registry Evaluating Myocardial Infarction: Events and Recovery (PREMIER)evaluating the impact of myocardial infarction on patient outcomes Am Heart J 151 2006 589 597
23. E. Braunwald Unstable angina A classification Circulation 80 1989 410 414
24. D.E. Lanfear, P.G. Jones, S. Cresci, F. Tang, S.S. Rathore, J.A. Spertus Factors influencing patient willingness to participate in genetic research after a myocardial infarction Genome Med 3 2011 39
25. S. Rozen, H. Skaletsky Primer3 on the WWW for general users and for biologist programmers Methods Mol Biol 132 2000 365 386
26. S. Marsh, C.R. King, A.A. Garsa, H.L. McLeod Pyrosequencing of clinically relevant polymorphisms Methods Mol Biol 311 2005 97 114
27. H.E. Collins-Schramm, C.M. Phillips, D.J. Operario Ethnic-difference markers for use in mapping by admixture linkage disequilibrium Am J Hum Genet 70 2002 737 750
28. S. Cresci, J. Wu, M.A. Province Peroxisome proliferator-activated receptor pathway gene polymorphism associated with extent of coronary artery disease in patients with type 2 diabetes in the Bypass Angioplasty Revascularization Investigation 2 Diabetes Trial Circulation 124 2011 1426 1434
29. J.L. Fleiss, B.A. Levin, M.C. Paik Statistical Methods for Rates and Proportions 3rd edition 2003 J. Wiley Hoboken, NJ
30. R Development Core Team A language and environment for statistical computing R Foundation for Statistical Computing http://www.r-project.org/index. html 2008 Accessed August 2012
31. D.E. Lanfear, S. Marsh, S. Cresci, J.A. Spertus, H.L. McLeod Frequency of compound genotypes associated with beta-blocker efficacy in congestive heart failure Pharmacogenomics 5 2004 553 558
32. H.M. Krumholz, J.L. Anderson, N.H. Brooks ACC/AHA clinical performance measures for adults with ST-elevation and non-ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures (Writing Committee to Develop Performance Measures on ST-Elevation and Non-ST-Elevation Myocardial Infarction) J Am Coll Cardiol 47 2006 236 265
33. J.A. Spertus, K.A. Eagle, H.M. Krumholz, K.R. Mitchell, S.L. Normand American College of Cardiology and American Heart Association methodology for the selection and creation of performance measures for quantifying the quality of cardiovascular care J Am Coll Cardiol 45 2005 1147 1156
34. C.P. Cannon, A. Battler, R.G. Brindis American College of Cardiology key data elements and definitions for measuring the clinical management and outcomes of patients with acute coronary syndromes A report of the American College of Cardiology Task Force on Clinical Data Standards (Acute Coronary Syndromes Writing Committee) J Am Coll Cardiol 38 2001 2114 2130
35. K.M. Small, L.E. Wagoner, A.M. Levin, S.L. Kardia, S.B. Liggett Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure N Engl J Med 347 2002 1135 1142
36. M.C. Gerson, L.E. Wagoner, N. McGuire, S.B. Liggett Activity of the uptake-1 norepinephrine transporter as measured by I-123 MIBG in heart failure patients with a loss-of-function polymorphism of the presynaptic alpha2C-adrenergic receptor J Nucl Cardiol 10 2003 583 589
37. M.T. Lobmeyer, Y. Gong, S.G. Terra Synergistic polymorphisms of beta1 and alpha2C-adrenergic receptors and the influence on left ventricular ejection fraction response to beta-blocker therapy in heart failure Pharmacogenet Genomics 17 2007 277 282
38. M.R. Bristow, H. Krause-Steinrauf, R. Nuzzo Effect of baseline or changes in adrenergic activity on clinical outcomes in the beta-blocker evaluation of survival trial Circulation 110 2004 1437 1442
39. T.A. Kohout, R.J. Lefkowitz Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization Mol Pharmacol 63 2003 9 18
40. J.B. Muhlestein, B.D. Horne, T.L. Bair Usefulness of in-hospital prescription of statin agents after angiographic diagnosis of coronary artery disease in improving continued compliance and reduced mortality Am J Cardiol 87 2001 257 261