CXCL5, a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer

European Journal of Cancer

Volumn 48, Issue 14, 2012, Pages 2244-2251

  Kawamura, Mikio ^a   Toiyama, Yuji ^a   Tanaka, Kouji ^a   Saigusa, Susumu ^a   Okugawa, Yoshinaga ^a   Hiro, Junichiro ^a   Uchida, Keiichi ^a   Mohri, Yasuhiko ^a   Inoue, Yasuhiro ^a   Kusunoki, Masato ^a  

^a MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Colorectal cancer; CXCL5; Liver metastasis; Prognostic marker

Indexed keywords

CHEMOKINE RECEPTOR CXCR2; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER PROGNOSIS; CANCER SURVIVAL; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CLINICAL FEATURE; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIVER METASTASIS; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, NEUTRALIZING; CACO-2 CELLS; CASE-CONTROL STUDIES; CELL MOVEMENT; CELL PROLIFERATION; CHEMOKINE CXCL5; CHI-SQUARE DISTRIBUTION; CHILD; COLORECTAL NEOPLASMS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HT29 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; JAPAN; KAPLAN-MEIER ESTIMATE; LIVER NEOPLASMS; LOGISTIC MODELS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM INVASIVENESS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RECEPTORS, INTERLEUKIN-8B; RECOMBINANT PROTEINS; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION; YOUNG ADULT;

EID: 84865502454     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2011.11.032     Document Type: Article

References (34)

1. A. Jemal, R. Siegel, J. Xu, and E. Ward Cancer statistics, 2010 CA Cancer J Clin 60 2010 277 300
2. A.F. Chambers, A.C. Groom, and I.C. MacDonald Dissemination and growth of cancer cells in metastatic sites Nat Rev Cancer 2 2002 563 572
3. G.L. Nicolson Molecular mechanisms of cancer metastasis: tumor and host properties and the role of oncogenes and suppressor genes Curr Opin Oncol 3 1991 75 92
4. A.D. Luster Chemokines-chemotactic cytokines that mediate inflammation N Engl J Med 338 1998 436 445
5. A. Muller, B. Homey, and H. Soto Involvement of chemokine receptors in breast cancer metastasis Nature 410 2001 50 56
6. F. Balkwill Cancer and the chemokine network Nat Rev Cancer 4 2004 540 550
7. B. Wang, L.M. Khachigian, and L. Esau A key role for early growth response-1 and nuclear factor-kappaB in mediating and maintaining GRO/CXCR2 proliferative signaling in esophageal cancer Mol Cancer Res 7 2009 755 764
8. S. Singh, R. Singh, and P.K. Sharma Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion Cancer Lett 283 2009 29 35
9. D.A. Arenberg, M.P. Keane, and B. DiGiovine Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer J Clin Invest 102 1998 465 472
10. S. Keates, A.C. Keates, E. Mizoguchi, A. Bhan, and C.P. Kelly Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis Am J Physiol 273 1997 G75 G82
11. J. Vandercappellen, J. Van Damme, and S. Struyf The role of CXC chemokines and their receptors in cancer Cancer Lett 267 2008 226 244
12. L.A. Begley, S. Kasina, and R. Mehra CXCL5 promotes prostate cancer progression Neoplasia 10 2008 244 254
13. M.N. Wente, M.P. Keane, and M.D. Burdick Blockade of the chemokine receptor CXCR2 inhibits pancreatic cancer cell-induced angiogenesis Cancer Lett 241 2006 221 227
14. J.Y. Park, K.H. Park, and S. Bang CXCL5 overexpression is associated with late stage gastric cancer J Cancer Res Clin Oncol 133 2007 835 840
15. S. Saigusa, Y. Toiyama, and K. Tanaka Stromal CXCR4 and CXCL12 expression is associated with distant recurrence and poor prognosis in rectal cancer after chemoradiotherapy Ann Surg Oncol 17 2010 2051 2058
16. Y. Toiyama, Y. Inoue, and H. Yasuda DPEP1, expressed in the early stages of colon carcinogenesis, affects cancer cell invasiveness J Gastroenterol 46 2011 153 163
17. F.M. Speetjens, P.J. Kuppen, and M.H. Sandel Disrupted expression of CXCL5 in colorectal cancer is associated with rapid tumor formation in rats and poor prognosis in patients Clin Cancer Res 14 2008 2276 2284
18. C. Rubie, V.O. Frick, and M. Wagner ELR+ CXC chemokine expression in benign, malignant colorectal conditions BMC Cancer 8 2008 178
19. J. Dimberg, O. Dienus, S. Lofgren, A. Hugander, and D. Wagsater Expression and gene polymorphisms of the chemokine CXCL5 in colorectal cancer patients Int J Oncol 31 2007 97 102
20. S. Hojo, K. Koizumi, and K. Tsuneyama High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer Cancer Res 67 2007 4725 4731
21. H. Musha, H. Ohtani, and T. Mizoi Selective infiltration of CCR5(+)CXCR3(+) T lymphocytes in human colorectal carcinoma Int J Cancer 116 2005 949 956
22. N. Kanagawa, M. Niwa, and Y. Hatanaka CC-chemokine ligand 17 gene therapy induces tumor regression through augmentation of tumor-infiltrating immune cells in a murine model of preexisting CT26 colon carcinoma Int J Cancer 121 2007 2013 2022
23. C.C. Schimanski, S. Schwald, and N. Simiantonaki Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer Clin Cancer Res 11 2005 1743 1750
24. P. Ghadjar, S.E. Coupland, and I.K. Na Chemokine receptor CCR6 expression level and liver metastases in colorectal cancer J Clin Oncol 24 2006 1910 1916
25. A. Zipin-Roitman, T. Meshel, and O. Sagi-Assif CXCL10 promotes invasion-related properties in human colorectal carcinoma cells Cancer Res 67 2007 3396 3405
26. J. Kim, T. Mori, and S.L. Chen Chemokine receptor CXCR4 expression in patients with melanoma and colorectal cancer liver metastases and the association with disease outcome Ann Surg 244 2006 113 120
27. K. Gunther, J. Leier, and G. Henning Prediction of lymph node metastasis in colorectal carcinoma by expression of chemokine receptor CCR7 Int J Cancer 116 2005 726 733
28. J. Li, R. Sun, K. Tao, and G. Wang The CCL21/CCR7 pathway plays a key role in human colon cancer metastasis through regulation of matrix metalloproteinase-9 Dig Liver Dis 43 2011 40 47
29. F. Tacke, H.W. Zimmermann, C. Trautwein, and B. Schnabl CXCL5 plasma levels decrease in patients with chronic liver disease J Gastroenterol Hepatol 26 2011 523 529
30. B. Cambien, B.F. Karimdjee, and P. Richard-Fiardo Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonism Br J Cancer 100 2009 1755 1764
31. F. Marchesi, L. Piemonti, and G. Fedele The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma Cancer Res 68 2008 9060 9069
32. A.J. Minn, G.P. Gupta, and P.M. Siegel Genes that mediate breast cancer metastasis to lung Nature 436 2005 518 524
33. C.K. Goldman, R.L. Kendall, and G. Cabrera Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate Proc Natl Acad Sci U S A 95 1998 8795 8800
34. S. Rose-John, and P.C. Heinrich Soluble receptors for cytokines and growth factors: generation and biological function Biochem J 300 Pt. 2 1994 281 290