High insulin-like growth factor mRNA-binding protein 3 (IMP3) protein expression is associated with poor survival in muscle-invasive bladder cancer

BJU International

Volumn 110, Issue 6B, 2012, Pages

  Szarvas, Tibor ^a,b   Dorp, Frank Vom ^a   Niedworok, Christian ^a,c   Melchior Becker, Ariane ^c   Fischer, Jens W ^c   Singer, Bernhard B ^a   Reis, Henning ^a   Bánkfalvi, Ágnes ^a   Schmid, Kurt W ^a   Romics, Imre ^d   Ergün, Süleyman ^a   Rübben, Herbert ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^d SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

bladder cancer; CD44; IGF2; IGF2BP3; IMP3; KOC1; prognosis

Indexed keywords

HERMES ANTIGEN; INSULIN LIKE GROWTH FACTOR MRNA BINDING PROTEIN 3; MESSENGER RNA; RNA BINDING PROTEIN; SOMATOMEDIN B; SOMATOMEDIN B RECEPTOR; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BLADDER CANCER; CANCER GRADING; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CONFIDENCE INTERVAL; CORRELATION ANALYSIS; DISEASE FREE SURVIVAL; FEMALE; FOLLOW UP; GENE; GENE EXPRESSION; HAZARD RATIO; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMP3 GENE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; MUSCLE INVASIVE BLADDER CANCER; OVERALL SURVIVAL; PREDICTION; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; PROTEIN EXPRESSION; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; UNIVARIATE ANALYSIS; WESTERN BLOTTING;

AGED; CELLS, CULTURED; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; MALE; MIDDLE AGED; MUSCLE, SMOOTH; NEOPLASM INVASIVENESS; RNA, MESSENGER; SURVIVAL RATE; URINARY BLADDER NEOPLASMS;

EID: 84865501117     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2012.11149.x     Document Type: Article

References (19)

1. Stein JP, Skinner DG,. Radical cystectomy for invasive bladder cancer: long-term results of a standard procedure. World J Urol 2006; 24: 296-304 (Pubitemid 44143761)
2. Müeller-Pillasch F, Lacher U, Wallrapp C, et al,. Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein. Oncogene 1997; 14: 2729-33 (Pubitemid 27283112)
3. Wang T, Hopkins D, Schmidt C, et al,. Identification of genes differentially over-expressed in lung squamous cell carcinoma using combination of cDNA subtraction and microarray analysis. Oncogene 2000; 19: 1519-28 (Pubitemid 30175673)
4. Mueller F, Bommer M, Lacher U, et al,. KOC is a novel molecular indicator of malignancy. Br J Cancer 2003; 88: 699-701 (Pubitemid 36411447)
5. Hanley KZ, Facik MS, Bourne PA, et al,. Utility of anti-L523S antibody in the diagnosis of benign and malignant serous effusions. Cancer 2008; 114: 49-56 (Pubitemid 351304612)
6. Ikeda K, Tate G, Suzuki T, Kitamura T, Mitsuya T,. IMP3/L523S, a novel immunocytochemical marker that distinguishes benign and malignant cells: the expression profiles of IMP3/L523S in effusion cytology. Hum Pathol 2010; 41: 745-50
7. Li L, Xu H, Spaulding BO, et al,. Expression of RNA-binding protein IMP3 (KOC) in benign urothelium and urothelial tumors. Hum Pathol 2008; 39: 1205-11
8. Jiang Z, Chu PG, Woda BA, et al,. Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study. Lancet Oncol 2006; 7: 556-64 (Pubitemid 43923666)
9. Li S, Cha J, Kim J, et al,. Insulin-like growth factor II mRNA-binding protein 3: a novel prognostic biomarker for oral squamous cell carcinoma. Head Neck 2011; 33: 368-74
10. Yuan RH, Wang CC, Chou CC, Chang KJ, Lee PH, Jeng YM,. Diffuse expression of RNA-binding protein IMP3 predicts high-stage lymph node metastasis and poor prognosis in colorectal adenocarcinoma. Ann Surg Oncol 2009; 16: 1711-9
11. Li D, Yan D, Tang H, et al,. IMP3 is a novel prognostic marker that correlates with colon cancer progression and pathogenesis. Ann Surg Oncol 2009; 16: 3499-506
12. Sitnikova L, Mendese G, Liu Q, et al,. IMP3 predicts aggressive superficial urothelial carcinoma of the bladder. Clin Cancer Res 2008; 14: 1701-6 (Pubitemid 351469454)
13. Mori H, Sakakibara S, Imai T, et al,. Expression of mouse igf2 mRNA-binding protein 3 and its implications for the developing central nervous system. J Neurosci Res 2001; 64: 132-43
14. Vikesaa J, Hansen TV, JÃnson L, et al,. RNA-binding IMPs promote cell adhesion and invadopodia formation. EMBO J 2006; 25: 1456-68
15. Livak KJ, Schmittgen TD,. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402-8 (Pubitemid 34164012)
16. Hammer NA, Hansen TO, Byskov AG, et al,. Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer. Reproduction 2005; 130: 203-12 (Pubitemid 41149808)
17. Nemunaitis J, Meyers T, Senzer N, et al,. Phase I Trial of sequential administration of recombinant DNA and adenovirus expressing L523S protein in early stage non-small-cell lung cancer. Mol Ther 2006; 13: 1185-91 (Pubitemid 43796154)
18. Kono K, Mizukami Y, Daigo Y, et al,. Vaccination with multiple peptides derived from novel cancer-testis antigens can induce specific T-cell responses and clinical responses in advanced esophageal cancer. Cancer Sci 2009; 100: 1502-9
19. Bochner BH, Montie JE, Lee CT,. Follow-up strategies and management of recurrence in urologic oncology bladder cancer: invasive bladder cancer. Urol Clin North Am 2003; 30: 777-89 (Pubitemid 37485192)