메뉴 건너뛰기




Volumn 2, Issue 4, 2011, Pages 230-235

Saxagliptin: A dipeptidyl peptidase-4 inhibitor in the treatment of type 2 diabetes mellitus

Author keywords

Dipeptidyl peptidase 4; glycemic control; hypoglycemia; metformin

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; GLIBENCLAMIDE; GLIPIZIDE; METFORMIN; ORAL ANTIDIABETIC AGENT; PLACEBO; SAXAGLIPTIN; SULFONYLUREA DERIVATIVE; VILDAGLIPTIN;

EID: 84865496065     PISSN: 0976500X     EISSN: None     Source Type: Journal    
DOI: 10.4103/0976-500X.85934     Document Type: Article
Times cited : (33)

References (34)
  • 1
    • 79952723297 scopus 로고    scopus 로고
    • Saxagliptin: The evidence for its place in the treatment of type 2 diabetes mellitus
    • Kulasa K, Edelman S. Saxagliptin: The evidence for its place in the treatment of type 2 diabetes mellitus. Core Evid 2010;5:23-37.
    • (2010) Core Evid , vol.5 , pp. 23-37
    • Kulasa, K.1    Edelman, S.2
  • 3
    • 74049094040 scopus 로고    scopus 로고
    • Saxagliptin
    • Dhillon S, Weber J. Saxagliptin. Drugs 2009;69:2103-14.
    • (2009) Drugs , vol.69 , pp. 2103-2114
    • Dhillon, S.1    Weber, J.2
  • 4
    • 75549091263 scopus 로고    scopus 로고
    • Statement by an American association of clinical endocrinologists/ American college of endocrinology consensus panel on type 2 diabetes mellitus: An algorithm for glycemic control
    • Rodbard H W, Jellinger PS, Davidson JA, Einhorn D, Garber AJ, Grunberger G, et al. Statement by an American Association of Clinical Endocrinologists/ American College of Endocrinology consensus panel on type 2 diabetes mellitus: An algorithm for glycemic control. Endocr Pract 2009;15:541-59.
    • (2009) Endocr Pract , vol.15 , pp. 541-559
    • Rodbard, H.W.1    Jellinger, P.S.2    Davidson, J.A.3    Einhorn, D.4    Garber, A.J.5    Grunberger, G.6
  • 5
    • 64749100501 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American diabetes association and the European association for the study of diabetes
    • Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, et al. Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2009;32:193-203.
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3    Ferrannini, E.4    Holman, R.R.5    Sherwin, R.6
  • 7
    • 0014914649 scopus 로고
    • The university group diabetes program: A study of the effect of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. II. Mortality results
    • Meinert CL, Knatterud GL, Prout TE, Klimt CR. The University Group Diabetes Program: A study of the effect of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. II. Mortality results. Diabetes 1970;(Suppl 1):789-830.
    • (1970) Diabetes , Issue.SUPPL. 1 , pp. 789-830
    • Meinert, C.L.1    Knatterud, G.L.2    Prout, T.E.3    Klimt, C.R.4
  • 9
    • 34547700735 scopus 로고    scopus 로고
    • Thiazolidinediones and heart failure: A teleoanalysis
    • Singh S, Loke YK, Furberg CD. Thiazolidinediones and heart failure: A teleoanalysis. Diabetes Care 2007;30:2248-54.
    • (2007) Diabetes Care , vol.30 , pp. 2248-2254
    • Singh, S.1    Loke, Y.K.2    Furberg, C.D.3
  • 10
    • 73449117555 scopus 로고    scopus 로고
    • Saxagliptin: A new DPP-4 inhibitor for the treatment of type 2 diabetes mellitus
    • Tahrani AA, Piya MK, Barnett AH. Saxagliptin: A new DPP-4 inhibitor for the treatment of type 2 diabetes mellitus. Adv Ther 2009;26:249-62.
    • (2009) Adv Ther , vol.26 , pp. 249-262
    • Tahrani, A.A.1    Piya, M.K.2    Barnett, A.H.3
  • 11
    • 64649104158 scopus 로고    scopus 로고
    • From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus
    • Banting Lecture
    • DeFronzo RA. Banting Lecture. From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus. Diabetes 2009;58:773-95.
    • (2009) Diabetes , vol.58 , pp. 773-795
    • DeFronzo, R.A.1
  • 12
    • 79952109097 scopus 로고    scopus 로고
    • Incretin based therapies in the management of type 2 diabetes: Rationale and reality in a managed care setting
    • Garber AJ. Incretin based therapies in the management of type 2 diabetes: Rationale and reality in a managed care setting. Am J Manag Care 2010;16:187-94.
    • (2010) Am J Manag Care , vol.16 , pp. 187-194
    • Garber, A.J.1
  • 13
    • 74249117374 scopus 로고    scopus 로고
    • Role of the incretin pathway in the pathogenesis of type 2 diabetes mellitus
    • Freeman JS. Role of the incretin pathway in the pathogenesis of type 2 diabetes mellitus. Cleve Clin J Med 2009;76 Suppl 5:S12-9.
    • (2009) Cleve Clin J Med , vol.76 , Issue.SUPPL. 5
    • Freeman, J.S.1
  • 14
    • 77953106887 scopus 로고    scopus 로고
    • Type 2 diabetes comorbidities and treatment challenges: Rationale for DPP-4 inhibitors
    • Hollander PA, Kushner P. Type 2 diabetes comorbidities and treatment challenges: Rationale for DPP-4 inhibitors. Postgrad Med 2010;122:71-80.
    • (2010) Postgrad Med , vol.122 , pp. 71-80
    • Hollander, P.A.1    Kushner, P.2
  • 15
    • 70849099404 scopus 로고    scopus 로고
    • Saxagliptin (Onglyza) for type 2 diabetes
    • Saxagliptin (Onglyza) for type 2 diabetes. Med Lett Drugs Ther 2009;51:85-6.
    • (2009) Med Lett Drugs Ther , vol.51 , pp. 85-86
  • 16
    • 77954392632 scopus 로고    scopus 로고
    • Implications of the prolonged dissociation rate of saxagliptin, a highly potent and selective DPP4 inhibitor, on plasma DPP measurements [abstract no. 2088-PO]
    • Wang A, Dorso C, Kopcho L, Marcindeviciene J, Kirby MS. Implications of the prolonged dissociation rate of saxagliptin, a highly potent and selective DPP4 inhibitor, on plasma DPP measurements [abstract no. 2088-PO]. Diabetes 2008;57 Suppl 1:A576-7.
    • (2008) Diabetes , vol.57 , Issue.SUPPL. 1
    • Wang, A.1    Dorso, C.2    Kopcho, L.3    Marcindeviciene, J.4    Kirby, M.S.5
  • 17
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker DJ. The biology of incretin hormones. Cell Metab 2006;3:153-65
    • (2006) Cell Metab , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 18
    • 34249902025 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes - Preclinical biology and mechanisms of action
    • Drucker DJ. Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes - Preclinical biology and mechanisms of action. Diabetes Care 2007;30:1335-43.
    • (2007) Diabetes Care , vol.30 , pp. 1335-1343
    • Drucker, D.J.1
  • 19
    • 66649119188 scopus 로고    scopus 로고
    • Pharmacokinetics of the dipeptidyl peptidase 4 inhibitor saxagliptin in rats, dogs, and monkeys and clinical projections
    • Fura A, Khanna A, Vyas V, Koplowitz B, Chang SY, Caporuscio C, et al. Pharmacokinetics of the dipeptidyl peptidase 4 inhibitor saxagliptin in rats, dogs, and monkeys and clinical projections. Drug Metab Dispos 2009;37:1164-71.
    • (2009) Drug Metab Dispos , vol.37 , pp. 1164-1171
    • Fura, A.1    Khanna, A.2    Vyas, V.3    Koplowitz, B.4    Chang, S.Y.5    Caporuscio, C.6
  • 20
    • 84865459026 scopus 로고    scopus 로고
    • [Last accessed on 2011 Jan 31]
    • Label and approval history of ONGLYZA (saxagliptin): Available from: http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction= Search.Label-ApprovalHistory. [Last accessed on 2011 Jan 31].
    • Label and Approval History of ONGLYZA (saxagliptin)
  • 21
    • 73449110944 scopus 로고    scopus 로고
    • Saxagliptin: A new deipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes
    • Deacon C F, Holst JJ. Saxagliptin: A new deipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes. Adv Ther 2009;26:488-99.
    • (2009) Adv Ther , vol.26 , pp. 488-499
    • Deacon, C.F.1    Holst, J.J.2
  • 24
    • 78349247701 scopus 로고    scopus 로고
    • Role of saxagliptin as monotherapy or adjuct therapy in the treatment of type 2 diabetes
    • Sharma MD. Role of saxagliptin as monotherapy or adjuct therapy in the treatment of type 2 diabetes. Ther Clin Risk Manag 2010;6:233-7.
    • (2010) Ther Clin Risk Manag , vol.6 , pp. 233-237
    • Sharma, M.D.1
  • 25
    • 77958030736 scopus 로고    scopus 로고
    • Efficacy and safety of saxagliptin in combination with metformin compared with sitagliptin in combination with metformin in adult patients with type 2 diabetes mellitus
    • Scheen AJ, Charpentier G, Ostgren CJ, Hellqvist A, Gause-Nilsson I. Efficacy and safety of saxagliptin in combination with metformin compared with sitagliptin in combination with metformin in adult patients with type 2 diabetes mellitus. Diabetes Metab Res Rev 2010;26:540-9.
    • (2010) Diabetes Metab Res Rev , vol.26 , pp. 540-549
    • Scheen, A.J.1    Charpentier, G.2    Ostgren, C.J.3    Hellqvist, A.4    Gause-Nilsson, I.5
  • 26
    • 79955048927 scopus 로고    scopus 로고
    • Saxagliptin improves glycemic control and is well tolerated in patients with type 2 diabetes mellitus (T2DM) and renal impairment
    • Nowicki M, Rychlik I, Haller H, Warren ML, Suchower L, Gausenilsson I. Saxagliptin improves glycemic control and is well tolerated in patients with type 2 diabetes mellitus (T2DM) and renal impairment. Diabetes Obes Metab 2011;13:523-32.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 523-532
    • Nowicki, M.1    Rychlik, I.2    Haller, H.3    Warren, M.L.4    Suchower, L.5    Gausenilsson, I.6
  • 27
    • 42149194313 scopus 로고    scopus 로고
    • Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes
    • Rosenstock J, Sankoh S, List J F. Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes. Diabetes Obes Metab 2008;10:376-86.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 376-386
    • Rosenstock, J.1    Sankoh, S.2    List, J.F.3
  • 29
    • 65549123794 scopus 로고    scopus 로고
    • Saxagliptin given in combination with metformin as initial therapy improves glycaemic control in patients with type 2 diabetes compared with either monotherapy: A randomized controlled trial
    • Jadzinsky M, Pfützner A, Paz-Pacheco E, Xu Z, Allen E, Chen R. Saxagliptin given in combination with metformin as initial therapy improves glycaemic control in patients with type 2 diabetes compared with either monotherapy: A randomized controlled trial. Diabetes Obes Metab 2009;11:611-22.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 611-622
    • Jadzinsky, M.1    Pfützner, A.2    Paz-Pacheco, E.3    Xu, Z.4    Allen, E.5    Chen, R.6
  • 30
    • 73149084956 scopus 로고    scopus 로고
    • CV181-013 investigators. Saxagliptin added to a thiazolidinedione improves glycemic control in patients with type 2 diabetes and inadequate control on thiazolidinedione alone
    • Hollander P, Li J, Allen E, Chen R, CV181-013 Investigators. Saxagliptin added to a thiazolidinedione improves glycemic control in patients with type 2 diabetes and inadequate control on thiazolidinedione alone. J Clin Endocrinol Metab 2009;94:4810-9.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 4810-4819
    • Hollander, P.1    Li, J.2    Allen, E.3    Chen, R.4
  • 31
    • 68949212458 scopus 로고    scopus 로고
    • CV181-040 investigators. Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: A randomised controlled trial
    • Chacra AR, Tan GH, Apanovitch A, Ravichandran S, List J, Chen R; CV181-040 Investigators. Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: A randomised controlled trial. Int J Clin Pract 2009;63:1395-406.
    • (2009) Int J Clin Pract , vol.63 , pp. 1395-1406
    • Chacra, A.R.1    Tan, G.H.2    Apanovitch, A.3    Ravichandran, S.4    List, J.5    Chen, R.6
  • 32
    • 69549135336 scopus 로고    scopus 로고
    • The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes on metformin alone
    • DeFronzo RA, Hissa MN, Garber AJ, Luiz Gross J, Yuyan Duan R, Ravichandran S, et al. The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes on metformin alone. Diabetes Care 2009;32:1649-55.
    • (2009) Diabetes Care , vol.32 , pp. 1649-1655
    • DeFronzo, R.A.1    Hissa, M.N.2    Garber, A.J.3    Luiz Gross, J.4    Yuyan Duan, R.5    Ravichandran, S.6
  • 33
    • 78349292168 scopus 로고    scopus 로고
    • Saxagliptin is non-inferior to glipizide in patients with type 2 diabetes mellitus inadequately controlled on metformin alone: A 52-week randomised controlled trial
    • for the D1680C00001 Investigators
    • Gokes B, Gallwitz B, Eriksson J, Hellqvist A, Gause-Nilsson I, for the D1680C00001 Investigators. Saxagliptin is non-inferior to glipizide in patients with type 2 diabetes mellitus inadequately controlled on metformin alone: A 52-week randomised controlled trial. Int J Clin Pract 2010;64:1619-31.
    • (2010) Int J Clin Pract , vol.64 , pp. 1619-1631
    • Gokes, B.1    Gallwitz, B.2    Eriksson, J.3    Hellqvist, A.4    Gause-Nilsson, I.5
  • 34
    • 77956747341 scopus 로고    scopus 로고
    • Saxagliptin and metformin XR combination therapy provides glycemic control over 24 hours in patients with T2DM inadequately controlled with metformin
    • Stenlof K, Raz I, Neutel J, Ravichandran S, Berglind N, Chen R. Saxagliptin and metformin XR combination therapy provides glycemic control over 24 hours in patients with T2DM inadequately controlled with metformin. Curr Med Res Opin 2010;26:2355-63.
    • (2010) Curr Med Res Opin , vol.26 , pp. 2355-2363
    • Stenlof, K.1    Raz, I.2    Neutel, J.3    Ravichandran, S.4    Berglind, N.5    Chen, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.