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Volumn 50, Issue 10, 2012, Pages 3567-3576

Toxicologic evaluation of DHA-rich algal oil: Genotoxicity, acute and subchronic toxicity in rats

Author keywords

Algal oil; DHA; DHA rich algal oil ONC T18; Subchronic toxicity

Indexed keywords

ALGAL EXTRACT; ALGAL OIL; DOCOSAHEXAENOIC ACID; UNCLASSIFIED DRUG;

EID: 84865490256     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.07.054     Document Type: Article
Times cited : (29)

References (33)
  • 1
    • 0016685233 scopus 로고
    • Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test
    • Ames B.N., McCann J., Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat. Res. 1975, 31:347-364.
    • (1975) Mutat. Res. , vol.31 , pp. 347-364
    • Ames, B.N.1    McCann, J.2    Yamasaki, E.3
  • 4
    • 0000223087 scopus 로고
    • Properties of sufficiency and statistical tests
    • Bartlett M.S. Properties of sufficiency and statistical tests. Proc. R. Statistical Soc. Ser. A 1937, 160:268-282.
    • (1937) Proc. R. Statistical Soc. Ser. A , vol.160 , pp. 268-282
    • Bartlett, M.S.1
  • 5
    • 0022836974 scopus 로고
    • Metabolism of arachidonic and docosahexaenoic acids in the retina
    • Bazan N.G., Reddy T.S., Bazan H.E., Birkle D.L. Metabolism of arachidonic and docosahexaenoic acids in the retina. Prog. Lipid Res. 1986, 25(1-4):595-606.
    • (1986) Prog. Lipid Res. , vol.25 , Issue.1-4 , pp. 595-606
    • Bazan, N.G.1    Reddy, T.S.2    Bazan, H.E.3    Birkle, D.L.4
  • 6
    • 36049037226 scopus 로고    scopus 로고
    • Genotoxicity and subchronic toxicity studies of DHA-rich oil in rats
    • Blum R., Kiy T., Tanaka S., Wong A.W., Roberts A. Genotoxicity and subchronic toxicity studies of DHA-rich oil in rats. Regul. Toxicol. Pharm. 2007, 49:271-284.
    • (2007) Regul. Toxicol. Pharm. , vol.49 , pp. 271-284
    • Blum, R.1    Kiy, T.2    Tanaka, S.3    Wong, A.W.4    Roberts, A.5
  • 7
    • 33749818282 scopus 로고    scopus 로고
    • Isolation and characterization of polyunsaturated fatty acid producing Thraustochytrium species: screening of strains and optimization of omega-3 production
    • Burja A.M., Radianingtyas H., Windust A., Barrow C.J. Isolation and characterization of polyunsaturated fatty acid producing Thraustochytrium species: screening of strains and optimization of omega-3 production. Appl. Microbiol. Biotechnol. 2006, 72:1161-1169.
    • (2006) Appl. Microbiol. Biotechnol. , vol.72 , pp. 1161-1169
    • Burja, A.M.1    Radianingtyas, H.2    Windust, A.3    Barrow, C.J.4
  • 8
    • 0032927707 scopus 로고    scopus 로고
    • Evaluation of single-cell sources of docosahexaenoic acid and arachidonic acid: 3-month rat oral safety study with an in utero phase
    • Burns R.A., Wibert G.J., Diersen-Schade D.A., Kelly C.M. Evaluation of single-cell sources of docosahexaenoic acid and arachidonic acid: 3-month rat oral safety study with an in utero phase. Food Chem. Toxicol. 1999, 37:23-36.
    • (1999) Food Chem. Toxicol. , vol.37 , pp. 23-36
    • Burns, R.A.1    Wibert, G.J.2    Diersen-Schade, D.A.3    Kelly, C.M.4
  • 10
    • 84861604521 scopus 로고
    • Multiple contrasts using rank sums
    • Dunn O.J. Multiple contrasts using rank sums. Technometrics 1964, 6:241-252.
    • (1964) Technometrics , vol.6 , pp. 241-252
    • Dunn, O.J.1
  • 11
    • 0000080398 scopus 로고
    • New tables for multiple comparisons with a control
    • Dunnett C.W. New tables for multiple comparisons with a control. Biometrics 1964, 482-491.
    • (1964) Biometrics , pp. 482-491
    • Dunnett, C.W.1
  • 12
    • 0001277372 scopus 로고
    • Pairwise multiple comparisons in the unequal variance case
    • Dunnett C.W. Pairwise multiple comparisons in the unequal variance case. J. Amer. Statist. Assoc. 1980, 75:796-800.
    • (1980) J. Amer. Statist. Assoc. , vol.75 , pp. 796-800
    • Dunnett, C.W.1
  • 13
    • 84860172556 scopus 로고    scopus 로고
    • Agency response letter GRAS Notice No. GRN 000319. August 4.
    • U.S. Food and Drug Administration (FDA). 2010. Agency response letter GRAS Notice No. GRN 000319. August 4.
    • (2010) U.S. Food and Drug Administration (FDA).
  • 17
    • 0034998293 scopus 로고    scopus 로고
    • Safety assessment of DHA-rich microalgae from Schizochytrium sp. Part II. Developmental toxicology evaluation in rats and rabbits
    • Hammond B.G., Mayhew D.A., Holson J.F., Nemec M.D., Mast R.W., Sander W.J. Safety assessment of DHA-rich microalgae from Schizochytrium sp. Part II. Developmental toxicology evaluation in rats and rabbits. Regul. Toxicol. Pharmacol. 2001, 33:205-217.
    • (2001) Regul. Toxicol. Pharmacol. , vol.33 , pp. 205-217
    • Hammond, B.G.1    Mayhew, D.A.2    Holson, J.F.3    Nemec, M.D.4    Mast, R.W.5    Sander, W.J.6
  • 18
    • 0034952058 scopus 로고    scopus 로고
    • Safety assessment of DHA-rich microalgae from Schizochytrium sp. Part III. Single generation rat reproduction study
    • Hammond B.G., Mayhew D.A., Robinson K., Mast R.W., Sander W.J. Safety assessment of DHA-rich microalgae from Schizochytrium sp. Part III. Single generation rat reproduction study. Regul. Toxicol. Pharm. 2001, 33:356-362.
    • (2001) Regul. Toxicol. Pharm. , vol.33 , pp. 356-362
    • Hammond, B.G.1    Mayhew, D.A.2    Robinson, K.3    Mast, R.W.4    Sander, W.J.5
  • 19
    • 0036085491 scopus 로고    scopus 로고
    • Safety assessment of DHA-rich microalgae from Schizochytrium sp. Part IV. Mutagenicity studies
    • Hammond B.G., Mayhew D.A., Kier L.D., Mast R.W., Sander W.J. Safety assessment of DHA-rich microalgae from Schizochytrium sp. Part IV. Mutagenicity studies. Regul. Toxicol.Pharm. 2002, 35:255-265.
    • (2002) Regul. Toxicol.Pharm. , vol.35 , pp. 255-265
    • Hammond, B.G.1    Mayhew, D.A.2    Kier, L.D.3    Mast, R.W.4    Sander, W.J.5
  • 20
    • 0034009797 scopus 로고    scopus 로고
    • Evaluation of a subchronic (13-week) oral toxicity study, preceded by an in utero exposure phase, with arachidonic acid oil derived from Mortierella alpina in rats
    • Hempenius R.A., Lina B.A.R., Haggitt R.C. Evaluation of a subchronic (13-week) oral toxicity study, preceded by an in utero exposure phase, with arachidonic acid oil derived from Mortierella alpina in rats. Food Chem. Toxicol. 2000, 38:127-139.
    • (2000) Food Chem. Toxicol. , vol.38 , pp. 127-139
    • Hempenius, R.A.1    Lina, B.A.R.2    Haggitt, R.C.3
  • 21
    • 0033009199 scopus 로고    scopus 로고
    • Antioxidative effects of docosahexaenoic acid in the cerebrum versus cerebellum and brainstem of aged hypercholesterolemic rats
    • Hossain M.S., Hashimoto M., Gamoh S., Masumura S. Antioxidative effects of docosahexaenoic acid in the cerebrum versus cerebellum and brainstem of aged hypercholesterolemic rats. J. Neurochem. 1999, 72(3):1133-1138.
    • (1999) J. Neurochem. , vol.72 , Issue.3 , pp. 1133-1138
    • Hossain, M.S.1    Hashimoto, M.2    Gamoh, S.3    Masumura, S.4
  • 22
    • 17044395109 scopus 로고    scopus 로고
    • Essential fatty acid transfer and fetal development
    • Innis S.M. Essential fatty acid transfer and fetal development. Placenta 2005, 26(Suppl. A):S70-S75.
    • (2005) Placenta , vol.26 , Issue.SUPPL. A
    • Innis, S.M.1
  • 24
    • 84943709252 scopus 로고
    • Use of ranks in one-criterion analysis of variance
    • Kruskal W.H., Wallis W.A. Use of ranks in one-criterion analysis of variance. J. Amer. Statist. Assoc. 1952, 47:583-621.
    • (1952) J. Amer. Statist. Assoc. , vol.47 , pp. 583-621
    • Kruskal, W.H.1    Wallis, W.A.2
  • 25
    • 0033030601 scopus 로고    scopus 로고
    • Plausible explanations for effects of long chain polyunsaturated fatty acids (LCPUFA) on neonates
    • Kurlak L.O., Stephenson T.J. Plausible explanations for effects of long chain polyunsaturated fatty acids (LCPUFA) on neonates. Arch. Dis. Child. Fetal Neonatal Ed. 1999, 80(2):F148-F154.
    • (1999) Arch. Dis. Child. Fetal Neonatal Ed. , vol.80 , Issue.2
    • Kurlak, L.O.1    Stephenson, T.J.2
  • 26
    • 0003139708 scopus 로고
    • Robust test for equality of variances
    • Stanford University Press, Palo Alto, J. Olkin (Ed.)
    • Levene H. Robust test for equality of variances. Contributions to probability and statistics 1960, 278-292. Stanford University Press, Palo Alto. J. Olkin (Ed.).
    • (1960) Contributions to probability and statistics , pp. 278-292
    • Levene, H.1
  • 27
    • 28844477192 scopus 로고    scopus 로고
    • Subchronic (13-week) oral toxicity study, preceded by an in utero exposure phase, with arachidonate enriched triglyceride oil (SUNTGA40S) in rats
    • Lina B.A.R., Wolterbeek A.P.M., Suwa Y., Fujikawa S., Ishikura Y., Tsuda S., Dohnalek M. Subchronic (13-week) oral toxicity study, preceded by an in utero exposure phase, with arachidonate enriched triglyceride oil (SUNTGA40S) in rats. Food Chem. Toxicol. 2006, 44:326-335.
    • (2006) Food Chem. Toxicol. , vol.44 , pp. 326-335
    • Lina, B.A.R.1    Wolterbeek, A.P.M.2    Suwa, Y.3    Fujikawa, S.4    Ishikura, Y.5    Tsuda, S.6    Dohnalek, M.7
  • 28
    • 0020533372 scopus 로고
    • Revised methods for the Salmonella mutagenicity test
    • Maron D.M., Ames B. Revised methods for the Salmonella mutagenicity test. Mutation Res. 1983, 113:173-215.
    • (1983) Mutation Res. , vol.113 , pp. 173-215
    • Maron, D.M.1    Ames, B.2
  • 29
    • 28444434796 scopus 로고    scopus 로고
    • Docosahexaenoic acid, fatty acid-interacting proteins, and neuronal function: breastmilk and fish are good for you
    • Marszalek J.R., Lodish H.E. Docosahexaenoic acid, fatty acid-interacting proteins, and neuronal function: breastmilk and fish are good for you. Annu. Rev. Cell Dev. Biol. 2005, 21:633-657.
    • (2005) Annu. Rev. Cell Dev. Biol. , vol.21 , pp. 633-657
    • Marszalek, J.R.1    Lodish, H.E.2
  • 30
    • 0001979310 scopus 로고
    • The Micronucleus Test for Cytogenetic Analysis
    • ed., Hollaender, A., Plenum Press.
    • Schmid, W. 1976. The Micronucleus Test for Cytogenetic Analysis, Chemical Mutagens, Principles and Methods for Their Detection, ed., Hollaender, A., Vol. 4, pp. 31-53, Plenum Press.
    • (1976) Chemical Mutagens, Principles and Methods for Their Detection , vol.4 , pp. 31-53
    • Schmid, W.1
  • 31
    • 0000898845 scopus 로고
    • An analysis of variance test for normality (complete samples)
    • Shapiro S.S., Wilk M.B. An analysis of variance test for normality (complete samples). Biometrika 1965, 52:591-611.
    • (1965) Biometrika , vol.52 , pp. 591-611
    • Shapiro, S.S.1    Wilk, M.B.2
  • 32
    • 77949518826 scopus 로고    scopus 로고
    • Agency response letter GRAS Notice No. GRN 000137. February 12.
    • U.S. Food and Drug Administration (FDA). 2004a. Agency response letter GRAS Notice No. GRN 000137. February 12.
    • (2004) U.S. Food and Drug Administration (FDA).
  • 33
    • 77949518826 scopus 로고    scopus 로고
    • Agency response letter GRAS Notice No. GRN 000138. April 20.
    • U.S. Food and Drug Administration (FDA). 2004b. Agency response letter GRAS Notice No. GRN 000138. April 20.
    • (2004) U.S. Food and Drug Administration (FDA).


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