N,O6-partially acetylated chitosan nanoparticles hydrophobically-modified for controlled release of steroids and vitamin e

Carbohydrate Polymers

Volumn 91, Issue 1, 2013, Pages 143-151

  Quiñones, Javier Pérez ^a   Gothelf, Kurt Vesterager ^b   Kjems, Jorgen ^b   Caballero, Ángeles María Heras ^c   Schmidt, Claudia ^d   Covas, Carlos Peniche ^a  

^a UNIVERSITY OF HAVANA   (Cuba)

^b AARHUS UNIVERSITY   (Denmark)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d UNIVERSITY OF PADERBORN   (Germany)

Author keywords

Chitosan; Controlled release; Self assembled nanoparticles; Steroids; Tocopherol

Indexed keywords

ACETYLATED CHITOSAN; BRASSINOSTEROIDS; CONSTANT RELEASE; CONTROLLED RELEASE; DRUG CONTENT; DRUG RELEASE; FTIR SPECTROSCOPY; IN-VITRO; PROTON NMR; RADICAL SCAVENGING ACTIVITY; SELF ASSEMBLED NANOPARTICLES; STEROIDS; SUBSTITUTION DEGREE; SYNTHETIC ANALOGS; TOCOPHEROL; VITAMIN-E; WIDE-ANGLE X-RAY DIFFRACTION;

BIOASSAY; CHITOSAN; DIFFERENTIAL SCANNING CALORIMETRY; FOURIER TRANSFORM INFRARED SPECTROSCOPY; LIPIDS; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION;

NANOPARTICLES;

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2,2-DIPHENYL-1-PICRYLHYDRAZYL; BIPHENYL DERIVATIVE; BRASSINOSTEROID; CHITOSAN; DRUG CARRIER; NANOPARTICLE; PHYTOHORMONE; PICRIC ACID; SCAVENGER; TOCOPHEROL;

ACETYLATION; ARTICLE; CHEMICAL PHENOMENA; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; RAPHANUS;

ACETYLATION; BIPHENYL COMPOUNDS; BRASSINOSTEROIDS; CHITOSAN; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; FREE RADICAL SCAVENGERS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; NANOPARTICLES; PICRATES; PLANT GROWTH REGULATORS; RAPHANUS; TOCOPHEROLS;

RAPHANUS SATIVUS;

EID: 84865468495     PISSN: 01448617     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carbpol.2012.07.080     Document Type: Article

References (16)

1. Abe, T.; Hasunuma, K.; & Kurokawa, M. (1976). Vitamin E orotate and a method of producing the same. US: 3,944,550.
2. Alonso, E.; Cabrera, M.; Coll, F.; Jomarrón, I.; Robaina, C. (1995). Polyhydroxyspirostanones as growth plants regulators. PTC Int. Appl.; WO 9,713,780 (CA 126: 343,720).
3. E. Alonso-Becerra, Y. Bernardo-Otero, F. Coll-Manchado, F. Guerra-Martínez, G. Martínez-Massanet, and C. Pérez- Martínez Synthesis and biological activity of epoxy analogues of 3-dehydroteasterone Journal of Chemical Research 5 2007 268 271
4. 1H NMR method for the determination of the degree of deacetylation of chitosan Journal of Pharmaceutical and Biomedical Analysis 32 2003 1149 1158
5. C. Damodaran, S. Koduru, R. Kumar, N. Kyprianou, S. Srinivasan, and G. Venguswamy Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells International Journal of Cancer 125 2009 961 967
6. L. David, A. Domard, J-M. Lucas, A. Osorio-Madrazo, C. Peniche-Covas, and S. Trombotto Kinetics study of the solid-state acid hydrolysis of chitosan: Evolution of the crystallinity and macromolecular structure Biomacromolecules 11 2010 1376 1386
7. X. Hu, K. Tang, Y. Yang, Y. Zhang, and G. Zou Preparation and characterization of self-assembled nanoparticles of 6-O-cholesterol-modified chitosan for drug delivery Journal of Applied Polymer Science 107 2008 891 897
8. Y. Jing-Mou, Q. Li-Yan, J. Yi, and L. Yong-Jie Self-aggregated nanoparticles of cholesterol-modified glycol chitosan conjugate: Preparation, characterization, and preliminary assessment as a new drug delivery carrier European Polymer Journal 44 2008 555 565
9. T. Kean, and M. Thanou Biodegradation, biodistribution and toxicity of chitosan Advanced Drug Delivery Reviews 62 2010 3 11
10. J.-L. Mau, J. Yang, and M.-T. Yen Physicochemical characterization of chitin and chitosan from crab shells Carbohydrate Polymers 75 2009 15 21
11. R.A.A. Muzzarelli Chitins and chitosans for the repair of wounded skin, nerve, cartilage and bone Carbohydrate Polymers 76 2 2009 167 182
12. R.A.A. Muzzarelli, J. Boudrant, D. Meyer, N. Manno, M. De Marchis, and M.G. Paoletti Current views on fungal chitin/chitosan, human chitinases, food preservation, glucans, pectins and inulin: A tribute to Henri Braconnot, precursor of the carbohydrate polymers science, on the chitin bicentennial Carbohydrate Polymers 87 2012 995 1012
13. J.P. Quiñones, R. Szopko, C. Schmidt, and C.P. Covas Novel drug delivery systems: Chitosan conjugates covalently attached to steroids with potential anticancer and agrochemical activity Carbohydrate Polymers 84 3 2011 858 864
14. D. Raafat, and H.-G. Sahl Chitosan and its antimicrobial potential - a critical literature survey Microbial Biotechnology 2 2 2009 186 201
15. M.N.V. Ravi Kumar, R.A.A. Muzzarelli, C. Muzzarelli, H. Sashiwa, and A.J. Domb Chitosan chemistry and pharmaceutical perspectives Chemical Reviews 104 2004 6017 6084
16. H. Sashiwa, N. Kawasaki, A. Nakayama, E. Muraki, N. Yamamoto, and S. Aiba Chemical modification of chitosan. 14:1 synthesis of water-soluble chitosan derivatives by simple acetylation Biomacromolecules 3 2002 1126 1128