The bioassay-guided isolation of growth inhibitors of adult T-cell leukemia (ATL), from the jamaican plant Hyptis verticillata, and NMR characterization of hyptoside

Molecules

Volumn 17, Issue 8, 2012, Pages 9931-9938

  Hamada, Toshiyuki ^a   White, Yohann ^b   Nakashima, Mitsuyoshi ^a   Oiso, Yusuke ^a   Fujita, Masaki J ^c   Okamura, Hiroaki ^a   Iwagawa, Tetsuo ^a   Arima, Naomichi ^b  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

Author keywords

ATL; Bioassay guided isolation; Growth inhibitor; Lignan; NMR; S1T; Structure

Indexed keywords

ANTINEOPLASTIC AGENT; GROWTH INHIBITOR; PLANT EXTRACT;

APOPTOSIS; ARTICLE; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; HUMAN; HYPTIS; IC 50; ISOLATION AND PURIFICATION; NUCLEAR MAGNETIC RESONANCE; PLANT; T CELL LEUKEMIA; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; GROWTH INHIBITORS; HUMANS; HYPTIS; INHIBITORY CONCENTRATION 50; LEUKEMIA-LYMPHOMA, ADULT T-CELL; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS;

EID: 84865459838     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules17089931     Document Type: Article

References (15)

1. Arisawa, K.; Soda, M.; Endo, S.; Kurokawa, K.; Katamine, S.; Shimokawa, I.; Koba, T.; Takahashi, T.; Saito, H.; Doi, H.; et al. Evaluation of adult T-cell leukemia/lymphoma incidence and its impact on non-Hodgkin lymphoma incidence in southwestern Japan. Int. J. Cancer 2000, 85, 319-324.
2. Proietti, F.A.; Carneiro-Proietti, A.B.; Catalan-Soares, B.C.; Murphy, E.L. Global epidemiology of HTLV-I infection and associated diseases. Oncogene 2005, 24, 6058-6068.
3. Yamada, Y.; Tomonaga, M.; Fukuda, H.; Hanada, S.; Utsunomiya, A.; Tara, M.; Sano, M.; Ikeda, S.; Takatsuki, K.; Kozuru, M.; et al. A new G-CSF-supported combination chemotherapy, LSG15, for adult T-cell leukaemia-lymphoma: Japan Clinical Oncology Group Study 9303. Br. J. Haematol. 2001, 113, 375-382.
4. Heinrich, M.; Rimpler, H.; Barrera, N.A. Indigenous phytotherapy of gastrointestinal disorders in a lowland mixed community (Oaxaca, Mexico) - Ethnopharmacological evaluation. J. Ethnopharmacol. 1992, 36, 63-80.
5. Heinrich, M.; Kuhnt, M.; Wright, C.W.; Rimpler, C.W.; Phillipson, J.D.; Schandelmaier, A.; Warhurst, D.C. Parasitological and microbiological evaluation of Mixe Indian medicinal-plants (Mexico). J. Ethnopharmacol. 1992, 36, 81-85.
6. Novelo, M.; Cruz, J.G.; Hernandez, L.; Pereda-Miranda, R.; Chai, H.; Mar, W.; Pezzuto, J.M. Cytotoxic constituents from Hyptis-verticillata. VI. Chemical studies on Mexican Hyptis species and II. biologically-active natural-products from Mexican medicinal-plants. J. Nat. Prod. 1993, 56, 1728-1736.
7. Kuhnt, M.; Rimpler, H.; Heinrich, M. Lignans and other compounds from the Mixe-Indian medicinal plant Hyptis-verticillata. Phytochemistry 1994, 36, 485-489.
8. Porter, R.B.; Reese, P.B.; Williams, L.A.D.; Williams, D.J. Acaricidal and insecticidal activities of cadina-4,10(15)-dien-3-one. Phytochemistry 1995, 40, 735-738.
9. Collins, D.O.; Buchanan, G.O.; Reynolds, W.F.; Reese, P.B. Biotransformation of squamulosone by Curvularia lunata ATCC 12017. Phytochemistry 2001, 57, 377-383.
10. Facey, P.C.; Porter, R.B.R.; Reese, P.B.; Williams, L.A.D. Biological activity and chemical composition of the essential oil from Jamaican Hyptis verticillata Jacq. J. Agric. Food Chem. 2005, 53, 4774-4777.
11. White, Y.; Hamada, T.; Yoshimitsu, M.; Nakashima, M.; Hachiman, M.; Kozako, T.; Matsushita, K.; Uozumi, K.; Suzuki, S.; Kofune, H.; et al. Novel cytotoxic isolated from Jamaican Hyptis verticillata jacq induces apoptosis and overcomes multidrug resistance. Anticancer Res. 2011, 31, 4251-4258.
12. German, V.F. Isolation and characterization of cytotoxic principles from Hyptis verticillata. J. Pharm. Sci. 1971, 60, 649-650.
13. Jackson, D.E.; Dewick, P.M. Aryltetralin lignans from Podophyllum-hexandrum and Podophyllum-peltatum. Phytochemistry 1984, 23, 1147-1152.
14. Dewick, P.M.; Jackson, D.E. Cyto-toxic lignans from Podophyllum, and the nomenclature of aryltetralin lignans. Phytochemistry 1981, 20, 2277-2280.
15. Gordaliza, M.; Castro, M.A.; del Corral, J.M.M.; San Feliciano, A. Antitumor properties of podophyllotoxin and related compounds. Curr. Pharm. Des. 2000, 6, 1811-1839.