Direct and quantitative analysis of underivatized acylcarnitines in serum and whole blood using paper spray mass spectrometry

Analytical and Bioanalytical Chemistry

Volumn 404, Issue 5, 2012, Pages 1389-1397

  Yang, Qian ^a   Manicke, Nicholas E ^b   Wang, He ^a   Petucci, Christopher ^c   Cooks, R Graham ^b   Ouyang, Zheng ^a,b  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c BURNHAM INSTITUTE   (United States)

Author keywords

Acylcarnitines; Ambient ionization; Mass spectrometry; Newborn screening; Paper spray

Indexed keywords

ACYLCARNITINES; BLOOD SAMPLES; CONCENTRATION RANGES; CRITICAL FACTORS; CUT-OFF VALUE; DERIVATIZATIONS; FATTY ACID OXIDATION; HIGH REPRODUCIBILITY; HIGH SENSITIVITY; LIMITS OF QUANTITATIONS; MATRIX COMPONENTS; NEWBORN SCREENING; OPTIMAL SIGNALS; PAPER-TYPE; RAPID METHOD; REPRODUCIBILITIES; SAMPLE PRETREATMENT; SERUM SAMPLES; SIGNAL INTENSITIES; SIMPLE PROTOCOL; WHOLE BLOOD;

IMAGING TECHNIQUES; MASS SPECTROMETRY; SOLVENTS; TISSUE;

BLOOD;

ACYLCARNITINE; CARNITINE; DRUG DERIVATIVE;

ARTICLE; BLOOD; DISORDERS OF LIPID AND LIPOPROTEIN METABOLISM; DRIED BLOOD SPOT TESTING; ECONOMICS; HUMAN; LIMIT OF DETECTION; MASS SPECTROMETRY; METHODOLOGY; NEWBORN; REPRODUCIBILITY; TIME; VALIDATION STUDY;

CARNITINE; DRIED BLOOD SPOT TESTING; HUMANS; INFANT, NEWBORN; LIMIT OF DETECTION; LIPID METABOLISM, INBORN ERRORS; MASS SPECTROMETRY; REPRODUCIBILITY OF RESULTS; TIME FACTORS;

EID: 84865452206     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-012-6211-4     Document Type: Article

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