Isolation, biological activity evaluation, structure elucidation, and total synthesis of eliamid: A novel complex i inhibitor

Chemistry - A European Journal

Volumn 18, Issue 36, 2012, Pages 11362-11370

  Höfle, Gerhard ^a   Gerth, Klaus ^a   Reichenbach, Hans ^a   Kunze, Brigitte ^a   Sasse, Florenz ^a   Forche, Edgar ^a   Prusov, Evgeny V ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

complex I inhibitors; natural products; structure elucidation; tetramic acids; total synthesis

Indexed keywords

ABSOLUTE CONFIGURATION; AMIDE MOIETIES; BACTERIAL STRAINS; CARCINOMA CELL LINES; CYTOSTATIC; DIFFERENTIAL SPECTROSCOPY; FEEDING EXPERIMENTS; LINEAR SEQUENCE; MUKAIYAMA ALDOL REACTION; MYXOBACTERIA; NATURAL PRODUCTS; OXIDOREDUCTASES; PENTAFLUOROPHENYL; POLYKETIDES; POTENT INHIBITOR; SECONDARY METABOLITES; STEREOCENTERS; STEREOGENIC CENTERS; STRUCTURAL SIMILARITY; STRUCTURE ELUCIDATION; SUBMITOCHONDRIAL PARTICLES; TETRAMIC ACIDS; TOTAL SYNTHESIS;

AMIDES; CELL CULTURE; CONDENSATION REACTIONS; DEGRADATION; EXPERIMENTS; KETONES; METABOLITES; MOLECULES; ORGANIC ACIDS;

BIOACTIVITY;

2 PYRROLIDONE DERIVATIVE; ANTIFUNGAL AGENT; CYTOSTATIC AGENT; ELIAMID; ENZYME INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ANIMAL; ARTICLE; CATTLE; CELL LINE; CELL PROLIFERATION; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; FUNGUS; HEART; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MICROBIAL SENSITIVITY TEST; MOUSE; MYXOCOCCALES; OXIDATION REDUCTION REACTION; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIFUNGAL AGENTS; CATTLE; CELL LINE; CELL PROLIFERATION; CYTOSTATIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT COMPLEX I; ENZYME INHIBITORS; FUNGI; HEART; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MYXOCOCCALES; NAD; OXIDATION-REDUCTION; PYRROLIDINONES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84865448947     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201201879     Document Type: Article

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