Renal responses to chronic suppression of central sympathetic outflow

Hypertension

Volumn 60, Issue 3, 2012, Pages 749-756

  Iliescu, Radu ^a,b   Irwin, Eric D ^c   Georgakopoulos, Dimitrios ^d   Lohmeier, Thomas E ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^b GRIGORE T POPA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^c NORTH MEMORIAL MEDICAL CENTER   (United States)

^d CVRX INC   (United States)

Author keywords

arterial pressure; baroreflex; renal function; renal nerves; renin angiotensin system; sympathetic nervous system

Indexed keywords

AMLODIPINE; NORADRENALIN; RENIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAROTID SINUS PRESSORECEPTOR REFLEX; CONTROLLED STUDY; DRUG EFFECT; EXPERIMENTAL DOG; FEEDBACK SYSTEM; GLOMERULUS FILTRATION RATE; KIDNEY BLOOD FLOW; KIDNEY TUBULE ABSORPTION; LONG TERM CARE; MACULA DENSA; MEAN ARTERIAL PRESSURE; NONHUMAN; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RESISTANT HYPERTENSION; SODIUM ABSORPTION; SODIUM BALANCE; SYMPATHETIC NERVE; SYMPATHETIC TONE; TREATMENT RESPONSE;

AMLODIPINE; ANIMALS; BAROREFLEX; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; CAROTID ARTERIES; DOGS; ELECTRIC STIMULATION; GLOMERULAR FILTRATION RATE; KIDNEY; MODELS, ANIMAL; NOREPINEPHRINE; REGIONAL BLOOD FLOW; RENIN; SODIUM; SYMPATHETIC NERVOUS SYSTEM;

EID: 84865448503     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.112.193607     Document Type: Article

References (26)

1. Lohimeier TE, Iliescu R. Chronic lowering of blood pressure by carotid baroreflex activation: mechanisms and potential for hypertension therapy. Hypertension. 2011;57:880-886.
2. Bisognano JD, Bakris G, Nadim MK, Sanchez L, Kroon AA, Schafer J, de Leeuw PW, Sica DA. Baroreflex activation therapy lowers blood pressure in patients with resistant hypertension: results from the doubleblind, randomized, placebo-controlled Rheos Pivotal trial. J Am Coll Cardiol. 2011;58:765-773.
3. Guyton AC. Arterial Pressure and Hypertension. Philadelphia, PA:Saunders; 1980.
4. Cowley AW Jr. Long-term control of arterial blood pressure. Physiol Rev. 1992;72:231-300.
5. Calhoun DA, Jones D, Textor S, Goff DC, Murphy TP, Toto RD, White A, Cushman WC, White W, Sica D, Ferdinand K, Giles TD, Falkner B, Carey RM. Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension. 2008;117:e510-e526.
6. Persell SD. Prevalence of resistant of resistant hypertension in the United States, 2003-2008. Hypertension. 2011;57:1076-1080.
7. Lohmeier TE, Iliescu R, Liu B, Henegar JR, Maric-Bilkan C, Irwin ED. Systemic and renal-specific sympathoinhibition in obesity hypertension. Hypertension. 2012;59:331-338.
8. Lohmeier TE, Irwin ED, Rossing MA, Sedar DJ, Kieval RS. Prolonged activation of the baroreflex produces sustained hypotension. Hypertension. 2004;43:306-311.
9. Lohmeier TE, Dwyer TM, Hildebrandt DA, Irwin ED, Rossing MA, Serdar DJ, Kieval RS. Influence of prolonged baroreflex activation on arterial pressure in angiotensin hypertension. Hypertension. 2005;46:1194-1200.
10. Lohmeier TE, Hildebrandt DA, Dwyer TM, Iliescu R, Irwin ED, Cates AW, Rossing M. Prolonged activation of the baroreflex decreases arterial pressure even during adrenergic blockade. Hypertension. 2009;53:833-838.
11. Lohmeier TE, Iliescu R, Dwyer TM, Irwin ED, Cates AW, Rossing MA. Sustained suppression of sympathetic activity and arterial pressure during chronic activation of the carotid baroreflex. Am J Physiol Heart Circ Physiol. 2010;299:H402-H409.
12. Griffin KA, Picken M, Bakris GL, Bidani AK. Comparative effects of selective T-and L-type calcium channel blockers in the remnant kidney model. Hypertension. 2001;37:1268-1272.
13. Bidani AK, Griffin KA. Pathophysiology of hypertensive renal damage: implications for therapy. Hypertension. 2004;44:595-601.
14. Lohmeier TE, Lohmeier JR, Haque A, Hildebrandt DA. Baroreflexes prevent neurally-induced sodium retention in angiotensin hypertension. Am J Physiol Regulatory Integrative Comp Physiol. 2000;279:R1437-R1448.
15. Lohmeier TE, Hildebrandt DA, Warren S, May PJ, Cunningham JT. Recent insights into the interactions between the baroreflex and the kidneys in hypertension. Am J Physiol Regulatory Integrative Comp Physiol. 2005;288:R828-R836.
16. Lohmeier TE, Drummond HA. The baroreflex in the pathogenesis of hypertension. In: Lip GYH, Hall JE, ed. Comprehensive Hypertension. New York, NY: Elsevier; 2007:265-279.
17. Malpas SC. Sympathetic nervous system overactivity and its role in the development of cardiovascular diseases. Physiol Rev. 2010;90:513-557.
18. Lohmeier TE, Hildebrandt DA, Dwyer TM, Barrett AM, Irwin ED, Rossing MA, Kieval RS. Renal denervation does not abolish sustained baroreflex-mediated reductions in arterial pressure. Hypertension. 2007; 49:373-379.
19. Iliescu R, Lohmeier TE. Lowering of blood pressure during chronic suppression of central sympathetic outflow: insight from computer simulations. Clin Exp Pharmacol Physiol. 2010;37:e24-e33.
20. Hall JE. The kidney, hypertension, and obesity. Hypertension. 2003; 41(part 2):625-633.
21. Osborn JW, Averina VA, Fink GD. Current computational models do not reveal the importance of the nervous system in long-term control of arterial pressure. Exp Physiol 2009:94;389-396.
22. Hester RL, Brown AJ, Husband L, Iliescu R, Pruett D, Summers R, Coleman TC. HumMod: a modeling environment for the simulation of integrative human physiology. Front Physiol. 2011;2:1-12.
23. DiBona GF, Kopp UC. Neural control of renal function. Physiol Rev. 1997;77:75-197.
24. Woods LL, Mizelle HL, Montani J-P, Hall JE. Mechanisms controlling renal hemodynamics and electrolyte excretion during amino acids. Am J Physiol Renal Fluid Electrolyte Physiol. 1986;251: F303-F312.
25. Woods LL, De Young DR, Smith BE. Regulation of renal hemodynamics after protein feeding: effects of loop diuretics. Am J Physiol Renal Fluid Electrolyte Physiol. 1991;261:F815-F823.
26. Woods LL, Smith BE, De Young. Regulation of renal hemodynamics after protein feeding: effects of proximal and distal diuretics. Am J Physiol Regulatory Integrative Comp Physiol. 1993;264:R337-R344.