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Volumn 23, Issue 6, 2012, Pages 482-493

Anticoagulant therapy: Basic principles, classic approaches and recent developments

Author keywords

antiplatelet agents; antithrombotic therapy; blood coagulation; dabigatran; direct thrombin inhibitors; heparin; thrombosis; vitamin K antagonists; warfarin

Indexed keywords

ABCIXIMAB; ACETYLSALICYLIC ACID; ACTIVATED PROTEIN C; ANTICOAGULANT AGENT; ANTITHROMBIN; ANTIVITAMIN K; APIXABAN; ARGATROBAN; BLOOD CLOTTING FACTOR 10A INHIBITOR; CLOPIDOGREL; DABIGATRAN; EDOXABAN; FIBRIN; FIBRINOGEN RECEPTOR; FONDAPARINUX; HEPARIN; HIRUDIN; LOW MOLECULAR WEIGHT HEPARIN; PROTEINASE ACTIVATED RECEPTOR 1; PROTHROMBIN; PROTHROMBIN A; PURINERGIC P2Y12 RECEPTOR; RIVAROXABAN; THROMBIN; THROMBIN INHIBITOR; THROMBOMODULIN; TIROFIBAN; TISSUE FACTOR PATHWAY INHIBITOR; UNINDEXED DRUG; WARFARIN;

EID: 84865446716     PISSN: 09575235     EISSN: 14735733     Source Type: Journal    
DOI: 10.1097/MBC.0b013e328355c9cb     Document Type: Review
Times cited : (27)

References (98)
  • 1
    • 79960633202 scopus 로고    scopus 로고
    • Historical perspective and future direction of coagulation research
    • Choi SH, Smith SA, Matsushita T, Kojima T. Historical perspective and future direction of coagulation research. J Thromb Haemost 2011; 9 (Suppl 1): 352-363.
    • (2011) J Thromb Haemost , vol.9 SUPPL. 1 , pp. 352-363
    • Choi, S.H.1    Smith, S.A.2    Matsushita, T.3    Kojima, T.4
  • 2
    • 80051794851 scopus 로고    scopus 로고
    • Factor XI and XII as antithrombotic targets
    • Muller F, Gailani Du , Renne T. Factor XI and XII as antithrombotic targets. Curr Opin Hematol 2011; 18:349-355.
    • (2011) Curr Opin Hematol , vol.18 , pp. 349-355
    • Muller, F.1    Du, G.2    Renne, T.3
  • 5
    • 0031758671 scopus 로고    scopus 로고
    • Heparin and low-molecular-weight heparin: Mechanisms of action, Pharmacokinetics, dosing considerations, monitoring, efficacy, and safety
    • Hirsh J, Warkentin TE, Raschke R, Granger C, Olman EM, Dalen JE. Heparin and low-molecular-weight heparin. Mechanisms of action, pharmacokinetics, dosing considerations, monitoring, efficacy and safety. Chest 1998; 114:489S-510S. (Pubitemid 28535777)
    • (1998) Chest , vol.114 , Issue.5 SUPPL.
    • Hirsh, J.1    Warkentin, T.E.2    Raschke, R.3    Granger, C.4    Ohman, E.M.5    Dalen, J.E.6
  • 6
    • 0017831892 scopus 로고
    • Glycosaminoglycans and their binding to biological macromolecules
    • Lindahl U, Hook M. Glycosaminoglycans and their binding to biological macromolecules. Annu Rev Biochem 1978; 47:385-417.
    • (1978) Annu Rev Biochem , vol.47 , pp. 385-417
    • Lindahl, U.1    Hook, M.2
  • 7
    • 0032135007 scopus 로고    scopus 로고
    • Cardiovascular chemotherapy: Anticoagulants
    • Shafer JA. Cardiovascular chemotherapy: anticoagulants. Curr Opin Chem Biol 1998; 2:458-465. (Pubitemid 128645698)
    • (1998) Current Opinion in Chemical Biology , vol.2 , Issue.4 , pp. 458-465
    • Shafer, J.A.1
  • 8
    • 46149136712 scopus 로고
    • Heparin fractions and analogues: A new therapeutic possibility for thrombosis
    • De Prost D. Heparin fractions and analogues: a new therapeutic possibility for thrombosis. Trends Pharm Sci 1986; 7:496-500.
    • (1986) Trends Pharm Sci , vol.7 , pp. 496-500
    • De Prost, D.1
  • 9
    • 0034667831 scopus 로고    scopus 로고
    • Low molecular weight heparins: Are they superior to unfractionated heparins to prevent and to treat deep vein thrombosis?
    • Boneu B. Low molecular weight heparins: are they superior to unfractionated heparins to prevent and to treat deep vein thrombosis? Thromb Res 2000; 100:V113-V120.
    • (2000) Thromb Res , vol.100
    • Boneu, B.1
  • 10
    • 0034667832 scopus 로고    scopus 로고
    • The role of low-molecular-weight heparins in arterial diseases: Optimizing antithrombotic therapy
    • Cohen M. The role of low-molecular-weight heparins in arterial diseases: optimizing antithrombotic therapy. Thromb Res 2000; 100:V131-V139.
    • (2000) Thromb Res , vol.100
    • Cohen, M.1
  • 11
    • 0027509462 scopus 로고
    • Glycosaminoglycans and the regulation of blood coagulation
    • Bourin M-C, Lindahl U. Glycosaminoglycans and the regulation of blood coagulation. Biochem J 1993; 289:313-330. (Pubitemid 23042035)
    • (1993) Biochemical Journal , vol.289 , Issue.2 , pp. 313-330
    • Bourin, M.1    Lindahl, U.2
  • 12
    • 0022829898 scopus 로고
    • The kinetics of inhibition of α-thrombin in human plasma
    • Jesty J. The kinetics of inhibition of (-thrombin in human plasma. J Biol Chem 1986; 261:10313-10318. (Pubitemid 17221969)
    • (1986) Journal of Biological Chemistry , vol.261 , Issue.22 , pp. 10313-10318
    • Jesty, J.1
  • 13
    • 0022977122 scopus 로고
    • Role of ternary complexes, in which heparin binds both antithrombin and proteinase, in the acceleration of the reactions between antithrombin and thrombin or factor Xa
    • Danielsson A, Raub E, Lindahl U, Bjork I. Role of ternary complexes in which heparin binds both antithrombin and proteinase, in the acceleration of the reactions between antithrombin and thrombin or factor Xa. J Biol Chem 1986; 261:15467-15473. (Pubitemid 17208768)
    • (1986) Journal of Biological Chemistry , vol.261 , Issue.33 , pp. 15467-15473
    • Danielsson, A.1    Raub, E.2    Lindahl, U.3    Bjork, I.4
  • 14
    • 0020395234 scopus 로고
    • Demonstration of a two-step reaction mechanism for inhibition of α-thrombin by antithrombin III and identification of the step affected by heparin
    • Olson ST, Shore JD. Demonstration of a two-step reaction mechanism for inhibition of (-thrombin by antithrombin III and identification of the step affected by heparin. J Biol Chem 1982; 257:14891-14895. (Pubitemid 13159581)
    • (1982) Journal of Biological Chemistry , vol.257 , Issue.24 , pp. 14891-14895
    • Olson, S.T.1    Shore, J.D.2
  • 15
    • 0021061174 scopus 로고
    • Structure-activity relationship in heparin: A synthetic pentasaccharide with high affinity for atithrombin III and eliciting high anti-factor Xa activity
    • Chaoy J, Petitou M, Lormeau JC, Sinay P, Casu B, Gatti G. Structureactivity relationship in hepar: a synthetic pentasaccharide with high affinity for antithrombin III eliciting high antifactor Xa activity. Biochem Biophys Res Commun 1983; 116:492-499. (Pubitemid 14242772)
    • (1983) Biochemical and Biophysical Research Communications , vol.116 , Issue.2 , pp. 492-499
    • Choay, J.1    Petitou, M.2    Lormeau, J.C.3
  • 16
    • 0030657824 scopus 로고    scopus 로고
    • Biochemistry and pharmacology of low molecular weight heparin
    • Rosenberg R. Biochemistry and pharmacology of low molecular weight heparin. Semin Hematol 1997; 34 (Suppl 4):2-8. (Pubitemid 27518238)
    • (1997) Seminars in Hematology , vol.34 , Issue.4 SUPPL. 4 , pp. 2-8
    • Rosenberg, R.D.1
  • 18
    • 0025090942 scopus 로고
    • Risk of myocardial infarction and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery disease
    • DOI 10.1016/0140-6736(90)92336-G
    • Wallentin L, for the RISC group. Risk of myocardial infarction and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery disease. Lancet 1990; 336:827-830. (Pubitemid 20311324)
    • (1990) Lancet , vol.336 , Issue.8719 , pp. 827-830
    • Wallentin, L.1
  • 20
    • 0029771618 scopus 로고    scopus 로고
    • Adding heparin to aspirin reduces the incidence of myocardial infarction and death in patients with unstable angina: A meta-analysis
    • DOI 10.1001/jama.276.10.811
    • Oler A, Whooley MA, Oler J, Grady D. Adding heparin to aspirin reduced the incidence of myocardial infarction and death in patients with unstable angina. A meta-analysis. JAMA 1996; 276:811-815. (Pubitemid 26301581)
    • (1996) Journal of the American Medical Association , vol.276 , Issue.10 , pp. 811-815
    • Oler, A.1    Whooley, M.A.2    Oler, J.3    Grady, D.4
  • 21
    • 0026736119 scopus 로고
    • Reactivation of unstable angina after the discontinuation of heparin
    • Theroux P, Waters D, Lam J, Juneau M, McCans J. Reactivation of unstable angina after the discontinuation of heparin. N Engl J Med 1992; 327:141-145.
    • (1992) N Engl J Med , vol.327 , pp. 141-145
    • Theroux, P.1    Waters, D.2    Lam, J.3    Juneau, M.4    McCans, J.5
  • 22
    • 0032514663 scopus 로고    scopus 로고
    • Low-molecular-weight heparin: A review of the results of recent studies of the treatment of venous thromboembolism and unstable angina
    • Hirsh J. Low-molecular-weight heparin: a review of the results of recent studies of the treatment of venous thromboembolism and unstable angina. Circulation 1998; 98:1575-1582. (Pubitemid 28481675)
    • (1998) Circulation , vol.98 , Issue.15 , pp. 1575-1582
    • Hirsh, J.1
  • 24
    • 0027213684 scopus 로고
    • Comparison of efficacy of low molecular weight heparin (parnaparin) with that of unfractionated heparin in the presence of activated platelets in healthy subjects
    • DOI 10.1016/0002-9149(93)91139-9
    • Melandri G, Semprini F, Cervi V, Candiotti N, Branzi A, Palazzini E, Magnani B. Comparison of efficacy of low molecular weight heparin (parnaparin) with that of unfractionated heparin in the presence of activated platelets in healthy subjects. Am J Cardiol 1993; 72:450-454. (Pubitemid 23238431)
    • (1993) American Journal of Cardiology , vol.72 , Issue.5 , pp. 450-454
    • Melandri, G.1    Semprini, F.2    Cervi, V.3    Candiotti, N.4    Branzi, A.5    Palazzini, E.6    Magnani, B.7
  • 25
    • 0030995712 scopus 로고    scopus 로고
    • Direct thrombin inhibitors in cardiovascular disease
    • Catella-Lawson F. Direct thrombin inhibitors in cardiovascular disease. Coron Artery Dis 1997; 8:105-111. (Pubitemid 27248437)
    • (1997) Coronary Artery Disease , vol.8 , Issue.2 , pp. 105-111
    • Catella-Lawson, F.1
  • 26
    • 0024405893 scopus 로고
    • Unfractionated heparin and CY 216: Pharmacokinetics and bioavailabilities of the antifactor Xa and IIa effects after intravenous and subcutaneous injection in the rabbit
    • Briant L, Caranobe C, Saivin S, Sie P, Bayrou B, Houin G, Boneu B. Unfractionated heparin and CY216: pharmacokinetics and bioavalilabilities of the antifactor Xa and IIa: effects of intravenous and subcutaneous injection in rabbits. Thromb Res 1989; 61:348-353. (Pubitemid 19168134)
    • (1989) Thrombosis and Haemostasis , vol.61 , Issue.3 , pp. 348-353
    • Briant, L.1    Caranobe, C.2    Saivin, S.3    Sie, P.4    Bayrou, B.5    Houin, G.6    Boneu, B.7
  • 28
    • 0000344653 scopus 로고
    • Colman RW, Hirsh J, Marder VJ, Salzman EW, editors. Hemostasis, thrombosis: basic principles, clinical, practice. 2nd ed Philadelphia: JB Lippincott
    • Rosenberg RD. The heparin-antithrombin system: a natural anticoagulant mechanism. In: Colman RW, Hirsh J, Marder VJ, Salzman EW, editors. Hemostasis, thrombosis: basic principles, clinical, practice. 2nd ed. Philadelphia: JB Lippincott; 1987. pp. 1373-1392.
    • (1987) The Heparin-antithrombin System: A Natural Anticoagulant Mechanism , pp. 1373-1392
    • Rosenberg, R.D.1
  • 29
    • 67849083115 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia
    • Greinacher A. Heparin-induced thrombocytopenia. J Thromb Haemost 2009; 7 (Suppl 1):9-12.
    • (2009) J Thromb Haemost , vol.7 SUPPL 1 , pp. 9-12
    • Greinacher, A.1
  • 32
    • 0022402670 scopus 로고
    • Disappearance of circulating anti-Xa activity after intravenous injection of standard heparin and of a low molecular weight heparin (CY 216) in normal and nephrectomized rabbits
    • DOI 10.1016/0049-3848(85)90357-3
    • Caranobe C, Barret A, Gabaig AM, Dupouy D, Sie P, Boneu B. Disappearance of circulating anti-Xa activity after intravenous injection of standard heparin and low molecular weight heparin (CY216) in normal and nephrectomized rabbits. Thromb Res 1985; 40:129-133. (Pubitemid 16204034)
    • (1985) Thrombosis Research , vol.40 , Issue.1 , pp. 129-133
    • Caranobe, C.1    Barret, A.2    Gabaig, A.M.3
  • 33
    • 0023636977 scopus 로고
    • Pharmacokinetics of heparin and low molecular weight heparin fragment (fragmin®) in rabbits with impaired renal or metabolic clearance
    • Palm M, Mattsson CH. Pharmacokinetics of heparin and low molecular weight heparin (fragmin) in rabbits with impaired renal or metabolic clearance. Thromb Haemost 1987; 58:932-935. (Pubitemid 18020466)
    • (1987) Thrombosis and Haemostasis , vol.58 , Issue.3 , pp. 932-935
    • Palm, M.1    Mattsson, Ch.2
  • 35
    • 0029969612 scopus 로고    scopus 로고
    • Treatment of venous thrombosis with intravenous unfractionated heparin administered in the hospital as compared with subcutaneous low-molecular-weight heparin administered at home. The Tasman Study Group
    • Koopman MMW, Prandoni P, Piovella F, Oskelford PA, Brandjes DP, van der Meer J, et al. Treatment of venous thrombosis with intravenous unfractionated heparin administered in the hospital as compared with subcutaneous low-molecular-weight heparin administered at home. The Tasman Study Group. N Engl J Med 1996; 334:682-687.
    • (1996) N Engl J Med , vol.334 , pp. 682-687
    • Mmw, K.1    Prandoni, P.2    Piovella, F.3    Oskelford, P.A.4    Brandjes, D.P.5    Van Der Meer, J.6
  • 36
    • 77957275340 scopus 로고    scopus 로고
    • Warfarin: Indications, risks and drug interactions
    • Tadros R, Shakib S. Warfarin: indications, risks and drug interactions. Aust Fam Physician 2010; 39:476-479.
    • (2010) Aust Fam Physician , vol.39 , pp. 476-479
    • Tadros, R.1    Shakib, S.2
  • 38
    • 79960647787 scopus 로고    scopus 로고
    • Recent progress in anticoagulant therapy: Oral direct inhibitors of thrombin and factor Xa
    • Bauer KA. Recent progress in anticoagulant therapy: oral direct inhibitors of thrombin and factor Xa. J Thromb Haemost 2011; 9 (Suppl 1):12-19.
    • (2011) J Thromb Haemost , vol.9 SUPPL. 1 , pp. 12-19
    • Bauer, K.A.1
  • 40
    • 0028284442 scopus 로고
    • A meta-analysis of methods to prevent venous thromboembolism following total hip replacement
    • DOI 10.1001/jama.271.22.1780
    • Imperiale TF, Speroff T. A meta-analysis of methods to prevent venous thromboembolism following total hip replacement. JAMA 1994; 271:1780-1785. (Pubitemid 24166618)
    • (1994) Journal of the American Medical Association , vol.271 , Issue.22 , pp. 1780-1785
    • Imperiale, T.F.1    Speroff, T.2
  • 44
    • 0029998044 scopus 로고    scopus 로고
    • Potential advantages of direct-acting thrombin inhibitors
    • Philippides GJ, Loscalzo J. Potential advantages of direct-acting thrombin inhibitors. Coron Artery Dis 1996; 7:497-507. (Pubitemid 26365625)
    • (1996) Coronary Artery Disease , vol.7 , Issue.7 , pp. 497-507
    • Philippides, G.J.1    Loscalzo, J.2
  • 45
    • 0028092111 scopus 로고
    • Hirudin in acute myocardial infarction: Safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A trial
    • Antman EM. Hirudin in acute myocardial infarction. Safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A Trial. Circulation 1994; 90:1624-1630. (Pubitemid 24320906)
    • (1994) Circulation , vol.90 , Issue.4 , pp. 1624-1630
    • Antman, E.M.1
  • 46
    • 0028117846 scopus 로고
    • Safety observations from the pilot phase of the randomized r-Hirudin for Improvement of Thrombolysis (HIT-III) study A study of the Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausarzte (ALKK)
    • Neuhaus KL, von Essen R, Tebbe U, Jessel A, Heinrichs H, Maurer W, et al. Safety observations from the pilot phase of the randomized r-Hirudin for Improvement of Thrombolysis (HIT-III) study. A study of the Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausarzte (ALKK). Circulation 1994; 90:1638-1642.
    • (1994) Circulation , vol.90 , pp. 1638-1642
    • Neuhaus, K.L.1    Von Essen, R.2    Tebbe, U.3    Jessel, A.4    Heinrichs, H.5    Maurer, W.6
  • 47
    • 0018973964 scopus 로고
    • Strategies for anticoagulation with synthetic protease inhibitors. Xa inhibitors versus thrombin inhibitors
    • DOI 10.1016/0049-3848(80)90262-5
    • Tidwell RR, Webster WP, Shaver SR, Geratz JD. Strategies for anticoagulation with synthetic protease inhibitors. Xa inhibitors versus thrombin inhibitors. Thromb Res 1980; 19:339-349. (Pubitemid 10029564)
    • (1980) Thrombosis Research , vol.19 , Issue.3 , pp. 339-349
    • Tidwell, R.R.1    Webster, W.P.2    Shaver, S.R.3    Geratz, J.D.4
  • 48
    • 0035383371 scopus 로고    scopus 로고
    • The design of competitive, small-molecule inhibitors of coagulation factor Xa
    • Pauls HW, Ewing WR. The design of competitive, small-molecule inhibitors of coagulation factor Xa. Curr Top Med Chem 2001; 1:83-100.
    • (2001) Curr Top Med Chem , vol.1 , pp. 83-100
    • Pauls, H.W.1    Ewing, W.R.2
  • 50
    • 0028236301 scopus 로고
    • Synthetic peptides and peptidomimetics as substrates and inhibitors of thrombin and other proteases in the blood coagulation system
    • Claeson G. Synthetic peptides and peptidomimetics as substrates and inhibitors of thrombin and other proteases in the blood coagulation system. Blood Coagul Fibrinolysis 1994; 5:411-436. (Pubitemid 24173457)
    • (1994) Blood Coagulation and Fibrinolysis , vol.5 , Issue.3 , pp. 411-436
    • Claeson, G.1
  • 51
    • 0032432971 scopus 로고    scopus 로고
    • Coagulation factor Xa: The prothrombinase complex as an emerging therapeutic target for small molecule inhibitors
    • Scarborough RM. Coagulation factor Xa: the prothrombinase complex as an emerging therapeutic target for small molecule inhibitors. J Enzyme Inhib 1998; 14:15-25. (Pubitemid 29017184)
    • (1998) Journal of Enzyme Inhibition , vol.14 , Issue.1 , pp. 15-25
    • Scarborough, R.M.1
  • 52
    • 0034597606 scopus 로고    scopus 로고
    • Rational design, synthesis and biological activity of benzoxazinones as novel factor Xa inhibitors
    • Dudley DA, Bunker AM, Chi L, Cody WL, Holland DR, Ignasiak DP, et al. Rational design, synthesis and biological activity of benzoxazinones as novel factor Xa inhibitors. J Med Chem 2000; 43:4063-4070.
    • (2000) J Med Chem , vol.43 , pp. 4063-4070
    • Dudley, D.A.1    Bunker, A.M.2    Chi, L.3    Cody, W.L.4    Holland, D.R.5    Ignasiak, D.P.6
  • 53
    • 0022521744 scopus 로고
    • Kinetics of the inhibition of thrombin by hirudin
    • Stone SR, Hofsteenge J. Kinetics of the inhibition of thrombin by hirudin. Biochemistry 1986; 25:4622-4628. (Pubitemid 16010197)
    • (1986) Biochemistry , vol.25 , Issue.16 , pp. 4622-4628
    • Stone, S.R.1    Hofsteenge, J.2
  • 54
    • 0023841705 scopus 로고
    • Interaction of site specific hirudin variants with α-thrombin
    • DOI 10.1016/0014-5793(88)80803-2
    • Dodt J, Kohler S, Baici A. Interaction of site specific hirudin variants with alpha-thrombin. FEBS Lett 1988; 229:87-90. (Pubitemid 18058753)
    • (1988) FEBS Letters , vol.229 , Issue.1 , pp. 87-90
    • Dodt, J.1    Kohler, S.2    Baici, A.3
  • 56
    • 0025866812 scopus 로고
    • Refined structure of the hirudinthrombin complex
    • Rydel TJ, Tulinsky A, Bode W, Huber R. Refined structure of the hirudinthrombin complex. J Mol Biol 1991; 221:583-601.
    • (1991) J Mol Biol , vol.221 , pp. 583-601
    • Rydel, T.J.1    Tulinsky, A.2    Bode, W.3    Huber, R.4
  • 57
    • 0032841949 scopus 로고    scopus 로고
    • Direct thrombin inhibitors: Current status and future prospects
    • DOI 10.1517/13543784.8.9.1373
    • Menear K. Direct thrombin inhibitors: current status and future prospects. Exp Opin Invest Drugs 1999; 8:1373-1384. (Pubitemid 29417621)
    • (1999) Expert Opinion on Investigational Drugs , vol.8 , Issue.9 , pp. 1373-1384
    • Menear, K.1
  • 58
    • 0033832463 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: Recommendation for optimal use of recombinant hirudin
    • Lubenow N, Creinacher A. Heparin-induced thrombocytopenia: recommendation for optimal use of recombinant hirudin. Biodrugs 2000; 14:109-125.
    • (2000) Biodrugs , vol.14 , pp. 109-125
    • Lubenow, N.1    Creinacher, A.2
  • 60
    • 0027959329 scopus 로고
    • Effects of the synthetic thrombin inhibitor argatroban on fibrin- or clot-incorporated thrombin: Comparison with heparin and recombinant hirudin
    • Berry CN, Girardot C, Lecoffre C, Lunven C. Effects of the synthetic thrombin inhibitor agratroban on fibrin- or clot-incorporated thromb: comparison with heparin and recombinant hirudin. Thromb Haemost 1994; 72:381-386. (Pubitemid 24280776)
    • (1994) Thrombosis and Haemostasis , vol.72 , Issue.3 , pp. 381-386
    • Berry, C.N.1    Girardot, C.2    Lecoffre, C.3    Lunven, C.4
  • 61
    • 84875007450 scopus 로고    scopus 로고
    • Wolters Kluwer Health Pharma Solutions (Europe) Limited, accessed 1 June
    • Refludan Product Monograph. 2006. Wolters Kluwer Health Pharma Solutions (Europe) Limited, pp. 44. http://www.bayer.ca/files/REFLUDANPM-ENG-29MAY2007- 113596.pdf (accessed 1 June 2012)
    • (2012) Refludan Product Monograph 2006 , pp. 44
  • 62
    • 0025346345 scopus 로고
    • Design and characterization of hirulogs: A novel class of bivalent peptide inhibitors of thrombin
    • DOI 10.1021/bi00482a021
    • Maraganore JM, Bourdon P, Jablonski J, Ramachandran KL, Fenton JW II. Design and characterization of hirulogs: a novel class of bivalent peptide inhibitors of thrombin. Biochemistry 1990; 29:7095-7101. (Pubitemid 20241158)
    • (1990) Biochemistry , vol.29 , Issue.30 , pp. 7095-7101
    • Maraganore, J.M.1    Bourdon, P.2    Jablonski, J.3    Ramachandran, K.L.4    Fenton II, J.W.5
  • 63
    • 0029065197 scopus 로고
    • Comparative studies on the anticoagulant and protease generation inhibitory actions of newly developed site-directed thrombin inhibitory drugs Efegatran, argatroban, hirulog and hirudin
    • Callas DD, Hoppensteadt D, Fareed J. Comparative studies on the anticoagulant and protease generation inhibitory actions of newly developed site-directed thrombin inhibitory drugs. Efegatran, argatroban, hirulog and hirudin. Semin Thromb Hemost 1995; 21:177-183.
    • (1995) Semin Thromb Hemost , vol.21 , pp. 177-183
    • Callas, D.D.1    Hoppensteadt, D.2    Fareed, J.3
  • 64
    • 0034098236 scopus 로고    scopus 로고
    • Bivalirudin: A new generation antithrombotic drug
    • Scatena R. Bivalirudin: a new generation antithrombotic drugs. Exp Opin Invest Drugs 2000; 9:1119-1127. (Pubitemid 30255571)
    • (2000) Expert Opinion on Investigational Drugs , vol.9 , Issue.5 , pp. 1119-1127
    • Scatena, R.1
  • 66
    • 79955665055 scopus 로고    scopus 로고
    • Oral direct thrombin and factor Xa inhibitors: The replacement for warfarin leeches and pig intestines?
    • Straub A, Roehrig S, Hillisch A. Oral, direct thrombin and factor Xa inhibitors: the replacement for warfarin, leeches, and pig intestines? Angew Chem Int Ed 2011; 50:4574-4590.
    • (2011) Angew Chem Int Ed , vol.50 , pp. 4574-4590
    • Straub, A.1    Roehrig, S.2    Hillisch, A.3
  • 67
    • 32544453399 scopus 로고    scopus 로고
    • New anticoagulants: Anti IIa vs anti Xa - Is one better?
    • DOI 10.1007/s11239-006-5579-4, Proceedings of the Eight National Conference on Anticoagulent Therapy
    • Bauer KA. New anticoagulants: anti IIa vs anti Xa - is one better? J Thromb Thrombolysis 2006; 21:67-72. (Pubitemid 43231131)
    • (2006) Journal of Thrombosis and Thrombolysis , vol.21 , Issue.1 , pp. 67-72
    • Bauer, K.A.1
  • 68
    • 0000780167 scopus 로고    scopus 로고
    • Pifarre R, editor. New anticoagulants for the cardiovascular patient. Philadelphia, Pennsylvania: Hanley and Belfus Inc
    • Schwarz RP. The preclinical and clinical pharmacology of Novastan (argatroban). In: Pifarre R, editor. New anticoagulants for the cardiovascular patient. Philadelphia, Pennsylvania: Hanley and Belfus Inc.; 1997. pp. 231-249.
    • (1997) The Preclinical and Clinical Pharmacology of Novastan (Argatroban) , pp. 231-249
    • Schwarz, R.P.1
  • 69
    • 0019891328 scopus 로고
    • Potent inhibition of thrombin by the newly synthesized arginine derivative no.805 the importance of stereo-structure of its hydrophobic carboxamide portion
    • Okamoto S, Hijikata A, Kikumoto R, Tonomura S, Hara H, Ninomiya K, et al. Potent inhibition of thrombin by the newly synthesized arginine derivative no.805. The importance of stereo-structure of its hydrophobic carboxamide portion. Biochem Biophys Res Commun 1981; 101:440-446.
    • (1981) Biochem Biophys Res Commun , vol.101 , pp. 440-446
    • Okamoto, S.1    Hijikata, A.2    Kikumoto, R.3    Tonomura, S.4    Hara, H.5    Ninomiya, K.6
  • 70
    • 34548031359 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    • DOI 10.1111/j.1365-2125.2007.02899.x
    • Stangier J, Rathgen K, Stahle H, Gansser D, Roth W. The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol 2007; 64:292-303. (Pubitemid 47283865)
    • (2007) British Journal of Clinical Pharmacology , vol.64 , Issue.3 , pp. 292-303
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3    Gansser, D.4    Roth, W.5
  • 72
    • 19344361965 scopus 로고    scopus 로고
    • New anticoagulants and their potential impact on the treatment of thromboembolic disease
    • Ansell J. New anticoagulants and their potential impact on the treatment of thromboembolic disease. Curr Hematol Rep 2004; 3:357-362.
    • (2004) Curr Hematol Rep , vol.3 , pp. 357-362
    • Ansell, J.1
  • 73
    • 0037048227 scopus 로고    scopus 로고
    • For the Steering Committees of the Pentasaccharide Orthopedic Prophylaxis Studies Fondaparinux vs enoxaparin for the prevention of venous thromboembolism in major orthopedic surgery
    • Turpie AGG, Bauer KA, Eriksson BI, Lassen MR, for the Steering Committees of the Pentasaccharide Orthopedic Prophylaxis Studies. Fondaparinux vs enoxaparin for the prevention of venous thromboembolism in major orthopedic surgery. Arch Intern Med 2002; 162:1833-1840.
    • (2002) Arch Intern Med , vol.162 , pp. 1833-1840
    • Agg, T.1    Bauer, K.A.2    Eriksson, B.I.3    Lassen, M.R.4
  • 75
    • 78650932475 scopus 로고    scopus 로고
    • Role of orally available antagonists of factor Xa in the treatment and prevention of thromboembolic disease: Focus on rivaroxaban
    • Morell J, Sullivan B, Khalabuda M, McBride BF. Role of orally available antagonists of factor Xa in the treatment and prevention of thromboembolic disease: focus on rivaroxaban. J Clin Pharmacol 2010; 50:986-1000.
    • (2010) J Clin Pharmacol , vol.50 , pp. 986-1000
    • Morell, J.1    Sullivan, B.2    Khalabuda, M.3    McBride, B.F.4
  • 78
    • 79952062775 scopus 로고    scopus 로고
    • Argatroban in the management of heparin-induced thrombocytopenia
    • Babuin L, Pengo V. Argatroban in the management of heparin-induced thrombocytopenia. Vasc Health Risk Manag 2010; 6:813-819.
    • (2010) Vasc Health Risk Manag , vol.6 , pp. 813-819
    • Babuin, L.1    Pengo, V.2
  • 80
    • 79955817183 scopus 로고    scopus 로고
    • Anticoagulation with argatroban for elective percutaneous coronary intervention: Population pharmacokinetics and pharmacokineticpharmacodynamic relationship of coagulation parameters
    • Akimoto K, Klinkhardt U, Zeiher A, Niethammer M, Harder S. Anticoagulation with argatroban for elective percutaneous coronary intervention: population pharmacokinetics and pharmacokineticpharmacodynamic relationship of coagulation parameters. J Clin Pharmacol 2011; 51:805-818.
    • (2011) J Clin Pharmacol , vol.51 , pp. 805-818
    • Akimoto, K.1    Klinkhardt, U.2    Zeiher, A.3    Niethammer, M.4    Harder, S.5
  • 82
    • 79955023407 scopus 로고    scopus 로고
    • Warfarin versus new agents: Interpreting the data
    • Ansell J. Warfarin versus new agents: interpreting the data. Hematology Am Soc Hematol Educ Program 2010; 2010:221-228.
    • (2010) Hematology Am Soc Hematol Educ Program , vol.2010 , pp. 221-228
    • Ansell, J.1
  • 83
    • 77953168824 scopus 로고    scopus 로고
    • Dabigatran etexilate: A novel reversible, oral direct thrombin inhibitor - Interpretation of coagulation assays and reversal of anticoagulant activity
    • van Ryn J, Stangier J, Haertter S, Liesenfeld K, Hienen W, Feuring M, Clemens A. Dabigatran etexilate: a novel reversible, oral direct thrombin inhibitor - interpretation of coagulation assays and reversal of anticoagulant activity. Thromb Haemost 2010; 103:1116-1127.
    • (2010) Thromb Haemost , vol.103 , pp. 1116-1127
    • Van Ryn, J.1    Stangier, J.2    Haertter, S.3    Liesenfeld, K.4    Hienen, W.5    Feuring, M.6    Clemens, A.7
  • 84
    • 74949139434 scopus 로고    scopus 로고
    • The new oral anticoagulants
    • Garcia D, Libby E, Crowther MA. The new oral anticoagulants. Blood 2010; 115:15-20.
    • (2010) Blood , vol.115 , pp. 15-20
    • Garcia, D.1    Libby, E.2    Crowther, M.A.3
  • 86
    • 2542424669 scopus 로고    scopus 로고
    • Matisse Investigators Fondaparinux or enoxaparin for the initial treatment of symptomatic deep venous thrombosis: A randomized trial
    • Buller HR, Davidson BL, Decousus H, Gallus A, Gent M, Piovella F, et al., Matisse Investigators. Fondaparinux or enoxaparin for the initial treatment of symptomatic deep venous thrombosis: a randomized trial. Ann Intern Med 2004; 140:867-873.
    • (2004) Ann Intern Med , vol.140 , pp. 867-873
    • Buller, H.R.1    Davidson, B.L.2    Decousus, H.3    Gallus, A.4    Gent, M.5    Piovella, F.6
  • 88
    • 34147147009 scopus 로고    scopus 로고
    • On behalf of the Van Gogh Investigators Once weekly subcutaneous idraparinux versus placebo in the extended treatment of deep-vein thrombosis or pulmonary embolism
    • abstract 571
    • Buller HR. On behalf of the Van Gogh Investigators. Once weekly subcutaneous idraparinux versus placebo in the extended treatment of deep-vein thrombosis or pulmonary embolism. Blood 2006; 108:abstract 571.
    • (2006) Blood , vol.108
    • Buller, H.R.1
  • 89
    • 77649113258 scopus 로고    scopus 로고
    • ADVANCE-2 Investigators Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): A randomized double-blind trial
    • Lassen MR, Raskob GE, Gallus A, Pineo G, Chen D, Hornick P, ADVANCE-2 Investigators. Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): a randomized double-blind trial. Lancet 2010; 375:807-815.
    • (2010) Lancet , vol.375 , pp. 807-815
    • Lassen, M.R.1    Raskob, G.E.2    Gallus, A.3    Pineo, G.4    Chen, D.5    Hornick, P.6
  • 90
    • 78650587760 scopus 로고    scopus 로고
    • ADVANCE-3 Investigators Apixaban versus enoxaparin for thromboprophylaxis after hip replacement
    • Lassen MR, Gallus A, Raskob GE, Pineo G, Chen D, Ramirez LM, ADVANCE-3 Investigators. Apixaban versus enoxaparin for thromboprophylaxis after hip replacement. N Engl J Med 2010; 363:2487-2498.
    • (2010) N Engl J Med , vol.363 , pp. 2487-2498
    • Lassen, M.R.1    Gallus, A.2    Raskob, G.E.3    Pineo, G.4    Chen, D.5    Ramirez, L.M.6
  • 91
    • 36349012420 scopus 로고    scopus 로고
    • Intrinsic pathway of coagulation and arterial thrombosis
    • DOI 10.1161/ATVBAHA.107.155952
    • Gailani D, Renne T. Intrinsic pathway of coagulation and arterial thrombosis. Arterioscler Thromb Vasc Biol 2007; 27:2507-2513. (Pubitemid 350158899)
    • (2007) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.27 , Issue.12 , pp. 2507-2513
    • Gailani, D.1    Renne, T.2
  • 92
    • 71149116751 scopus 로고    scopus 로고
    • Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo
    • Muller F, Mutch NJ, Schenk WA, Smith SA, Esterl L, Spronk HM, et al. Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo. Cell 2009; 139:1143-1156.
    • (2009) Cell , vol.139 , pp. 1143-1156
    • Muller, F.1    Mutch, N.J.2    Schenk, W.A.3    Smith, S.A.4    Esterl, L.5    Spronk, H.M.6
  • 93
    • 84255201932 scopus 로고    scopus 로고
    • Polyphosphate is a cofactor for the activation of factor XI by thrombin
    • Choi SH, Smith SA, Morrissey JH. Polyphosphate is a cofactor for the activation of factor XI by thrombin. Blood 2011; 118:6963-6970
    • (2011) Blood , vol.118 , pp. 6963-6970
    • Choi, S.H.1    Smith, S.A.2    Morrissey, J.H.3
  • 97
    • 33751014883 scopus 로고    scopus 로고
    • Basic aspects of bypassing agents
    • Negrier C, Dargaud Y, Bordet JC. Basic aspects of bypassing agents. Haemophilia 2006; 12 (Suppl 6):48-52.
    • (2006) Haemophilia , vol.12 SUPPL. 6 , pp. 48-52
    • Negrier, C.1    Dargaud, Y.2    Bordet, J.C.3
  • 98
    • 77950899732 scopus 로고    scopus 로고
    • Factor XIIa inhibitor recombinant human albumin infestin-4 abolishes occlusive arterial thrombus formation without affecting bleeding
    • Hagedorn I, Schmidbauer S, Pleines I, Kleinschnitz C, Kronthaler U, Stoll G, et al. Factor XIIa inhibitor recombinant human albumin infestin-4 abolishes occlusive arterial thrombus formation without affecting bleeding. Circulation 2010; 121:1510-1517.
    • (2010) Circulation , vol.121 , pp. 1510-1517
    • Hagedorn, I.1    Schmidbauer, S.2    Pleines, I.3    Kleinschnitz, C.4    Kronthaler, U.5    Stoll, G.6


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