Itga2b Regulation at the Onset of Definitive Hematopoiesis and Commitment to Differentiation

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Dumon, Stephanie ^a   Walton, David S ^a   Volpe, Giacomo ^a   Wilson, Nicola ^b   Dassé, Emilie ^a   Del Pozzo, Walter ^d   Landry, Josette Renee ^c   Turner, Bryan ^a   O'Neill, Laura P ^a   Göttgens, Berthold ^b   Frampton, Jon ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^d NIKHEF   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRINOGEN RECEPTOR; HISTONE DEMETHYLASE; HISTONE H3; HISTONE H4; THROMBOPOIETIN RECEPTOR;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CORRELATION ANALYSIS; GENE; GENE LOCUS; GENETIC REGULATION; HEMATOPOIESIS; ITGA2B GENE; MEGAKARYOCYTE; MOUSE; MPL GENE; MULTIPOTENT STEM CELL; NONHUMAN; PROTEIN EXPRESSION; UPREGULATION;

CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; CHROMATIN IMMUNOPRECIPITATION; CLUSTER ANALYSIS; DNA; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; HEMATOPOIESIS; HUMANS; INTEGRIN ALPHA2; MEGAKARYOCYTES; MODELS, GENETIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; PLATELET MEMBRANE GLYCOPROTEIN IIB; PROMOTER REGIONS, GENETIC; RECEPTORS, THROMBOPOIETIN; RECOMBINANT PROTEINS;

EID: 84865445654     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043300     Document Type: Article

References (44)

1. Shogren-Knaak M, Ishii H, Sun JM, Pazin MJ, Davie JR, et al. (2006) Histone H4-K16 acetylation controls chromatin structure and protein interactions. Science 311: 844-847.
2. Sims RJ 3rd, Nishioka K, Reinberg D (2003) Histone lysine methylation: a signature for chromatin function. Trends Genet 19: 629-639.
3. Bannister AJ, Kouzarides T, (2005) Reversing histone methylation. Nature 436: 1103-1106.
4. Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, et al. (2006) A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125: 315-326.
5. Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, et al. (2006) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome Res 16: 55-65.
6. Vincent A, Van Seuningen I, (2009) Epigenetics, stem cells and epithelial cell fate. Differentiation 78: 99-107.
7. Emambokus NR, Frampton J, (2003) The glycoprotein IIb molecule is expressed on early murine hematopoietic progenitors and regulates their numbers in sites of hematopoiesis. Immunity 19: 33-45.
8. Mikkola HK, Fujiwara Y, Schlaeger TM, Traver D, Orkin SH, (2003) Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood 101: 508-516.
9. Ferkowicz MJ, Starr M, Xie X, Li W, Johnson SA, et al. (2003) CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. Development 130: 4393-4403.
10. Eilken HM, Nishikawa S, Schroeder T, (2009) Continuous single-cell imaging of blood generation from haemogenic endothelium. Nature 457: 896-900.
11. Lancrin C, Sroczynska P, Stephenson C, Allen T, Kouskoff V, et al. (2009) The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage. Nature 457: 892-895.
12. Celniker SE, Dillon LA, Gerstein MB, Gunsalus KC, Henikoff S, et al. (2009) Unlocking the secrets of the genome. Nature 459: 927-930.
13. Pinto do OP, Kolterud A, Carlsson L, (1998) Expression of the LIM-homeobox gene LH2 generates immortalized steel factor-dependent multipotent hematopoietic precursors. EMBO J 17: 5744-5756.
14. Pinto do OP, Richter K, Carlsson L, (2002) Hematopoietic progenitor/stem cells immortalized by Lhx2 generate functional hematopoietic cells in vivo. Blood 99: 3939-3946.
15. Ninos JM, Jefferies LC, Cogle CR, Kerr WG, (2006) The thrombopoietin receptor, c-Mpl, is a selective surface marker for human hematopoietic stem cells. J Transl Med 4: 9.
16. Perlingeiro RC, Kyba M, Bodie S, Daley GQ, (2003) A role for thrombopoietin in hemangioblast development. Stem Cells 21: 272-280.
17. Tober J, Koniski A, McGrath KE, Vemishetti R, Emerson R, et al. (2007) The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis. Blood 109: 1433-1441.
18. Huang H, Cantor AB, (2009) Common features of megakaryocytes and hematopoietic stem cells: what's the connection? J Cell Biochem 107: 857-864.
19. Petit-Cocault L, Volle-Challier C, Fleury M, Peault B, Souyri M, (2007) Dual role of Mpl receptor during the establishment of definitive hematopoiesis. Development 134: 3031-3040.
20. Fleury M, Petit-Cocault L, Clay D, Souyri M, (2010) Mpl receptor defect leads to earlier appearance of hematopoietic cells/hematopoietic stem cells in the Aorta-Gonad-Mesonephros region, with increased apoptosis. Int J Dev Biol 54: 1067-1074.
21. Dumon S, Heath VL, Tomlinson MG, Gottgens B, Frampton J, (2006) Differentiation of murine committed megakaryocytic progenitors isolated by a novel strategy reveals the complexity of GATA and Ets factor involvement in megakaryocytopoiesis and an unexpected potential role for GATA-6. Exp Hematol 34: 654-663.
22. Baek D, Davis C, Ewing B, Gordon D, Green P, (2007) Characterization and predictive discovery of evolutionarily conserved mammalian alternative promoters. Genome Res 17: 145-155.
23. Cooper SJ, Trinklein ND, Anton ED, Nguyen L, Myers RM, (2006) Comprehensive analysis of transcriptional promoter structure and function in 1% of the human genome. Genome Res 16: 1-10.
24. Davuluri RV, Suzuki Y, Sugano S, Plass C, Huang TH, (2008) The functional consequences of alternative promoter use in mammalian genomes. Trends Genet 24: 167-177.
25. Levanon D, Groner Y, (2004) Structure and regulated expression of mammalian RUNX genes. Oncogene 23: 4211-4219.
26. Pozner A, Lotem J, Xiao C, Goldenberg D, Brenner O, et al. (2007) Developmentally regulated promoter-switch transcriptionally controls Runx1 function during embryonic hematopoiesis. BMC Dev Biol 7: 84.
27. Jackers P, Szalai G, Moussa O, Watson DK, (2004) Ets-dependent regulation of target gene expression during megakaryopoiesis. Journal of Biological Chemistry 279: 52183-52190.
28. Verdone L, Agricola E, Caserta M, Di Mauro E, (2006) Histone acetylation in gene regulation. Brief Funct Genomic Proteomic 5: 209-221.
29. Asano Y, Trojanowska M, (2009) Phosphorylation of Fli1 at threonine 312 by protein kinase C delta promotes its interaction with p300/CREB-binding protein-associated factor and subsequent acetylation in response to transforming growth factor beta. Mol Cell Biol 29: 1882-1894.
30. Hong W, Kim AY, Ky S, Rakowski C, Seo SB, et al. (2002) Inhibition of CBP-mediated protein acetylation by the Ets family oncoprotein PU.1. Mol Cell Biol 22: 3729-3743.
31. Hayakawa F, Towatari M, Ozawa Y, Tomita A, Privalsky ML, et al. (2004) Functional regulation of GATA-2 by acetylation. J Leukoc Biol 75: 529-540.
32. Letting DL, Rakowski C, Weiss MJ, Blobel GA, (2003) Formation of a tissue-specific histone acetylation pattern by the hematopoietic transcription factor GATA-1. Mol Cell Biol 23: 1334-1340.
33. De Santa F, Totaro MG, Prosperini E, Notarbartolo S, Testa G, et al. (2007) The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell 130: 1083-1094.
34. Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, et al. (2006) Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 441: 349-353.
35. Jepsen K, Solum D, Zhou T, McEvilly RJ, Kim HJ, et al. (2007) SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature 450: 415-419.
36. Burgold T, Spreafico F, De Santa F, Totaro MG, Prosperini E, et al. (2008) The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment. PLoS One 3: e3034.
37. Sen GL, Webster DE, Barragan DI, Chang HY, Khavari PA, (2008) Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3. Genes Dev 22: 1865-1870.
38. De Santa F, Narang V, Yap ZH, Tusi BK, Burgold T, et al. (2009) Jmjd3 contributes to the control of gene expression in LPS-activated macrophages. EMBO J 28: 3341-3352.
39. Garcia P, Cales C, (1996) Endoreplication in megakaryoblastic cell lines is accompanied by sustained expression of G1/S cyclins and downregulation of cdc25C. Oncogene 13: 695-703.
40. Lorvellec M, Dumon S, Maya-Mendoza A, Jackson D, Frampton J, et al. (2010) B-Myb is critical for proper DNA duplication during an unperturbed S phase in mouse embryonic stem cells. Stem Cells 28: 1751-1759.
41. White DA, Belyaev ND, Turner BM, (1999) Preparation of site-specific antibodies to acetylated histones. Methods 19: 417-424.
42. Follows GA, Dhami P, Gottgens B, Bruce AW, Campbell PJ, et al. (2006) Identifying gene regulatory elements by genomic microarray mapping of DNaseI hypersensitive sites. Genome Res 16: 1310-1319.
43. Wingender E, Chen X, Hehl R, Karas H, Liebich I, et al. (2000) TRANSFAC: an integrated system for gene expression regulation. Nucleic Acids Res 28: 316-319.
44. Frith MC, Hansen U, Weng Z, (2001) Detection of cis-element clusters in higher eukaryotic DNA. Bioinformatics 17: 878-889.