Novel mechanism for fluoroquinolone resistance in Acinetobacter baumannii

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 9, 2012, Pages 4955-4957

  Saroj, Sunil D ^a   Clemmer, Katy M ^b   Bonomo, Robert A ^c,d   Rather, Philip N ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ATLANTA VA MEDICAL CENTER   (United States)

^c LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; CHLORAMPHENICOL; CIPROFLOXACIN; EXONUCLEASE; GATIFLOXACIN; GENTAMICIN; OFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFAMPICIN; TIGECYCLINE;

ACINETOBACTER INFECTION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; CONTROLLED STUDY; GENE FUNCTION; GENE INSERTION; GENE MUTATION; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC CODE; NONHUMAN; NULL ALLELE; OPEN READING FRAME; OPERON; PHENOTYPE; PRIORITY JOURNAL; TRANSPOSON; WILD TYPE;

ACINETOBACTER BAUMANNII; DNA TRANSPOSABLE ELEMENTS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; EXODEOXYRIBONUCLEASE V; FLUOROQUINOLONES; GENE EXPRESSION; GENE LIBRARY; GENES, BACTERIAL; GENETIC ENGINEERING; MICROBIAL SENSITIVITY TESTS; MUTATION; OPEN READING FRAMES; PROTEIN SUBUNITS;

EID: 84865429510     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00739-12     Document Type: Article

References (19)

1. Baba T, et al. 2006. Construction of Escherichia coli K-12 in-frame single gene knockout mutants: the Keio collection. Mol. Syst. Biol. 2:2006.0008. doi:10.1038/msb4100050.
2. Bergogne-Bérézin E, Towner KJ. 1996. Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features. Clin. Microbiol. Rev. 9:148-165. (Pubitemid 26123943)
3. Dijkshoorn L, Nemec A, Seifert H. 2007. An increasing threat in hospitals: multidrug resistant Acinetobacter baumannii. Nat. Rev. Microbiol. 5:939-951. (Pubitemid 350131182)
4. Dillingham MS, Kowalczykowski SC. 2008. RecBCD enzyme and the repair of double strandedDNAbreaks. Microbiol. Mol. Biol. Rev. 72:642-671.
5. Farinha MA, Kropinski AM. 1990. Construction of broad host range plasmid vectors for easy visible selection and analysis of promoters. J. Bacteriol. 172:3496-3499. (Pubitemid 20179813)
6. Gomez MJ, Neyfakh AA. 2006. Genes involved in intrinsic antibiotic resistance in Acinetobacter baylyi. Antimicrob. Agents Chemother. 50:3562-3567. (Pubitemid 44684866)
7. Gootz TD, Marra A. 2008. Acinetobacter baumannii: an emerging multidrug resistant threat. Exp. Rev. Anti Infect. Ther. 6:309-325.
8. Hujer KM, et al. 2006. Analysis of antibiotic resistance genes in multidrug resistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center. Antimicrob. Agents Chemother. 50:4114-4123. (Pubitemid 44865156)
9. Hunger M, Schmucker R, Kishan V, Hillen W. 1990. Analysis and nucleotide sequence of an origin of DNA replication in Acinetobacter calcoaceticus and its use for Escherichia coli shuttle plasmids. Gene 87:45-51. (Pubitemid 20139853)
10. Joly-Guillou ML. 2005. Clinical impact and pathogenicity of Acinetobacter. Clin. Microbiol. Infect. 11:868-873.
11. Kaniga K, Delor I, Cornelis GR. 1991. A wide host range suicide vector for improving reverse genetics in gram-negative bacteria: inactivation of the blaA gene of Yersinia enterocolitica. Gene 109:137-141.
12. Keen EF, et al. 2010. Changes in the incidence of multidrug resistant and extensively drug resistant organisms isolated in a military care center. Infect. Control Hosp. Epidemiol. 31:728-732.
13. Livermore DM. 2003. The threat from the pink corner. Ann. Med. 35:226-234. (Pubitemid 36791689)
14. Lopez E, Elez M, Matic I, Blazquez J. 2007. Antibiotic mediated recombination: ciprofloxacin stimulates SOS independent recombination of divergent sequences in Escherichia coli. Mol. Microbiol. 64:83-93. (Pubitemid 46435037)
15. Murray CK, Hospenthal DR. 2005. Treatment of multidrug resistant Acinetobacter. Curr. Opin. Infect. Dis. 18:502-506. (Pubitemid 41634762)
16. Peleg AY, Seifert H, Paterson DL. 2008. Acinetobacter baumannii: emergence of a successful pathogen Clin. Microbiol. Rev. 21:538-582.
17. Perez F, et al. 2007. Global challenge of multidrug resistant Acinetobacter baumannii. Antimicrob. Agents Chemother. 51:3471-3484. (Pubitemid 47519332)
18. Rice LB. 2006. Challenges in identifying new antimicrobial agents effective for treating infections with Acinetobacter baumannii and Pseudomonas aeruginosa. Clin. Infect. Dis. 43(Suppl 2):S100-S105. (Pubitemid 44267148)
19. Smith MG, et al. 2007. New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis. Genes Dev. 21:601-614. (Pubitemid 46409474)