Impaired propulsive motility in the distal but not proximal colon of BK channel β1-subunit knockout mice

Neurogastroenterology and Motility

Volumn 24, Issue 9, 2012, Pages

  France, M ^a   Bhattarai, Y ^a   Galligan, J J ^a,b   Xu, H ^a,b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Colonic motility; Constipation; Potassium channels

Indexed keywords

BETHANECHOL; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL BETA SUBUNIT; NEUROTRANSMITTER; NIFEDIPINE; PAXILLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCENDING COLON; CELL MEMBRANE DEPOLARIZATION; CHOLINERGIC ACTIVITY; CHOLINERGIC TRANSMISSION; COLON MOTILITY; CONSTIPATION; CONTROLLED STUDY; FECES; HYPERPOLARIZATION; IN VITRO STUDY; IN VIVO STUDY; INTESTINAL DYSMOTILITY; INTESTINE INNERVATION; INTESTINE TRANSIT TIME; KNOCKOUT MOUSE; MICROELECTRODE; MOUSE; MUSCLE ACTION POTENTIAL; MUSCLE CONTRACTION; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; STOMACH EMPTYING;

ANIMALS; COLON; CONSTIPATION; GASTROINTESTINAL MOTILITY; INTESTINE, SMALL; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL BETA SUBUNITS; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE;

EID: 84865426804     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2012.01981.x     Document Type: Article

References (30)

1. Salkoff L, Butler A, Ferreira G, Santi C, Wei A. High-conductance potassium channels of the SLO family. Nat Rev Neurosci 2006; 7: 921-31.
2. Tricarico D, Mele A, Conte Camerino D. Phenotype-dependent functional and pharmacological properties of BK channels in skeletal muscle: effects of microgravity. Neurobiol Dis 2005; 20: 296-302.
3. + channel alpha-subunits in mouse cardiomyocytes. Biochem Biophys Res Commun 2009; 389: 74-9.
4. 2+-sensitive ion channels. Cell Calcium 2003; 34: 211-29.
5. Essin K, Gollasch M, Rolle S et al. BK channels in innate immune functions of neutrophils and macrophages. Blood 2009; 113: 1326-31.
6. 2+-activated (BK) channel. J Physiol 2010; 588: 3141-8.
7. 2+ binding to the BKCa channel. J Gen Physiol 2009; 133: 139-50.
8. + channel from smooth muscle. J Biol Chem 1994; 269: 17274-8.
9. Garcia-Calvo M, Knaus HG, McManus OB, Giangiacomo KM, Kaczorowski GJ, Garcia ML. Purification and reconstitution of the high-conductance, calcium-activated potassium channel from tracheal smooth muscle. J Biol Chem 1994; 269: 676-82.
10. Semenov I, Wang B, Herlihy JT, Brenner R. BK channel β1 subunits regulate airway contraction secondary to M2 muscarinic acetylcholine receptor mediated depolarization. J Physiol 2011; 589: 1803-17.
11. Xu H, Kandlikar SS, Westcott EB, Fink GD, Galligan JJ. Requirement for functional BK channels in maintaining oscillation in venomotor tone revealed by species differences in expression of the beta1 accessory subunits. J Cardiovasc Pharmacol 2012; 59: 29-36.
12. Brenner R, Peréz GJ, Bonev AD et al. Vasoregulation by the beta1 subunit of the calcium-activated potassium channel. Nature 2000; 407: 870-6.
13. Petkov GV, Bonev AD, Heppner TJ, Brenner R, Aldrich RW, Nelson MT. Beta1-subunit of the Ca2+-activated K+ channel regulates contractile activity of mouse urinary bladder smooth muscle. J Physiol 2001; 537: 443-52.
14. Vandael DH, Marcantoni A, Mahapatra S et al. Ca(v)1.3 and BK channels for timing and regulating cell firing. Mol Neurobiol 2010; 42: 185-98.
15. 2+ transients and distribution of BK channels and ryanodine receptors in smooth muscle cells of guinea-pig vas deferens and urinary bladder. J Physiol 2001; 534: 313-26.
16. Semenov I, Wang B, Herlihy JT, Brenner R. BK channel β1-subunit regulation of calcium handling and constriction in tracheal smooth muscle. Am J Physiol 2006; 291: L802-10.
17. + (BK) channels by protein kinase C. Am J Physiol 2003; 285: C1270-80.
18. Xu H, Wang Y, Garver H, Galligan JJ, Fink GD. Vascular BK channel deficiency exacerbates organ damage and mortality in endotoxemic mice. J Cardiovasc Pharmacol 2012; 59: 207-14.
19. + channel beta1-subunit knockout mice are not hypertensive. Am J Physiol 2011; 300: H476-85.
20. Devries MP, Vessalo M, Galligan JJ. Deletion of P2X2 and P2X3 receptor subunits does not alter motility of the mouse colon. Front Neurosci 2010; 4: 1-7.
21. Raffa RB, Mathiasen JR, Jacoby HI. Colonic bead expulsion time in normal and mu-opioid receptor deficient (CXBK) mice following central (ICV) administration of mu- and delta-opioid agonists. Life Sci 1987; 41: 2229-34.
22. Miller MS, Galligan JJ, Burks TF. Accurate measurement of intestinal transit in the rat. J Pharmacol Methods 1981; 6: 211-7.
23. Stengel A, Goebel-Stengel M, Wang L, Larauche M, Rivier J, Taché Y. Central somatostatin receptor 1 activation reverses acute stress-related alterations of gastric and colonic motor function in mice. Neurogastroenterol Motil 2011; 23: e223-36.
24. Fichna J, Dicay M, Hirota SA et al. Differential effects of salvinorin A on endotoxin-induced hypermotility and neurogenic ion transport in mouse ileum. Neurogastroenterol Motil 2011; 23: 583-e212.
25. Hoogerwerf WA, Shahinian VB, Cornélissen G et al. Rhythmic changes in colonic motility are regulated by period genes. Am J Physiol 2010; 298: G143-50.
26. Gourcerol G, Wang L, Adelson DW, Larauche M, Taché Y, Million M. Cholinergic giant migrating contractions in conscious mouse colon assessed by using a novel noninvasive solid-state manometry method: modulation by stressors. Am J Physiol 2009; 296: G992-1002.
27. Kashyap P, Gomez-Pinilla PJ, Pozo MJ et al. Immunoreactivity for Ano1 detects depletion of Kit-positive interstitial cells of Cajal in patients with slow transit constipation. Neurogastroenterol Motil 2011; 23: 760-5.
28. Knowles CH, Farrugia G. Gastrointestinal neuromuscular pathology in chronic constipation. Best Pract Res Clin Gastroenterol 2011; 25: 43-57.
29. Dinning PG, Zarate N, Hunt LM et al. Pancolonic spatiotemporal mapping reveals regional deficiencies in, and disorganization of colonic propagating pressure waves in severe constipation. Neurogastroenterol Motil 2010; 22: e340-9.
30. King SK, Sutcliffe JR, Ong SY et al. Substance P and vasoactive intestinal peptide are reduced in right transverse colon in pediatric slow-transit constipation. Neurogastroenterol Motil 2010; 22: 883-e234.