Effects of methylnaltrexone in patients with narcotic bowel syndrome: A pilot observational study

Internal Medicine Journal

Volumn 42, Issue 8, 2012, Pages 907-912

  Gibson, P R ^a   Morrison, G ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

opioid antagonist; opioid receptors; Abdominal pain; Constipation; Fatigue; Opiate

Indexed keywords

17 METHYLNALTREXONE; METHADONE; MORPHINE; MU OPIATE RECEPTOR; PETHIDINE; TRAMADOL;

ABDOMINAL DISTENSION; ABDOMINAL PAIN; ADULT; ARTICLE; BLOATING; CASE REPORT; CHRONIC PAIN; DISEASE SEVERITY; DRUG DOSE ESCALATION; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; ENTEROPATHY; FATIGUE; FEMALE; FUNCTIONAL ASSESSMENT OF CHRONIC ILLNESSES THERAPY FATIGUE QUESTIONNAIRE; HUMAN; ILEOSTOMY; INTESTINE FUNCTION; NARCOTIC BOWEL SYNDROME; NAUSEA; OBSERVATIONAL STUDY; PATIENT COMPLIANCE; PATIENT SATISFACTION; PILOT STUDY; PRIORITY JOURNAL; QUESTIONNAIRE; RECEPTOR BLOCKING; RECTAL PAIN; SYMPTOMATOLOGY; TREATMENT DURATION; TREATMENT RESPONSE; VISUAL ANALOG SCALE; VOMITING;

ABDOMINAL PAIN; ADULT; FEMALE; HUMANS; MIDDLE AGED; NALTREXONE; NARCOTIC ANTAGONISTS; NARCOTICS; PILOT PROJECTS; PROSPECTIVE STUDIES; QUATERNARY AMMONIUM COMPOUNDS; SYNDROME; TREATMENT OUTCOME;

EID: 84865400328     PISSN: 14440903     EISSN: 14455994     Source Type: Journal    
DOI: 10.1111/j.1445-5994.2012.02726.x     Document Type: Article

References (10)

1. Grunkemeier DM, Cassara JE, Dalton CB, Drossman DA. The narcotic bowel syndrome: clinical features, pathophysiology, and management. Clin Gastroenterol Hepatol 2007; 5: 1126-39.
2. Choung RS, Locke GR 3rd, Zinsmeister AR, Schleck CD, Talley NJ. Opioid bowel dysfunction and narcotic bowel syndrome: a population-based study. Am J Gastroenterol 2009; 104: 1199-204.
3. Tuteja AK, Biskupiak J, Stoddard GJ, Lipman AG. Opioid-induced bowel disorders and narcotic bowel syndrome in patients with chronic non-cancer pain. Neurogastroenterol Motil 2010; 22: 424-30.
4. Agostini S, Eutamene H, Cartier C, Broccardo M, Improta G, Houdeau E etal. Evidence of central and peripheral sensitization in a rat model of narcotic bowel-like syndrome. Gastroenterology 2010; 139: 553-63.
5. Gibson PR, Shepherd SJ. Evidence-based dietary management of functional gastrointestinal disorders. The FODMAP approach. J Gastroenterol Hepatol 2010; 25: 252-8.
6. McNicol E, Boyce DB, Schumann R, Carr D. Efficacy and safety of mu-opioid antagonists in the treatment of opioid-induced bowel dysfunction: systematic review and meta-analysis of randomized controlled trials. Pain Med 2008; 9: 634-59.
7. Candy B, Jones L, Goodman ML, Drake R, Tookman A. Laxatives or methylnaltrexone for the management of constipation in palliative care patients. Cochrane Database Syst Rev 2011; (1): CD003448.
8. Cella D, Yount S, Sorensen M, Chartash E, Sengupta N, Grober J. Validation of the Functional Assessment of Chronic Illness Therapy Fatigue Scale relative to other instrumentation in patients with rheumatoid arthritis. J Rheumatol 2005; 32: 811-19.
9. Rotshteyn Y, Boyd TA, Yuan CS. Methylnaltrexone bromide: research update of pharmacokinetics following parenteral administration. Expert Opin Drug Metab Toxicol 2011; 7: 227-35.
10. Thomas J, Karver S, Cooney GA, Chamberlain BH, Watt CK, Slatkin NE etal. Methylnaltrexone for opioid-induced constipation in advanced illness. N Engl J Med 2008; 358: 2332-43.