High levels of β2-adrenoceptors are expressed in infantile capillary hemangiomas and may mediate the therapeutic effect of propranolol

Journal of Cutaneous Pathology

Volumn 39, Issue 9, 2012, Pages 881-883

  Hadaschik, Eva ^a   Scheiba, Nina ^a   Engstner, Monika ^a   Flux, Katharina ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

2 adrenoceptor; infantile hemangioma; propranolol; senile hemangioma

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; PROPRANOLOL; TUMOR PROTEIN;

BIOSYNTHESIS; CAPILLARY HEMANGIOMA; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; HEAD AND NECK TUMOR; HUMAN; INFANT; LETTER; MALE; METABOLISM; PATHOLOGY; SKIN TUMOR;

ADRENERGIC BETA-ANTAGONISTS; FEMALE; GENE EXPRESSION REGULATION; HEAD AND NECK NEOPLASMS; HEMANGIOMA, CAPILLARY; HUMANS; INFANT; MALE; NEOPLASM PROTEINS; PROPRANOLOL; RECEPTORS, ADRENERGIC, BETA-2; SKIN NEOPLASMS;

EID: 84865398346     PISSN: 03036987     EISSN: 16000560     Source Type: Journal    
DOI: 10.1111/j.1600-0560.2012.01937.x     Document Type: Letter

References (5)

1. Leaute-Labreze C, Dumas de la Roque E, Hubiche T, Boralevi F, Thambo JB, Taieb A,. Propranolol for severe hemangiomas of infancy. N Engl J Med 2008; 358: 2649.
2. Johnson M,. The beta-adrenoceptor. Am J Respir Crit Care Med 1998; 158: S146.
3. Jinnin M, Ishihara T, Boye E, Olsen BR,. Recent progress in studies of infantile hemangioma. J Dermatol 2010; 37: 283.
4. Emilien G, Maloteaux JM,. Current therapeutic uses and potential of beta-adrenoceptor agonists and antagonists. Eur J Clin Pharmacol 1998; 53: 389.
5. Jinnin M, Medici D, Park L, et al. Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. Nat Med 2008; 14: 1236.