Development of a rapid and inexpensive assay for detecting a surrogate genetic polymorphism of HLA-B*58:01: A partially predictive but useful biomarker for allopurinol-related stevens-johnson syndrome/toxic epidermal necrolysis in Japanese

Drug Metabolism and Pharmacokinetics

Volumn 27, Issue 4, 2012, Pages 447-450

  Maekawa, Keiko ^a   Nishikawa, Jun ^a   Kaniwa, Nahoko ^a   Sugiyama, Emiko ^a   Koizumi, Tomoko ^a   Kurose, Kouichi ^a   Tohkin, Masahiro ^b   Saito, Yoshiro ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Allopurinol; PCR RFLP; Screening test; Stevens Johnson syndrome; Toxic epidermal necrolysis

Indexed keywords

ALLOPURINOL; ENZYME FOKI; RESTRICTION ENDONUCLEASE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; CONTROLLED STUDY; DRUG INDUCED DISEASE; GENE; GENE FREQUENCY; GENE IDENTIFICATION; GENE LINKAGE DISEQUILIBRIUM; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENOTYPE; HETEROZYGOSITY; HLA B 58 01 GENE; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; NOTE; PHARMACOGENOMICS; PSORS1C1 GENE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; STEVENS JOHNSON SYNDROME; TOXIC EPIDERMAL NECROLYSIS;

EID: 84865397208     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-11-NT-120     Document Type: Article

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