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Volumn 904, Issue , 2012, Pages 29-34
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Determination of the thrombin inhibitor AZD0837 and its metabolites in human bile using mixed mode solid phase extraction and LC-MS/MS
a
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Author keywords
Fused core liquid chromatography; Human bile; Mixed mode solid phase extraction; Thrombin inhibitor
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Indexed keywords
ACETIC ACID CONCENTRATION;
AMMONIUM ACETATE;
ANALYTES;
CHROMATOGRAPHIC SEPARATIONS;
CYCLE TIME;
EXCHANGE COLUMNS;
EXTRACTION RECOVERY;
FUSED-CORE;
HIGH CONCENTRATION;
HIGH IONIC STRENGTH;
HIGH-FLOW RATE;
HUMAN BILE;
INTERNAL STANDARDS;
LC-MS/MS;
LINEARITY RANGE;
MIXED MODE;
MIXED-MODE SOLID-PHASE EXTRACTION;
POSITIVE ELECTROSPRAY IONIZATION;
REVERSED PHASE;
SOLID-PHASE EXTRACTION;
THROMBIN INHIBITORS;
AMMONIUM COMPOUNDS;
BIOMOLECULES;
ELECTROSPRAY IONIZATION;
ENZYMES;
IONIC STRENGTH;
ISOTOPES;
LIQUID CHROMATOGRAPHY;
MASS SPECTROMETRY;
METABOLITES;
METHANOL;
BODY FLUIDS;
AMMONIUM ACETATE;
AR H067637;
AR H069927;
ATECEGATRAN METOXIL;
DRUG METABOLITE;
METHANOL;
PRODRUG;
UNCLASSIFIED DRUG;
ACCURACY;
ANALYTIC METHOD;
ANION EXCHANGE;
ARTICLE;
BILE;
CONTROLLED STUDY;
DRUG DETERMINATION;
ELUTION;
FLOW RATE;
HUMAN;
HYDROPHOBICITY;
IONIC STRENGTH;
LIQUID CHROMATOGRAPHY;
MALE;
NORMAL HUMAN;
PRIORITY JOURNAL;
SEPARATION TECHNIQUE;
SOLID PHASE EXTRACTION;
TANDEM MASS SPECTROMETRY;
TECHNOLOGY;
VALIDATION PROCESS;
AMIDINES;
ANTITHROMBINS;
AZETIDINES;
BILE;
CHROMATOGRAPHY, LIQUID;
DRUG STABILITY;
HUMANS;
LINEAR MODELS;
MALE;
METHANOL;
REPRODUCIBILITY OF RESULTS;
SOLID PHASE EXTRACTION;
TANDEM MASS SPECTROMETRY;
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EID: 84865367307
PISSN: 15700232
EISSN: 1873376X
Source Type: Journal
DOI: 10.1016/j.jchromb.2012.06.026 Document Type: Article |
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Times cited : (2)
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References (7)
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