Effect of IVIg on human dendritic cell-mediated antigen uptake and presentation: Role of lipid accumulation

Journal of Autoimmunity

Volumn 39, Issue 3, 2012, Pages 168-172

  Othy, Shivashankar ^a,b   Bruneval, Patrick ^d   Topçu, Selma ^a,b   Dugail, Isabelle ^a,b,c   Delers, Francisco ^a,b,c   Lacroix Desmazes, Sebastien ^a,b,c,e   Bayry, Jagadeesh ^a,b,c,e   Kaveri, Srini V ^a,b,c,e  

^a INSERM   (France)

^b CENTRE DE RECHERCHE DES CORDELIERS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d PARIS CARDIOVASCULAR RESEARCH CENTER   (France)

^e NATIONAL INSTITUTE OF IMMUNOHAEMATOLOGY   (India)

Author keywords

Antigen presentation; Autoimmunity; Dendritic cells; Intravenous immunoglobulin; Lipids

Indexed keywords

ANTIGEN; IMMUNOGLOBULIN G;

ANTIGEN PRESENTATION; ARTICLE; AUTOINFLAMMATORY DISEASE; CELL DIFFERENTIATION; CONTROLLED STUDY; DENDRITIC CELL; ELECTRON MICROSCOPY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOREGULATION; LIPID STORAGE; NORMAL HUMAN; PRIORITY JOURNAL;

ANTIGEN PRESENTATION; ANTIGENS; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; ENDOCYTOSIS; FLOW CYTOMETRY; FLUORESCENT DYES; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; LIPID METABOLISM; LIPIDS; MICROSCOPY, ELECTRON, TRANSMISSION; MONOCYTES;

EID: 84865365716     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2012.05.013     Document Type: Article

References (76)

1. Banchereau J., Steinman R.M. Dendritic cells and the control of immunity. Nature 1998, 392:245-252.
2. Steinman R.M., Banchereau J. Taking dendritic cells into medicine. Nature 2007, 449:419-426.
3. Brooks W.H., Le Dantec C., Pers J.O., Youinou P., Renaudineau Y. Epigenetics and autoimmunity. J Autoimmun 2010, 34:J207-J219.
4. Youinou P., Haralampos M. Moutsopoulos: a lifetime in autoimmunity. J Autoimmun 2010, 35:171-175.
5. Youinou P., Pers J.O. The international symposium on Sjogren's syndrome in Brest: the "top of the tops" at the "tip of the tips". Autoimmun Rev 2010, 9:589-590.
6. Youinou P., Pers J.O., Gershwin M.E., Shoenfeld Y. Geo-epidemiology and autoimmunity. J Autoimmun 2010, 34:J163-J167.
7. Tobon G.J., Youinou P., Saraux A. The environment, geo-epidemiology, and autoimmune disease: Rheumatoid arthritis. Autoimmun Rev 2010, 9:A288-A292.
8. Piconese S., Costanza M., Tripodo C., Sangaletti S., Musio S., Pittoni P., et al. The matricellular protein SPARC supports follicular dendritic cell networking toward Th17 responses. J Autoimmun 2011, 37:300-310.
9. Mageed R.A., Garaud S., Taher T.E., Parikh K., Pers J.O., Jamin C., et al. CD5 expression promotes multiple intracellular signaling pathways in B lymphocyte. Autoimmun Rev 2012, 10.1016/j.autrev.2012.02.007.
10. Guerrier T., Le Pottier L., Devauchelle V., Pers J.O., Jamin C., Youinou P. Role of toll-like receptors in primary Sjogren's syndrome with a special emphasis on B-cell maturation within exocrine tissues. J Autoimmun 2012, 39:69-76.
11. Lemoine S., Morva A., Youinou P., Jamin C. Human T cells induce their own regulation through activation of B cells. J Autoimmun 2011, 36:228-238.
12. Tobon G.J., Youinou P., Saraux A. The environment, geo-epidemiology, and autoimmune disease: Rheumatoid arthritis. J Autoimmun 2010, 35:10-14.
13. Roguedas A.M., Pers J.O., Lemasson G., Devauchelle V., Tobon G.J., Saraux A., et al. Memory B-cell aggregates in skin biopsy are diagnostic for primary Sjogren's syndrome. J Autoimmun 2010, 35:241-247.
14. Lu Q., Renaudineau Y., Cha S., Ilei G., Brooks W.H., Selmi C., et al. Epigenetics in autoimmune disorders: highlights of the 10th Sjogren's syndrome symposium. Autoimmun Rev 2010, 9:627-630.
15. Galeotti C., Bayry J., Kone-Paut I., Kaveri S.V. Kawasaki disease: aetiopathogenesis and therapeutic utility of intravenous immunoglobulin. Autoimmun Rev 2010, 9:441-448.
16. Alonso R., Buors C., Le Dantec C., Hillion S., Pers J.O., Saraux A., et al. Aberrant expression of CD6 on B-cell subsets from patients with Sjogren's syndrome. J Autoimmun 2010, 35:336-341.
17. Agmon-Levin N., Shapira Y., Selmi C., Barzilai O., Ram M., Szyper-Kravitz M., et al. A comprehensive evaluation of serum autoantibodies in primary biliary cirrhosis. J Autoimmun 2010, 34:55-58.
18. Buhe V., Pers J.O., Marianowski R., Berthou C., Youinou P., Loisel S. Development of a Murine model to dissect the CpG-oligonucleotide-enhancement of the killing of human B Cells by rituximab. J Autoimmun 2010, 34:136-144.
19. Bayry J., Lacroix-Desmazes S., Kazatchkine M.D., Kaveri S.V. Monoclonal antibody and intravenous immunoglobulin therapy for rheumatic diseases: rationale and mechanisms of action. Nat Clin Pract Rheumatol 2007, 3:262-272.
20. Arnson Y., Shoenfeld Y., Amital H. Intravenous immunoglobulin therapy for autoimmune diseases. Autoimmunity 2009, 42:553-560.
21. Seite J.F., Shoenfeld Y., Youinou P., Hillion S. What is the contents of the magic draft IVIg?. Autoimmun Rev 2008, 7:435-439.
22. Kazatchkine M.D., Kaveri S.V. Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin. N Engl J Med 2001, 345:747-755.
23. Nussinovitch U., Shoenfeld Y. Intravenous immunoglobulin - indications and mechanisms in cardiovascular diseases. Autoimmun Rev 2008, 7:445-452.
24. Katz U., Achiron A., Sherer Y., Shoenfeld Y. Safety of intravenous immunoglobulin (IVIG) therapy. Autoimmun Rev 2007, 6:257-259.
25. Bayry J., Negi V.S., Kaveri S.V. Intravenous immunoglobulin therapy in rheumatic diseases. Nat Rev Rheumatol 2011, 7:349-359.
26. Kaveri S.V., Lacroix-Desmazes S., Bayry J. The antiinflammatory IgG. N Engl J Med 2008, 359:307-309.
27. Tha-In T., Bayry J., Metselaar H.J., Kaveri S.V., Kwekkeboom J. Modulation of the cellular immune system by intravenous immunoglobulin. Trends Immunol 2008, 29:608-615.
28. Seite J.F., Guerrier T., Cornec D., Jamin C., Youinou P., Hillion S. TLR9 responses of B cells are repressed by intravenous immunoglobulin through the recruitment of phosphatase. J Autoimmun 2011, 37:190-197.
29. Bayry J., Fournier E.M., Maddur M.S., Vani J., Wootla B., Siberil S., et al. Intravenous immunoglobulin induces proliferation and immunoglobulin synthesis from B cells of patients with common variable immunodeficiency: a mechanism underlying the beneficial effect of IVIg in primary immunodeficiencies. J Autoimmun 2011, 36:9-15.
30. Kaveri S.V. Intravenous immunoglobulin: Exploiting the potential of natural antibodies. Autoimmun Rev 2012, 10.1016/j.autrev.2012.02.006.
31. Bayry J., Lacroix-Desmazes S., Carbonneil C., Misra N., Donkova V., Pashov A., et al. Inhibition of maturation and function of dendritic cells by intravenous immunoglobulin. Blood 2003, 101:758-765.
32. Bayry J., Lacroix-Desmazes S., Delignat S., Mouthon L., Weill B., Kazatchkine M.D., et al. Intravenous immunoglobulin abrogates dendritic cell differentiation induced by interferon-alpha present in serum from patients with systemic lupus erythematosus. Arthritis Rheum 2003, 48:3497-3502.
33. Sherer Y., Shoenfeld Y. Intravenous immunoglobulin for immunomodulation of systemic lupus erythematosus. Autoimmun Rev 2006, 5:153-155.
34. Siragam V., Crow A.R., Brinc D., Song S., Freedman J., Lazarus A.H. Intravenous immunoglobulin ameliorates ITP via activating Fc gamma receptors on dendritic cells. Nat Med 2006, 12:688-692.
35. Aubin E., Lemieux R., Bazin R. Indirect inhibition of in vivo and in vitro T-cell responses by intravenous immunoglobulins due to impaired antigen presentation. Blood 2010, 115:1727-1734.
36. Piemonti L., Monti P., Allavena P., Sironi M., Soldini L., Leone B.E., et al. Glucocorticoids affect human dendritic cell differentiation and maturation. J Immunol 1999, 162:6473-6481.
37. Yamamoto M., Kobayashi K., Ishikawa Y., Nakata K., Funada Y., Kotani Y., et al. The inhibitory effects of intravenous administration of rabbit immunoglobulin G on airway inflammation are dependent upon Fcgamma receptor IIb on CD11c(+) dendritic cells in a murine model. Clin Exp Immunol 2010, 162:315-324.
38. Smed-Sorensen A., Moll M., Cheng T.Y., Lore K., Norlin A.C., Perbeck L., et al. IgG regulates the CD1 expression profile and lipid antigen-presenting function in human dendritic cells via FcgammaRIIa. Blood 2008, 111:5037-5046.
39. Melo R.C., D'Avila H., Bozza P.T., Weller P.F. Imaging lipid bodies within leukocytes with different light microscopy techniques. Methods Mol Biol 2011, 689:149-161.
40. Melo R.C., D'Avila H., Wan H.C., Bozza P.T., Dvorak A.M., Weller P.F. Lipid bodies in inflammatory cells: structure, function, and current imaging techniques. J Histochem Cytochem 2011, 59:540-556.
41. Schmitz G., Grandl M. Lipid homeostasis in macrophages - implications for atherosclerosis. Rev Physiol Biochem Pharmacol 2008, 160:93-125.
42. Bozza P.T., Payne J.L., Morham S.G., Langenbach R., Smithies O., Weller P.F. Leukocyte lipid body formation and eicosanoid generation: cyclooxygenase-independent inhibition by aspirin. Proc Natl Acad Sci U S A 1996, 93:11091-11096.
43. Triggiani M., Oriente A., Seeds M.C., Bass D.A., Marone G., Chilton F.H. Migration of human inflammatory cells into the lung results in the remodeling of arachidonic acid into a triglyceride pool. J Exp Med 1995, 182:1181-1190.
44. Vieira-de-Abreu A., Calheiros A.S., Mesquita-Santos F.P., Magalhaes E.S., Mourao-Sa D., Castro-Faria-Neto H.C., et al. Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene C(4)-synthesizing lipid bodies. Am J Respir Cell Mol Biol 2011, 44:509-516.
45. Schwenk R.W., Holloway G.P., Luiken J.J., Bonen A., Glatz J.F. Fatty acid transport across the cell membrane: regulation by fatty acid transporters. Prostaglandins Leukot Essent Fatty Acids 2010, 82:149-154.
46. Maddur M.S., Hegde P., Sharma M., Kaveri S.V., Bayry J. B cells are resistant to immunomodulation by 'IVIg-educated' dendritic cells. Autoimmun Rev 2011, 11:154-156.
47. Bayry J., Mouthon L., Kaveri S.V. Intravenous immunoglobulin expands regulatory T cells in autoimmune rheumatic disease. J Rheumatol 2012, 39:450-451.
48. Bayry J., Bansal K., Kazatchkine M.D., Kaveri S.V. DC-SIGN and alpha2,6-sialylated IgG Fc interaction is dispensable for the anti-inflammatory activity of IVIg on human dendritic cells. Proc Natl Acad Sci U S A 2009, 106:E24.
49. Shoenfeld Y., Rauova L., Gilburd B., Kvapil F., Goldberg I., Kopolovic J., et al. Efficacy of IVIG affinity-purified anti-double-stranded DNA anti-idiotypic antibodies in the treatment of an experimental murine model of systemic lupus erythematosus. Int Immunol 2002, 14:1303-1311.
50. Roopenian D.C., Akilesh S. FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol 2007, 7:715-725.
51. Basta M., Van Goor F., Luccioli S., Billings E.M., Vortmeyer A.O., Baranyi L., et al. F(ab)'2-mediated neutralization of C3a and C5a anaphylatoxins: a novel effector function of immunoglobulins. Nat Med 2003, 9:431-438.
52. Arumugam T.V., Tang S.C., Lathia J.D., Cheng A., Mughal M.R., Chigurupati S., et al. Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death. Proc Natl Acad Sci U S A 2007, 104:14104-14109.
53. Raju R., Dalakas M.C. Gene expression profile in the muscles of patients with inflammatory myopathies: effect of therapy with IVIg and biological validation of clinically relevant genes. Brain 2005, 128:1887-1896.
54. Anthony R.M., Kobayashi T., Wermeling F., Ravetch J.V. Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway. Nature 2011, 475:110-113.
55. Kaneko Y., Nimmerjahn F., Ravetch J.V. Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation. Science 2006, 313:670-673.
56. Tackenberg B., Jelcic I., Baerenwaldt A., Oertel W.H., Sommer N., Nimmerjahn F., et al. Impaired inhibitory Fcgamma receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy. Proc Natl Acad Sci U S A 2009, 106:4788-4792.
57. Crow A.R., Song S., Semple J.W., Freedman J., Lazarus A.H. A role for IL-1 receptor antagonist or other cytokines in the acute therapeutic effects of IVIg?. Blood 2007, 109:155-158.
58. Durandy A., Kaveri S.V., Kuijpers T.W., Basta M., Miescher S., Ravetch J.V., et al. Intravenous immunoglobulins-understanding properties and mechanisms. Clin Exp Immunol 2009, 158(1):2-13.
59. Pashov A., Dubey C., Kaveri S.V., Lectard B., Huang Y.M., Kazatchkine M.D., et al. Normal immunoglobulin G protects against experimental allergic encephalomyelitis by inducing transferable T cell unresponsiveness to myelin basic protein. Eur J Immunol 1998, 28:1823-1831.
60. Ephrem A., Chamat S., Miquel C., Fisson S., Mouthon L., Caligiuri G., et al. Expansion of CD4+CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis. Blood 2008, 111:715-722.
61. Maddur M.S., Vani J., Hegde P., Lacroix-Desmazes S., Kaveri S.V., Bayry J. Inhibition of differentiation, amplification, and function of human TH17 cells by intravenous immunoglobulin. J Allergy Clin Immunol 2011, 127:823-830. e1-7.
62. Maddur M.S., Kaveri S.V., Bayry J. Comparison of different IVIg preparations on IL-17 production by human Th17 cells. Autoimmun Rev 2011, 10:809-810.
63. Herber D.L., Cao W., Nefedova Y., Novitskiy S.V., Nagaraj S., Tyurin V.A., et al. Lipid accumulation and dendritic cell dysfunction in cancer. Nat Med 2010, 16:880-886.
64. Bozza P.T., Viola J.P. Lipid droplets in inflammation and cancer. Prostaglandins Leukot Essent Fatty Acids 2010, 82:243-250.
65. Bougneres L., Helft J., Tiwari S., Vargas P., Chang B.H., Chan L., et al. A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells. Immunity 2009, 31:232-244.
66. Loscher C.E., Draper E., Leavy O., Kelleher D., Mills K.H., Roche H.M. Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction. J Immunol 2005, 175:4990-4998.
67. Weatherill A.R., Lee J.Y., Zhao L., Lemay D.G., Youn H.S., Hwang D.H. Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4. J Immunol 2005, 174:5390-5397.
68. Seite J.F., Cornec D., Renaudineau Y., Youinou P., Mageed R.A., Hillion S. IVIg modulates BCR signaling through CD22 and promotes apoptosis in mature human B lymphocytes. Blood 2010, 116:1698-1704.
69. Behrens M., Smart M., Luckey D., Luthra H., Taneja V. To B or not to B: role of B cells in pathogenesis of arthritis in HLA transgenic mice. J Autoimmun 2011, 37:95-103.
70. Sharma R., Sung S.S., Ju C.Y., Deshmukh U.S., Fu S.M., Ju S.T. Regulatory T-Cell (Treg) hybridoma as a novel tool to study Foxp3 regulation and Treg fate. J Autoimmun 2011, 37:113-121.
71. Mackay I.R., Leskovsek N.V., Rose N.R. The odd couple: a fresh look at autoimmunity and immunodeficiency. J Autoimmun 2010, 35:199-205.
72. Routsias J.G., Tzioufas A.G. B-cell epitopes of the intracellular autoantigens Ro/SSA and La/SSB: tools to study the regulation of the autoimmune response. J Autoimmun 2010, 35:256-264.
73. Gershwin M.E., Shoenfeld Y. Chella David: a lifetime contribution in translational immunology. J Autoimmun 2011, 37:59-62.
74. Rose N.R. The genetics of autoimmune thyroiditis: the first decade. J Autoimmun 2011, 37:88-94.
75. Youinou P., Haralampos M. Moutsopoulos: a lifetime in autoimmunity. J Autoimmun 2010, 35:171-175.
76. Miyagawa F., Gutermuth J., Zhang H., Katz S.I. The use of mouse models to better understand mechanisms of autoimmunity and tolerance. J Autoimmun 2010, 35:192-198.