Regional distribution of technetium-99m-ECD in the canine brain: Optimal injection-acquisition interval in adult beagles

Journal of Veterinary Behavior: Clinical Applications and Research

Volumn 7, Issue 5, 2012, Pages 261-267

  Waelbers, Tim ^a   Peremans, Kathelijne ^a   Vermeire, Simon ^a   Piron, Koen ^a   Polis, Ingeborgh ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

99mTc ECD; Brain perfusion; Dogs; RCBF; SPECT

Indexed keywords

EID: 84865361605     PISSN: 15587878     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jveb.2012.05.001     Document Type: Article

References (24)

1. Catafau A.M. Brain SPECT in clinical practice. Part 1: Perfusion. J. Nucl. Med. 2001, 42:259-271.
2. Devous M.D., Payne J.K., Lowe J.L., Leroy R.F. Comparison of technetium-99M-ECD to Xe-133 SPECT in normal controls and in patients with mild-to-moderate regional cerebral blood-flow abnormalities. J. Nucl. Med. 1993, 34:754-761.
3. Goethals I., Audenaert K., Jacobs F., Van den Eynde F., Bernagie K., Kolindou A., Vervaet M., Dierckx R., Van Heeringen C. Brain perfusion SPECT in impulsivity-related personality disorders. Behav. Brain Res. 2005, 157:187-192.
4. Goethals I., Vervaet M., Audenaert K., Jacobs H., Ham H., Van Heeringen C. Does regional brain perfusion correlate with eating disorder symptoms in anorexia and bulimia nervosa patients?. J. Psych. Res. 2007, 41:1005-1011.
5. Grunwald F., Menzel C., Pavics L., Bauer J., Hufnagel A., Reichmann K., Sakowski R., Elger C.E., Biersack H.J. Ictal and interictal brain SPECT imaging in epilepsy using technetium-99m-ECD. J. Nucl. Med. 1994, 35:1896-1901.
6. Harvey R.C., Greene S.A., Thomas W.B. Neurological disease. Lumb and Jones' Veterinary Anesthesia an Analgesia 2007, 903-913. Blackwell Publishing Ltd, Oxford. 4th Ed. W.J. Tranquilli, J.C. Thurmon, K.A. Grimm (Eds.).
7. Ichise M., Golan H., Ballinger J.R., Vines D., Blackman A., Moldofsky H. Regional differences in technetium-99m-ECD clearance on brain SPECT in healthy subjects. J. Nucl. Med. 1997, 38:1253-1260.
8. Koyama M., Kawashima R., Ito H., Ono S., Sato K., Goto R., Kinomura S., Yoshioka S., Sato T., Fukuda H. SPECT imaging of normal subjects with technetium-99m-HMPAO and technetium-99m-ECD. J. Nucl. Med. 1997, 38:587-592.
9. Leveille J., Demonceau G., Deroo M., Rigo P., Taillefer R., Morgan R.A., Kupranick D., Walovitch R.C. Characterization of technetium-99m L, L-ECD for brain perfusion imaging: biodistribution and brain imaging in humans. J. Nucl. Med. 1989, 30:1902-1910.
10. Leveille J., Demonceau G., Walovitch R.C. Intrasubject comparison between technetium-99m-ECD and technetium-99m-HMPAO in healthy human subjects. J. Nucl. Med. 1992, 33:480-484.
11. Linden D.E. The challenges and promise of neuroimaging in psychiatry. Neuron 2012, 73:8-22.
12. Martlé V., Peremans K., Audenaert K., Vermeire S., Bhatti S., Gielen I., Polis I., Van Ham L. Regional brain perfusion in epileptic dogs evaluated by technetium-99m-Ethyl Cysteinate Dimer SPECT. Vet. Radiol. Ultrasound 2009, 50:655-659.
13. Peremans, K., 2002. Functional brain imaging in the dog. Single photon emission tomography as a research and clinical tool for the investigation of canine brain physiology and pathophysiology, PhD dissertation, Ghent University.
14. Peremans K., Audenaert K., Coopman F., Blanckaert P., Jacobs F., Otte A., Verschooten F., Van Bree H., van Heeringen K., Mertens J., Slegers G., Dierckx R. Estimates of regional cerebral blood flow and 5-HT2A receptor density in impulsive, aggressive dogs with Tc-99m-ECD and I-123-5-I-R91150. Eur. J. Nucl. Med. Mol. Imaging 2003, 30:1538-1546.
15. Peremans K., De Bondt P., Audenaert K., Van Laere K., Gielen I., Koole M., Versijpt J., van Bree H., Verschooten F., Dierckx R. Regional brain perfusion in 10 normal dogs measured using technetium-99m ethyl cysteinate dimer SPECT. Vet. Radiol. Ultrasound 2001, 42:562-568.
16. Schlunzen L., Cold G.E., Rasmussen M., Vafaee M.S. Effects of dose-dependent levels of isoflurane on cerebral blood flow in healthy subjects studied using positron emission tomography. Acta Anaesth. Scand. 2006, 50:306-312.
17. Vallabhajosula S., Zimmerman R.E., Picard M., Stritzke P., Mena I., Hellman R.S., Tikofsky R.S., Stabin M.G., Morgan R.A., Goldsmith S.J. Technetium-99m ECD-a new brain imaging agent-in vivo kinetics and biodistribution studies in normal human-subjects. J. Nucl. Med. 1989, 30:599-604.
18. Vermeire S., Audenaert K., De Meester R., Vandermeulen E., Waelbers T., De Spiegeleer B., Eersels J., Dobbeleir A., Peremans K. Serotonin 2A receptor, serotonin transporter and dopamine transporter alterations in dogs with compulsive behaviour as a promising model for human obsessive-compulsive disorder. Psychiat. Res. 2012, 201:78-87.
19. Vermeire S.T., Audenaert K.R., Dobbeleir A.A., De Meester R.H., De Vos F.J., Peremans K.Y. Evaluation of the brain 5-HT2A receptor binding index in dogs with anxiety disorders, measured with I-123-5I-R91150 and SPECT. J. Nucl. Med. 2009, 50:284-289.
20. Vermeire S., Audenaert K., Dobbeleir A., Vandermeulen E., Waelbers T., Peremans K. A Cavalier King Charles dog with shadow chasing: clinical recovery and normalization of the dopamine transporter binding after clomipramine treatment. J. Vet. Behav.: Clin. Appl. Res. 2010, 5:345-349.
21. Waelbers T., Peremans K., Gielen I., Vermeire S., Polis I. Brain perfusion part 2: anesthesia and brain perfusion in small animals. Vlaam. Diergeneeskd. Tijdschr. 2010, 79:179-188.
22. Waelbers T., Peremans K., Vermeire S., Duchateau L., Dobbeleir A., Audenaert K., Polis I. The effect of medetomidine on the regional cerebral blood flow in dogs measured using Technetium-99m-Ethyl Cysteinate Dimer SPECT. Res. Vet. Sci. 2011, 91:138-143.
23. Waelbers T., Peremans K., Vermeire S., Piron K., Doom M., Boer V.O., de Leeuw H., Vente M.A., Dobbeleir A., Gielen I., Audenaert K., Polis I. Effects of medetomidine and ketamine on the regional cerebral blood flow in cats: a SPECT study. Vet. J. 2012, 192:81-88.
24. Walovitch R.C., Cheesman E.H., Maheu L.J., Hall K.M. Studies of the retention mechanism of the brain perfusion imaging agent Tc-99m-bicisate (Tc-99m-ECD). J. Cereb. Blood Flow Metab 1994, 14:S4-S11.