Superparamagnetic iron oxide nanoparticles as radiosensitizer via enhanced reactive oxygen species formation

Biochemical and Biophysical Research Communications

Volumn 425, Issue 2, 2012, Pages 393-397

  Klein, Stefanie ^a   Sommer, Anja ^a   Distel, Luitpold V R ^a   Neuhuber, Winfried ^a   Kryschi, Carola ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Fenton reaction; Haber Weiss reaction; Radiosensitizer; Reactive oxygen species; Superparamagnetic iron oxide nanoparticles

Indexed keywords

IRON; REACTIVE OXYGEN METABOLITE; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE;

ARTICLE; CATALYSIS; CELL STRAIN MCF 7; CELL VIABILITY; CHEMICAL REACTION; CYTOTOXICITY; FENTON REACTION; HABER WEISS REACTION; HUMAN; HUMAN CELL; IN VITRO STUDY; OXIDATIVE STRESS; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; X IRRADIATION;

CELL LINE, TUMOR; FERRIC COMPOUNDS; HUMANS; MAGNETITE NANOPARTICLES; NEOPLASMS; RADIATION-SENSITIZING AGENTS; REACTIVE OXYGEN SPECIES; X-RAYS;

EID: 84865360012     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.07.108     Document Type: Article

References (22)

1. Sun C., Lee J.S.E., Zhang M. Magnetic nanoparticles in MR imaging and drug delivery. Adv. Drug Delivery Reviews 2008, 60:1252-1265.
2. Arbab A.S., Bashab L.A., Miller B.R., Jordan E.K., Lewis B.K., Kalish H., Frank J.A. Characterization of biophysical and metabolic properties of cells labeled with superparamagnetic iron oxide nanoparticles and transfection agent for cellular MR imaging. Radiology 2003, 229:838-846.
3. Mornet S., Vasseur S., Grasset F., Duguet E. Magnetic nanoparticle design of medical diagnosis and therapy. J. Mater. Chem. 2004, 14:2161-2175.
4. Tran N., Webster T.J. Magnetic nanoparticles: biomedical applications and challenges. J. Mater. Chem. 2010, 20:8760-8767.
5. Pankhurst Q.A., Connolly J., Jones S.K., Dobson J. Applications of magnetic nanoparticles in biomedicine. J. Phys. D, Appl. Phys. 2003, 36:R167-R181.
6. Frullano L., Meade T.J. Multimodal MRI contrast agents. J. Biol. Inorg. Chem. 2007, 12:939-949.
7. Lubbe A.S., Alexiou C., Bergemann C. Clinical applications of magnetic drug targeting. J. Surgical Res. 2001, 95:200-206.
8. Yu M.K., Jeong Y.Y., Park J., Park S., Kim J.W., Min J.J., Kim K., Jon S. Drug-loaded superparamagnetic iron oxide nanoparticles for combined cancer imaging and therapy in vivo. Angew. Chem. Int. Ed. 2008, 47:5362-5365.
9. Petri-Fink A., Chastellain M., Juillerat-Jeanneret L., Ferrari A., Hofmann H. Development of functionalized superparamagnetic iron oxide nanoparticles for interaction with human cancer cells. Biomaterials 2005, 26:2685-2694.
10. Schlachter E.K., Widmer H.R., Bregy A., Lönnfors-Weitzel T., Vajtai I., Corazza N., Bernau V.J.P., Weitzel T., Mordasini P., Slotboom J., Herrmann G., Bogni S., Hofmann H., Frenz M., Reiner M. Metabolic pathway and distribution of superparamagnetic iron oxide nanoparticles: in vivo study. Int. J. Nanomedicine 2011, 6:1793-1800.
11. Kim J.S., Yoon T.-J., Yu K.N., Kim B.G., Park S.J., Lee K.H., Park S.B., Lee J.-K., Cho M.H. Toxicity and tissue distribution of magnetic nanoparticles in mice. Toxicol. Sci. 2006, 89:338-347.
12. Weissleder R., Stark D.D., Engelstad B.L., Bacon B.R., Compton C.C., White D.L., Jacobs P., Lewis J. Superparamagnetic iron oxide: pharmacokinetics and toxicity. Am. J. Roentgenol. 1989, 152:167-173.
13. Voinov M.A., Pagan J.O.S., Morrison E., Smirnova T.I., Smirnov A. Surface-mediated production of hydroxyl radicals as a mechanism of iron oxide nanoparticle biotoxicity. J. Am. Chem. Soc. 2011, 133:35-41.
14. Lewinski N., Colvin V., Drezek R. Cytotoxicity of nanoparticles. Small 2008, 4:26-49.
15. M. Auffan, W. Achouak, J. Rose, M.-A. Roncato, C. Chaneac, D. T. Waite, A. Masion, J. C. Woicik, M. R. Wiesner J.-Y. Bottero, Relation between the redox state of iron-based nanoparticles and their cytotoxicity toward Escherichia coli, Environ. Sci. Technol. 42 (2008) 6730-6735.
16. Nel A., Xia T., Mädler L., Li N. Toxic potential of materials at the nanolevel. Science 2006, 311:622-627.
17. Emerit J., Beaumont C., Trivin F. Iron metabolism, free radicals, and oxidative injury. Biomed. Pharmacother. 2001, 55:333-339.
18. Mahmoudi M., Simchi A., Imani M., Shokrgozar M.A., Milani A.S., Häfeli U.O., Stroeve P. A new approach for the in vitro identification of the cytotoxicity of superparamagnetic iron oxide nanoparticles. Colloids Surf., B 2010, 75:300-309.
19. Juzenas P., Chen W., Sun Y.-P., Coelho M.A.N., Generalov R., Generalova N., Christensen I.L. Quantum dots and nanoparticles for photodynamic and radiation therapies of cancer. Adv. Drug Delivery Rev. 2008, 60:1600-1614.
20. Halliwell B., Aruoma O.L. DNA damage by oxygen-derived species. FEBS Lett. 1991, 281:9-19.
21. Massard R. Preparation of aqueous magnetic liquids in alkaline and acidic media. IEEE Trans. Magn. 1981, 17:1247-1248.
22. Qu H., Caruntu D., Liu H., O'Connor C.J. Water-dispersible iron oxide magnetic nanoparticles with versatile surface functionalities. Langmuir 2011, 27:2271-2278.