GNAS1 T393C polymorphism is associated with clinical course in patients with intrahepatic cholangiocarcinoma

Neoplasia

Volumn 9, Issue 2, 2007, Pages 159-165

  Schmitz, Klaus J ^a   Langy, Hauke ^a,b   Frey, Ulrich H ^b   Sotiropoulos, Georgios C ^a   Wohlschlaeger, Jeremias ^a   Reis, Henning ^a   Takeda, Atsushi ^c   Siffert, Winfried ^b,c   Schmid, Kurt Werner ^a,b   Baba, Hideo A ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c School of Physical Therapy   (Japan)

Author keywords

Cholangiocarcinoma; Disease free survival; GNAS1; Prognosis; Single nucleotide polymorphism

Indexed keywords

ADULT; ALLELE; APOPTOSIS; ARTICLE; BILE DUCT CARCINOMA; CANCER MORTALITY; CANCER SURVIVAL; CELL PROLIFERATION; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE COURSE; DISEASE FREE SURVIVAL; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HAZARD RATIO; HETEROZYGOTE; HIGH RISK PATIENT; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; NICK END LABELING; OUTCOME ASSESSMENT; PREDICTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 33847297531     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1593/neo.06796     Document Type: Article

References (28)

1. Khan SA, Taylor-Robinson SD, Toledano MB, Beck A, Elliott P, and Thomas HC (2002). Changing international trends in mortality rates for liver, biliary and pancreatic tumours. J Hepatol 37, 806-813.
2. Patel T (2001). Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States. Hepatology 33, 1353-1357.
3. Lang H, Sotiropoulos GC, Fruhauf NR, Domland M, Paul A, Kind EM, Malago M, and Broelsch CE (2005). Extended hepatectomy for intrahepatic cholangiocellular carcinoma (ICC): when is it worthwhile? Single center experience with 27 resections in 50 patients over a 5-year period. Ann Surg 241, 134-143.
4. Petmitr S (1997). Cancer genes and cholangiocarcinoma. Southeast Asian J Trop Med Public Health 28 (1), 80-84.
5. Levi S, Urbano-Ispizua A, Gill R, Thomas DM, Gilbertson J, Foster C, and Marshall CJ (1991). Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique. Cancer Res 51, 3497-3502.
6. Cheung ST, Ho JC, Leung KL, Chen X, Fong DY, So S, and Fan ST (2005). Transcript AA454543 is a novel prognostic marker for hepatocellular carcinoma after curative partial hepatectomy. Neoplasia 7, 91-98.
7. Cheung ST, Liu CL, Chow JP, Lee YT, Ip YC, Ho JC, and Fan ST (2006). Preoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy. Neoplasia 8, 696-701.
8. Frey UH, Eisenhardt A, Lummen G, Rubben H, Jockel KH, Schmid KW, and Siffert W (2005). The T393C polymorphism of the G alpha s gene (GNAS1) is a novel prognostic marker in bladder cancer. Cancer Epidemiol Biomark Prev 14, 871-877.
9. Frey UH, Alakus H, Wohlschlaeger J, Schmitz KJ, Winde G, van Calker HG, Jockel KH, Siffert W, and Schmid KW (2005). GNAS1 T393C polymorphism and survival in patients with sporadic colorectal cancer. Clin Cancer Res 11, 5071-5077.
10. Frey UH, Nuckel H, Sellmann L, Siemer D, Kuppers R, Durig J, Duhrsen U, and Siffert W (2006). The GNAS1 T393C polymorphism is associated with disease progression and survival in chronic lymphocytic leukemia. Clin Cancer Res 12, 5686-5692.
11. Frey UH, Lummen G, Jager T, Jockel KH, Schmid KW, Rubben H, Muller N, Siffert W, and Eisenhardt A (2006). The GNAS1 T393C polymorphism predicts survival in patients with clear cell renal cell carcinoma. Clin Cancer Res 12, 759-763.
12. Zuker M (2003). MFOLD web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 31, 3406-3415.
13. Myklebust JH, Josefsen D, Blomhoff HK, Levy FO, Naderi S, Reed JC, and Smeland EB (1999). Activation of the cAMP signaling pathway increases apoptosis in human B-precursor cells and is associated with downregulation of Mcl-1 expression. J Cell Physiol 180, 71-80.
14. Srivastava RK, Srivastava AR, Cho-Chung YS, and Longo DL (1999). Synergistic effects of retinoic acid and 8-Cl-cAMP on apoptosis require caspase-3 activation in human ovarian cancer cells. Oncogene 18, 1755-1763.
15. Wu EH, Tam BH, and Wong YH (2006). Constitutively active alpha subunits of G and G families inhibit activation of the pro-survival Akt signaling cascade. FEBS J 273, 2388-2398.
16. Yan L, Herrmann V, Hofer JK, and Insel PA (2000). Beta-adrenergic receptor/cAMP-mediated signaling and apoptosis of S49 lymphoma cells. Am J Physiol Cell Physiol 279, C1665-C1674.
17. Zhou B, Li F, Chen H, and Song J (2005). The modulation of apoptosis by cyclic AMP involves Akt and epidermal growth factor receptor. Int J Biochem Cell Biol 37, 1483-1495.
18. Sobin LH and Wittekind C (2002). International Union Against Cancer. TNM Classification of Malignant Tumours, 6th ed. New York, Wiley-Liss.
19. 3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J Am Soc Nephrol 10, 1921-1930.
20. Lang H, Sotiropoulos GC, Brokalaki E, Fruhauf NR, Radu J, Paul A, Wohlschlaeger J, Baba HA, Malago M, and Broelsch CE (2006). Surgical therapy of intrahepatic cholangiocellular carcinoma. Chirurg 77, 53-60.
21. 2-adrenergic receptor to different G proteins by protein kinase A. Nature 390, 88-91.
22. 2-adrenergic receptor, Gs, and adenylyl cyclase interactions. Biochem Pharmacol 54, 61-72.
23. Yang X, Lee FY Sr, and Wand GS (1997). Increased expression of Gs(alpha) enhances activation of the adenylyl cyclase signal transduction cascade. Mol Endocrinol 11, 1053-1061.
24. Otterbach F, Callies R, Frey UH, Schmitz KJ, Wreczycki C, Kimmig R, Siffert W, and Schmid KW (2006). The T393C polymorphism in the gene GNAS1 of G protein is associated with survival of patients with invasive breast carcinoma. Breast Cancer Res Treat (Epub ahead of print).
25. Harry A, Chen Y, Magnusson R, Iyengar R, and Weng G (1997). Differential regulation of adenylyl cyclases by Galphas. J Biol Chem 272, 19017-19021.
26. 2+-controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors. J Biol Chem 279, 46497-46508.
27. Kiermayer S, Biondi RM, Imig J, Plotz G, Haupenthal J, Zeuzem S, and Piiper A (2005). Epac activation converts cAMP from a proliferative into a differentiation signal in PC12 cells. Mol Biol Cell 16, 5639-5648.
28. Peyssonnaux C and Eychene A (2001). The Raf/MEK/ERK pathway: new concepts of activation. Biol Cell 93, 53-62.