-
1
-
-
0018943330
-
High-af fi nity binding to the estrogen receptor of [3 H]4-hydroxytamoxifen, an active antiestrogen metabolite
-
Borgna JL, Rochefort H (1980) High-af fi nity binding to the estrogen receptor of [3 H]4-hydroxytamoxifen, an active antiestrogen metabolite. Mol Cell Endocrinol 20:71-85
-
(1980)
Mol Cell Endocrinol
, vol.20
, pp. 71-85
-
-
Borgna, J.L.1
Rochefort, H.2
-
2
-
-
0036325773
-
Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: Formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen
-
Crewe HK, Notley LM, Wunsch RM, Lennard MS, Gillam EM (2002) Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos 30:869-874
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 869-874
-
-
Crewe, H.K.1
Notley, L.M.2
Wunsch, R.M.3
Lennard, M.S.4
Gillam, E.M.5
-
3
-
-
3342932419
-
Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen
-
Johnson MD, Zuo H, Lee KH, Trebley JP, Rae JM, Weatherman RV, Desta Z, Flockhart DA, Skaar TC (2004) Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen. Breast Cancer Res Treat 85:151-159
-
(2004)
Breast Cancer Res Treat
, vol.85
, pp. 151-159
-
-
Johnson, M.D.1
Zuo, H.2
Lee, K.H.3
Trebley, J.P.4
Rae, J.M.5
Weatherman, R.V.6
Desta, Z.7
Flockhart, D.A.8
Skaar, T.C.9
-
4
-
-
17644387537
-
Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen
-
Lim YC, Desta Z, Flockhart DA, Skaar TC (2005) Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen. Cancer Chemother Pharmacol 55:471-478
-
(2005)
Cancer Chemother Pharmacol
, vol.55
, pp. 471-478
-
-
Lim, Y.C.1
Desta, Z.2
Flockhart, D.A.3
Skaar, T.C.4
-
5
-
-
4243063941
-
Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6
-
Desta Z, Ward BA, Soukhova NV, Flockhart DA (2004) Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther 310: 1062-1075
-
(2004)
J Pharmacol Exp Ther
, vol.310
, pp. 1062-1075
-
-
Desta, Z.1
Ward, B.A.2
Soukhova, N.V.3
Flockhart, D.A.4
-
6
-
-
0020825481
-
Differential antiestrogen action in the immature rat uterus: A comparison of hydroxylated antiestrogens with high af fi nity for the estrogen receptor
-
Jordan VC, Gosden B (1983) Differential antiestrogen action in the immature rat uterus: a comparison of hydroxylated antiestrogens with high af fi nity for the estrogen receptor. J Steroid Biochem 19:1249-1258
-
(1983)
J Steroid Biochem
, vol.19
, pp. 1249-1258
-
-
Jordan, V.C.1
Gosden, B.2
-
7
-
-
0017665570
-
A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity
-
Jordan VC, Collins MM, Rowsby L, Prestwich G (1977) A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J Endocrinol 75:305-316
-
(1977)
J Endocrinol
, vol.75
, pp. 305-316
-
-
Jordan, V.C.1
Collins, M.M.2
Rowsby, L.3
Prestwich, G.4
-
8
-
-
0346602691
-
Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine
-
Stearns V, Johnson MD, Rae JM, Morocho A, Novielli A, Bhargava P, Hayes DF, Desta Z, Flockhart DA (2003) Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine. J Natl Cancer Inst 95:1758-1764
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 1758-1764
-
-
Stearns, V.1
Johnson, M.D.2
Rae, J.M.3
Morocho, A.4
Novielli, A.5
Bhargava, P.6
Hayes, D.F.7
Desta, Z.8
Flockhart, D.A.9
-
9
-
-
84878631451
-
-
http://www.cypalleles.ki.se/cyp2d6.htm
-
-
-
-
10
-
-
33644639136
-
Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of ef fi cacy and hot flashes
-
Goetz MP, Rae JM, Suman VJ, Safgren SL, Ames MM, Visscher DW, Reynolds C, Couch FJ, Lingle WL, Flockhart DA, Desta Z, Perez EA, Ingle JN (2005) Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of ef fi cacy and hot flashes. J Clin Oncol 23:9312-9318
-
(2005)
J Clin Oncol
, vol.23
, pp. 9312-9318
-
-
Goetz, M.P.1
Rae, J.M.2
Suman, V.J.3
Safgren, S.L.4
Ames, M.M.5
Visscher, D.W.6
Reynolds, C.7
Couch, F.J.8
Lingle, W.L.9
Flockhart, D.A.10
Desta, Z.11
Perez, E.A.12
Ingle, J.N.13
-
11
-
-
72449150287
-
Impact of CYP2D6 polymorphisms in tamoxifen adjuvant breast cancer treatment
-
Ramon YCT, Altes A, Pare L, Del Rio E, Alonso C, Barnadas A, Baiget M (2009) Impact of CYP2D6 polymorphisms in tamoxifen adjuvant breast cancer treatment. Breast Cancer Res Treat 119:33-38
-
(2009)
Breast Cancer Res Treat
, vol.119
, pp. 33-38
-
-
Ramon, Y.C.T.1
Altes, A.2
Pare, L.3
Del Rio, E.4
Alonso, C.5
Barnadas, A.6
Baiget, M.7
-
12
-
-
36349024762
-
Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes
-
Schroth W, Antoniadou L, Fritz P, Schwab M, Muerdter T, Zanger UM, Simon W, Eichelbaum M, Brauch H (2007) Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes. J Clin Oncol 25:5187-5193
-
(2007)
J Clin Oncol
, vol.25
, pp. 5187-5193
-
-
Schroth, W.1
Antoniadou, L.2
Fritz, P.3
Schwab, M.4
Muerdter, T.5
Zanger, U.M.6
Simon, W.7
Eichelbaum, M.8
Brauch, H.9
-
13
-
-
70349929431
-
Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen
-
Schroth W, Goetz MP, Hamann U, Fasching PA, Schmidt M, Winter S, Fritz P, Simon W, Suman VJ, Ames MM, Safgren SL, Kuffel MJ, Ulmer HU, Bolander J, Strick R, Beckmann MW, Koelbl H, Weinshilboum RM, Ingle JN, Eichelbaum M, Schwab M, Brauch H (2009) Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen. JAMA 302:1429-1436
-
(2009)
JAMA
, vol.302
, pp. 1429-1436
-
-
Schroth, W.1
Goetz, M.P.2
Hamann, U.3
Fasching, P.A.4
Schmidt, M.5
Winter, S.6
Fritz, P.7
Simon, W.8
Suman, V.J.9
Ames, M.M.10
Safgren, S.L.11
Kuffel, M.J.12
Ulmer, H.U.13
Bolander, J.14
Strick, R.15
Beckmann, M.W.16
Koelbl, H.17
Weinshilboum, R.M.18
Ingle, J.N.19
Eichelbaum, M.20
Schwab, M.21
Brauch, H.22
more..
-
14
-
-
47749105202
-
Association between CYP2D6 *10 genotype and survival of breast cancer patients receiving tamoxifen treatment
-
Xu Y, Sun Y, Yao L, Shi L, Wu Y, Ouyang T, Li J, Wang T, Fan Z, Fan T, Lin B, He L, Li P, Xie Y (2008) Association between CYP2D6 *10 genotype and survival of breast cancer patients receiving tamoxifen treatment. Ann Oncol 19: 1423-1429
-
(2008)
Ann Oncol
, vol.19
, pp. 1423-1429
-
-
Xu, Y.1
Sun, Y.2
Yao, L.3
Shi, L.4
Wu, Y.5
Ouyang, T.6
Li, J.7
Wang, T.8
Fan, Z.9
Fan, T.10
Lin, B.11
He, L.12
Li, P.13
Xie, Y.14
-
15
-
-
0037032497
-
Association between sulfotransferase 1A1 genotype and survival of breast cancer patients receiving tamoxifen therapy
-
Nowell S, Sweeney C, Winters M, Stone A, Lang NP, Hutchins LF, Kadlubar FF, Ambrosone CB (2002) Association between sulfotransferase 1A1 genotype and survival of breast cancer patients receiving tamoxifen therapy. J Natl Cancer Inst 94:1635-1640
-
(2002)
J Natl Cancer Inst
, vol.94
, pp. 1635-1640
-
-
Nowell, S.1
Sweeney, C.2
Winters, M.3
Stone, A.4
Lang, N.P.5
Hutchins, L.F.6
Kadlubar, F.F.7
Ambrosone, C.B.8
-
16
-
-
21344467511
-
Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients
-
Nowell SA, Ahn J, Rae JM, Scheys JO, Trovato A, Sweeney C, MacLeod SL, Kadlubar FF, Ambrosone CB (2005) Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients. Breast Cancer Res Treat 91:249-258
-
(2005)
Breast Cancer Res Treat
, vol.91
, pp. 249-258
-
-
Nowell, S.A.1
Ahn, J.2
Rae, J.M.3
Scheys, J.O.4
Trovato, A.5
Sweeney, C.6
MacLeod, S.L.7
Kadlubar, F.F.8
Ambrosone, C.B.9
-
17
-
-
70349899258
-
No association between CYP2D6*10 genotype and survival of nodenegative Japanese breast cancer patients receiving adjuvant tamoxifen treatment
-
Toyama T, Yamashita H, Sugiura H, Kondo N, Iwase H, Fujii Y (2009) No association between CYP2D6*10 genotype and survival of nodenegative Japanese breast cancer patients receiving adjuvant tamoxifen treatment. Jpn J Clin Oncol 39:651-656
-
(2009)
Jpn J Clin Oncol
, vol.39
, pp. 651-656
-
-
Toyama, T.1
Yamashita, H.2
Sugiura, H.3
Kondo, N.4
Iwase, H.5
Fujii, Y.6
-
18
-
-
34248208754
-
Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer
-
Wegman P, Elingarami S, Carstensen J, Stal O, Nordenskjold B, Wingren S (2007) Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer. Breast Cancer Res 9:R7
-
(2007)
Breast Cancer Res
, vol.9
-
-
Wegman, P.1
Elingarami, S.2
Carstensen, J.3
Stal, O.4
Nordenskjold, B.5
Wingren, S.6
-
19
-
-
77956255908
-
Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients
-
Borges S, Desta Z, Jin Y, Faouzi A, Robarge JD, Philip S, Nguyen A, Stearns V, Hayes D, Rae JM, Skaar TC, Flockhart DA, Li L (2010) Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients. J Clin Pharmacol 50: 450-458
-
(2010)
J Clin Pharmacol
, vol.50
, pp. 450-458
-
-
Borges, S.1
Desta, Z.2
Jin, Y.3
Faouzi, A.4
Robarge, J.D.5
Philip, S.6
Nguyen, A.7
Stearns, V.8
Hayes, D.9
Rae, J.M.10
Skaar, T.C.11
Flockhart, D.A.12
Li, L.13
-
20
-
-
77949392893
-
Nationwide drug-dispensing data reveal important differences in adherence to drug label recommendations on CYP2D6-dependent drug interactions
-
Mannheimer B, Wettermark B, Lundberg M, Pettersson H, von Bahr C, Eliasson E (2010) Nationwide drug-dispensing data reveal important differences in adherence to drug label recommendations on CYP2D6-dependent drug interactions. Br J Clin Pharmacol 69: 411-417
-
(2010)
Br J Clin Pharmacol
, vol.69
, pp. 411-417
-
-
Mannheimer, B.1
Wettermark, B.2
Lundberg, M.3
Pettersson, H.4
Von Bahr, C.5
Eliasson, E.6
-
21
-
-
56749152357
-
Cohort study examining tamoxifen adherence and its relationship to mortality in women with breast cancer
-
McCowan C, Shearer J, Donnan PT, Dewar JA, Crilly M, Thompson AM, Fahey TP (2008) Cohort study examining tamoxifen adherence and its relationship to mortality in women with breast cancer. Br J Cancer 99:1763-1768
-
(2008)
Br J Cancer
, vol.99
, pp. 1763-1768
-
-
McCowan, C.1
Shearer, J.2
Donnan, P.T.3
Dewar, J.A.4
Crilly, M.5
Thompson, A.M.6
Fahey, T.P.7
-
22
-
-
43249126529
-
Insight into barriers against optimal adherence to oral hormonal therapy in women with breast cancer
-
Kirk MC, Hudis CA (2008) Insight into barriers against optimal adherence to oral hormonal therapy in women with breast cancer. Clin Breast Cancer 8:155-161
-
(2008)
Clin Breast Cancer
, vol.8
, pp. 155-161
-
-
Kirk, M.C.1
Hudis, C.A.2
-
23
-
-
0037441639
-
Nonadherence to adjuvant tamoxifen therapy in women with primary breast cancer
-
Partridge AH, Wang PS, Winer EP, Avorn J (2003) Nonadherence to adjuvant tamoxifen therapy in women with primary breast cancer. J Clin Oncol 21:602-606
-
(2003)
J Clin Oncol
, vol.21
, pp. 602-606
-
-
Partridge, A.H.1
Wang, P.S.2
Winer, E.P.3
Avorn, J.4
-
24
-
-
0023922814
-
Identi fi cation of 4-hydroxy-N-desmethyltamoxifen as a metabolite of tamoxifen in human bile
-
Lien EA, Solheim E, Kvinnsland S, Ueland PM (1988) Identi fi cation of 4-hydroxy-N-desmethyltamoxifen as a metabolite of tamoxifen in human bile. Cancer Res 48:2304-2308
-
(1988)
Cancer Res
, vol.48
, pp. 2304-2308
-
-
Lien, E.A.1
Solheim, E.2
Kvinnsland, S.3
Ueland, P.M.4
-
25
-
-
33645224920
-
Liquid chromatography-mass spectrometry/mass spectrometry method development for drug metabolism studies: Examining lipid matrix ionization effects in plasma
-
Little JL, Wempe MF, Buchanan CM (2006) Liquid chromatography-mass spectrometry/mass spectrometry method development for drug metabolism studies: examining lipid matrix ionization effects in plasma. J Chromatogr B Analyt Technol Biomed Life Sci 833:219-230
-
(2006)
J Chromatogr B Analyt Technol Biomed Life Sci
, vol.833
, pp. 219-230
-
-
Little, J.L.1
Wempe, M.F.2
Buchanan, C.M.3
-
26
-
-
0021273172
-
Some chemical and biochemical aspects of liver microsomal metabolism of tamoxifen
-
Ruenitz PC, Bagley JR, Pape CW (1984) Some chemical and biochemical aspects of liver microsomal metabolism of tamoxifen. Drug Metab Dispos 12:478-483
-
(1984)
Drug Metab Dispos
, vol.12
, pp. 478-483
-
-
Ruenitz, P.C.1
Bagley, J.R.2
Pape, C.W.3
|