메뉴 건너뛰기




Volumn 902, Issue , 2012, Pages 211-222

Therapeutic drug monitoring of tamoxifen using LC-MS/MS

Author keywords

4 Hydroxy N desmethyltamoxifen; Endoxifen; LC MS MS; N Desmethyltamoxifen; Pharmacogenetics; Quantitation; Tamoxifen

Indexed keywords

TAMOXIFEN;

EID: 84865332781     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-934-1_19     Document Type: Article
Times cited : (9)

References (26)
  • 1
    • 0018943330 scopus 로고
    • High-af fi nity binding to the estrogen receptor of [3 H]4-hydroxytamoxifen, an active antiestrogen metabolite
    • Borgna JL, Rochefort H (1980) High-af fi nity binding to the estrogen receptor of [3 H]4-hydroxytamoxifen, an active antiestrogen metabolite. Mol Cell Endocrinol 20:71-85
    • (1980) Mol Cell Endocrinol , vol.20 , pp. 71-85
    • Borgna, J.L.1    Rochefort, H.2
  • 2
    • 0036325773 scopus 로고    scopus 로고
    • Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: Formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen
    • Crewe HK, Notley LM, Wunsch RM, Lennard MS, Gillam EM (2002) Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos 30:869-874
    • (2002) Drug Metab Dispos , vol.30 , pp. 869-874
    • Crewe, H.K.1    Notley, L.M.2    Wunsch, R.M.3    Lennard, M.S.4    Gillam, E.M.5
  • 4
    • 17644387537 scopus 로고    scopus 로고
    • Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen
    • Lim YC, Desta Z, Flockhart DA, Skaar TC (2005) Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen. Cancer Chemother Pharmacol 55:471-478
    • (2005) Cancer Chemother Pharmacol , vol.55 , pp. 471-478
    • Lim, Y.C.1    Desta, Z.2    Flockhart, D.A.3    Skaar, T.C.4
  • 5
    • 4243063941 scopus 로고    scopus 로고
    • Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6
    • Desta Z, Ward BA, Soukhova NV, Flockhart DA (2004) Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther 310: 1062-1075
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 1062-1075
    • Desta, Z.1    Ward, B.A.2    Soukhova, N.V.3    Flockhart, D.A.4
  • 6
    • 0020825481 scopus 로고
    • Differential antiestrogen action in the immature rat uterus: A comparison of hydroxylated antiestrogens with high af fi nity for the estrogen receptor
    • Jordan VC, Gosden B (1983) Differential antiestrogen action in the immature rat uterus: a comparison of hydroxylated antiestrogens with high af fi nity for the estrogen receptor. J Steroid Biochem 19:1249-1258
    • (1983) J Steroid Biochem , vol.19 , pp. 1249-1258
    • Jordan, V.C.1    Gosden, B.2
  • 7
    • 0017665570 scopus 로고
    • A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity
    • Jordan VC, Collins MM, Rowsby L, Prestwich G (1977) A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J Endocrinol 75:305-316
    • (1977) J Endocrinol , vol.75 , pp. 305-316
    • Jordan, V.C.1    Collins, M.M.2    Rowsby, L.3    Prestwich, G.4
  • 9
    • 84878631451 scopus 로고    scopus 로고
    • http://www.cypalleles.ki.se/cyp2d6.htm
  • 17
    • 70349899258 scopus 로고    scopus 로고
    • No association between CYP2D6*10 genotype and survival of nodenegative Japanese breast cancer patients receiving adjuvant tamoxifen treatment
    • Toyama T, Yamashita H, Sugiura H, Kondo N, Iwase H, Fujii Y (2009) No association between CYP2D6*10 genotype and survival of nodenegative Japanese breast cancer patients receiving adjuvant tamoxifen treatment. Jpn J Clin Oncol 39:651-656
    • (2009) Jpn J Clin Oncol , vol.39 , pp. 651-656
    • Toyama, T.1    Yamashita, H.2    Sugiura, H.3    Kondo, N.4    Iwase, H.5    Fujii, Y.6
  • 18
    • 34248208754 scopus 로고    scopus 로고
    • Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer
    • Wegman P, Elingarami S, Carstensen J, Stal O, Nordenskjold B, Wingren S (2007) Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer. Breast Cancer Res 9:R7
    • (2007) Breast Cancer Res , vol.9
    • Wegman, P.1    Elingarami, S.2    Carstensen, J.3    Stal, O.4    Nordenskjold, B.5    Wingren, S.6
  • 20
    • 77949392893 scopus 로고    scopus 로고
    • Nationwide drug-dispensing data reveal important differences in adherence to drug label recommendations on CYP2D6-dependent drug interactions
    • Mannheimer B, Wettermark B, Lundberg M, Pettersson H, von Bahr C, Eliasson E (2010) Nationwide drug-dispensing data reveal important differences in adherence to drug label recommendations on CYP2D6-dependent drug interactions. Br J Clin Pharmacol 69: 411-417
    • (2010) Br J Clin Pharmacol , vol.69 , pp. 411-417
    • Mannheimer, B.1    Wettermark, B.2    Lundberg, M.3    Pettersson, H.4    Von Bahr, C.5    Eliasson, E.6
  • 21
    • 56749152357 scopus 로고    scopus 로고
    • Cohort study examining tamoxifen adherence and its relationship to mortality in women with breast cancer
    • McCowan C, Shearer J, Donnan PT, Dewar JA, Crilly M, Thompson AM, Fahey TP (2008) Cohort study examining tamoxifen adherence and its relationship to mortality in women with breast cancer. Br J Cancer 99:1763-1768
    • (2008) Br J Cancer , vol.99 , pp. 1763-1768
    • McCowan, C.1    Shearer, J.2    Donnan, P.T.3    Dewar, J.A.4    Crilly, M.5    Thompson, A.M.6    Fahey, T.P.7
  • 22
    • 43249126529 scopus 로고    scopus 로고
    • Insight into barriers against optimal adherence to oral hormonal therapy in women with breast cancer
    • Kirk MC, Hudis CA (2008) Insight into barriers against optimal adherence to oral hormonal therapy in women with breast cancer. Clin Breast Cancer 8:155-161
    • (2008) Clin Breast Cancer , vol.8 , pp. 155-161
    • Kirk, M.C.1    Hudis, C.A.2
  • 23
    • 0037441639 scopus 로고    scopus 로고
    • Nonadherence to adjuvant tamoxifen therapy in women with primary breast cancer
    • Partridge AH, Wang PS, Winer EP, Avorn J (2003) Nonadherence to adjuvant tamoxifen therapy in women with primary breast cancer. J Clin Oncol 21:602-606
    • (2003) J Clin Oncol , vol.21 , pp. 602-606
    • Partridge, A.H.1    Wang, P.S.2    Winer, E.P.3    Avorn, J.4
  • 24
    • 0023922814 scopus 로고
    • Identi fi cation of 4-hydroxy-N-desmethyltamoxifen as a metabolite of tamoxifen in human bile
    • Lien EA, Solheim E, Kvinnsland S, Ueland PM (1988) Identi fi cation of 4-hydroxy-N-desmethyltamoxifen as a metabolite of tamoxifen in human bile. Cancer Res 48:2304-2308
    • (1988) Cancer Res , vol.48 , pp. 2304-2308
    • Lien, E.A.1    Solheim, E.2    Kvinnsland, S.3    Ueland, P.M.4
  • 25
    • 33645224920 scopus 로고    scopus 로고
    • Liquid chromatography-mass spectrometry/mass spectrometry method development for drug metabolism studies: Examining lipid matrix ionization effects in plasma
    • Little JL, Wempe MF, Buchanan CM (2006) Liquid chromatography-mass spectrometry/mass spectrometry method development for drug metabolism studies: examining lipid matrix ionization effects in plasma. J Chromatogr B Analyt Technol Biomed Life Sci 833:219-230
    • (2006) J Chromatogr B Analyt Technol Biomed Life Sci , vol.833 , pp. 219-230
    • Little, J.L.1    Wempe, M.F.2    Buchanan, C.M.3
  • 26
    • 0021273172 scopus 로고
    • Some chemical and biochemical aspects of liver microsomal metabolism of tamoxifen
    • Ruenitz PC, Bagley JR, Pape CW (1984) Some chemical and biochemical aspects of liver microsomal metabolism of tamoxifen. Drug Metab Dispos 12:478-483
    • (1984) Drug Metab Dispos , vol.12 , pp. 478-483
    • Ruenitz, P.C.1    Bagley, J.R.2    Pape, C.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.