Prevention of renal ischemia-reperfusion injury by short hairpin RNA of endothelin A receptor in a rat model

Experimental Biology and Medicine

Volumn 237, Issue 8, 2012, Pages 894-902

  Jia, Yichen ^a   Zhao, Zitong ^a   Xu, Ming ^a   Zhao, Tian ^a   Qiu, Yongyin ^a   Ooi, Yitreen ^a   Yang, Bin ^b,c,d   Rong, Ruiming ^a   Zhu, Tongyu ^a  

^a FUDAN UNIVERSITY   (China)

^b Transplant group   (United Kingdom)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

^d NANTONG UNIVERSITY   (China)

Author keywords

Endothelin A receptor; Ischemia reperfusion injury; Kidney; RNA interference

Indexed keywords

CREATININE; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; PHOSPHATE BUFFERED SALINE; PLASMID VECTOR; SHORT HAIRPIN RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CLAMP; ARTICLE; BLOOD SAMPLING; CELL LINE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CYTOKINE PRODUCTION; GENE EXPRESSION; GENE SILENCING; KIDNEY FUNCTION; KIDNEY ISCHEMIA; KIDNEY PARENCHYMA; KIDNEY STRUCTURE; KIDNEY VEIN; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; RNA SEQUENCE; UREA NITROGEN BLOOD LEVEL;

ANIMALS; BIOLOGICAL AGENTS; CYTOKINES; GENE EXPRESSION PROFILING; INJECTIONS, INTRAVENOUS; KIDNEY; MALE; PLASMIDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; REPERFUSION INJURY; RNA, SMALL INTERFERING;

EID: 84865321756     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1258/ebm.2012.011368     Document Type: Article

References (32)

1. Halloran PF. Immunosuppressive drugs for kidney transplantation. N Engl J Med 2004;351:2715-29.
2. Bonventre JV, Zuk A. Ischemic acute renal failure: an inflammatory disease? Kidney Int 2004;66:480-5.
3. Brodsky SV, Yamamoto T, Tada T, Kim B, Chen J, Kajiya F, Goligorsky MS. Endothelial dysfunction in ischemic acute renal failure: rescue by transplanted endothelial cells. Am J Physiol Renal Physiol 2002;282:F1140-9.
4. McCaffrey AP, Meuse L, Pham TT, Conklin DS, Hannon GJ, Kay MA. RNA interference in adult mice. Nature 2002;418:38-9.
5. Zheng X, Zhang X, Feng B, Sun H, Suzuki M, Ichim T, Kubo N, Wong A, Min LR, Budohn ME, Garcia B, Jevnikar AM, Min WP. Gene silencing of complement C5a receptor using siRNA for preventing ischemia/ reperfusion injury. Am J Pathol 2008;173:973-80.
6. Zheng X, Feng B, Chen G, Zhang X, Li M, Sun H, Liu W, Vladau C, Liu R, Jevnikar AM, Garcia B, Zhong R, Min WP. Preventing renal ischemia-reperfusion injury using small interfering RNA by targeting complement 3 gene. Am J Transplant 2006;6:2099-108.
7. Feng B, Chen G, Zheng X, Sun H, Zhang X, Zhang ZX, Xiang Y, Ichim TE, Garcia B, Luke P, Jevnikar AM, Min WP. Small interfering RNA targeting RelB protects against renal ischemia-reperfusion injury. Transplantation 2009;87:1283-9.
8. Yang B, Elias JE, Bloxham M, Nicholson ML. Synthetic small interfering RNA down-regulates caspase-3 and affects apoptosis, IL-1 beta, and viability of porcine proximal tubular cells. J Cell Biochem 2011;112:1337-47.
9. Yang B, Hosgood SA, Nicholson ML. Naked small interfering RNA of caspase-3 in preservation solution and autologous blood perfusate protects isolated ischemic porcine kidneys. Transplantation 2011;91:501-7.
10. Tomasoni S, Azzollini N, Casiraghi F, Capogrossi MC, Remuzzi G, Benigni A. CTLA4Ig gene transfer prolongs survival and induces donor-specific tolerance in a rat renal allograft. J Am Soc Nephrol 2000;11:747-52.
11. Kato H, Ritter T, Ke B, Murakami M, Kusano M, Busuttil RW, Kupiec-Weglinski JW. Adenovirus-mediated gene transfer of IL-4 prolongs rat renal allograft survival and inhibits the p21(ras)-activation pathway. Transplant Proc 2000;32:245-6.
12. Carr MW, Roth SJ, Luther E, Rose SS, Springer TA. Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc Natl Acad Sci USA 1994;91:3652-6.
13. Wolpe SD, Sherry B, Juers D, Davatelis G, Yurt RW, Cerami A. Identification and characterization of macrophage inflammatory protein 2. Proc Natl Acad Sci USA 1989;86:612-6.
14. Maruyama H, Higuchi N, Nishikawa Y, Hirahara H, Iino N, Kameda S, Kawachi H, Yaoita E, Gejyo F, Miyazaki J. Kidney-targeted naked DNA transfer by retrograde renal vein injection in rats. Hum Gene Ther 2002;13:455-68.
15. Maruyama H, Higuchi N, Kameda S, Nakamura G, Iguchi S, Miyazaki J, Gejyo F. Rat kidney-targeted naked plasmid DNA transfer by retrograde injection into the renal vein. Mol Biotechnol 2004;27:23-31.
16. Kita J, Kobayashi E, Hishinuma A, Kaneda Y. Genetic modification of cold-preserved renal grafts using HSP70 or bcl-2 HVJ-liposome method. Transpl Immunol 2003;11:7-14.
17. Eltzschig HK, Carmeliet P. Hypoxia and inflammation. N Engl J Med 2011;364:656-65.
18. Sharfuddin AA, Molitoris BA. Pathophysiology of ischemic acute kidney injury. Nat Rev Nephrol 2011;7:189-200.
19. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998;391:806-11.
20. Hamilton AJ, Baulcombe DC. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science 1999;286:950-2.
21. Siomi H, Siomi MC. On the road to reading the RNA-interference code. Nature 2009;457:396-404.
22. Vermeulen A, Behlen L, Reynolds A, Wolfson A, Marshall WS, Karpilow J, Khvorova A. The contributions of dsRNA structure to Dicer specificity and efficiency. RNA 2005;11:674-82.
23. Castanotto D, Rossi JJ. The promises and pitfalls of RNA-interferencebased therapeutics. Nature 2009;457:426-33.
24. Yin M, Wheeler MD, Connor HD, Zhong Z, Bunzendahl H, Dikalova A, Samulski RJ, Schoonhoven R, Mason RP, Swenberg JA, Thurman RG. Cu/Zn-superoxide dismutase gene attenuates ischemia-reperfusion injury in the rat kidney. J Am Soc Nephrol 2001;12:2691-700.
25. Gottmann U, van der Woude FJ, Braun C. Endothelin receptor antagonists: a new therapeutic option for improving the outcome after solid organ transplantation? Curr Vasc Pharmacol 2003;1:281-99.
26. Ray A, Hegde LG, Chugh A, Gupta JB. Endothelin-receptor antagonists: current and future perspectives. Drug Discov Today 2000;5:455-64.
27. Krum H, Viskoper RJ, Lacourciere Y, Budde M, Charlon V. The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. Bosentan Hypertension Investigators. N Engl J Med 1998;338:784-90.
28. Louis A, Cleland JG, Crabbe S, Ford S, Thackray S, Houghton T, Clark A. Clinical trials update: CAPRICORN, COPERNICUS, MIRACLE, STAF, RITZ-2, RECOVER and RENAISSANCE and cachexia and cholesterol in heart failure. Highlights of the scientific sessions of the American College of Cardiology, 2001. Eur J Heart Fail 2001;3:381-7.
29. McMurray J, Pfeffer MA. New therapeutic options in congestive heart failure: part I. Circulation 2002;105:2099-106.
30. Grassi G. Selective endothelin receptor blockade in resistant hypertension: results of the DORADO trial. Expert Opin Pharmacother 2011;12:153-5.
31. Remuzzi G, Perico N, Benigni A. New therapeutics that antagonize endothelin: promises and frustrations. Nat Rev Drug Discov 2002;1:986-1001.
32. Boulanger C, Luscher TF. Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide. J Clin Invest 1990;85:587-90.