Combination of N-methylisatin-β-thiosemicarbazone derivative (SCH16) with ribavirin and mycophenolic acid potentiates the antiviral activity of SCH16 against Japanese encephalitis virus in vitro

Letters in Applied Microbiology

Volumn 55, Issue 3, 2012, Pages 234-239

  Sebastian, L ^a   Desai, A ^a   Yogeeswari, P ^b   Sriram, D ^b   Madhusudana, S N ^a   Ravi, V ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

^b BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Combinations; MIBT derivative; Mycophenolic acid; Ribavirin

Indexed keywords

AMIDES; ANTIVIRAL AGENTS; DRUG INTERACTIONS; PHENOLS;

ANTIVIRAL ACTIVITIES; COMBINATION; DRUG COMBINATIONS; IN-VITRO; MIBT DERIVATIVE; MYCOPHENOLIC ACIDS; PENTOXIFYLLINE; RIBAVIRIN; THIOSEMICARBAZONES; VITRO AND IN VIVO;

VIRUSES;

METISAZONE; MYCOPHENOLIC ACID; PENTOXIFYLLINE; RIBAVIRIN;

ANTAGONISM; CHEMICAL COMPOSITION; DRUG; TOXICITY; VIRUS;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; JAPANESE ENCEPHALITIS VIRUS; MOSQUITO; NONHUMAN; SWINE; VIRUS INHIBITION; VIRUS REPLICATION;

JAPANESE ENCEPHALITIS VIRUS;

EID: 84865320380     PISSN: 02668254     EISSN: 1472765X     Source Type: Journal    
DOI: 10.1111/j.1472-765X.2012.03282.x     Document Type: Article

References (23)

1. Baba, M., Ito, M., Shigeta, S. and de Clercq, E. (1984) Synergistic antiviral effects of anti-herpes compounds and human Leukocyte interferon on Varicella-Zoster virus in vitro. Antimicrob Agents Chemother 25, 515-517.
2. Borroto-Esoda, K., Myrick, F., Feng, J., Jeffrey, J. and Furman, P. (2004) In vitro combination of amdoxovir and inosine monophosphate dehydrogenase inhibitors mycophenolic acid and ribavirin demonstrates potent activity against wild-type and drug-resistant variants of human immunodeficiency virus type 1. Antimicrob Agents Chemother 48, 4387-4394.
3. Briolant, S., Garin, D., Scaramozzino, N., Jouan, A. and Crance, J.M. (2004) In vitro inhibition of Chikungunya and Semliki forest virus replication by antiviral compounds: Synergistic effect of interferon-α and ribavirin combination. Antiviral Res 61, 111-117.
4. Chang, J., Schul, W., Butters, T.D., Yip, A., Liu, B., Goh, A., Lakshminarayana, S.B., Alonzi, D. et al. (2011) Combination of alpha-glucosidase inhibitor and ribavirin for the treatment of Dengue virus infection in vitro and in vivo. Antiviral Res 89, 26-34.
5. Coen, D.M. (1991) The implications of resistance to antiviral agents for herpes virus drug targets and drug therapy. Antiviral Res 15, 287-300.
6. Crance, J.M., Scarmozzino, N., Jouan, A. and Garin, D. (2003) Interferon, Ribavirin, 6-azauridine and Glycyrrhizin: antiviral compounds active against pathogenic Flavivirus. Antiviral Res 57, 73-79.
7. Delaney, W.E. IV, Huiling, Y., Miller, M.D., Gibbs, C.S. and Xion, S. (2004) Combinations of adefovir with nucleoside analogs produce additive antiviral effects against hepatitis B virus in vitro. Antimicrob Agents Chemother 48, 3702-3710.
8. Diamond, M.S., Zachariah, M. and Harris, E. (2002) Mycophenolic acid inhibits Dengue virus infection by preventing replication of viral RNA. Virology 304, 211-221.
9. Easmon, J., Heinisch, G., Holzer, W. and Rosenwirth, B. (1992) Novel thiosemicarbazones derived from formyl and acyldiazines: synthesis, effects on cell proliferation, and synergism with antiviral agents. J Med Chem 21, 3288-3296.
10. Easterbrook, K.B. (1962) Interference with the maturation of Vaccinia virus by isatin-β-thiosemicarbazone. Virology 17, 245-251.
11. Elion, G.B., Singer, S. and Hitchings, S. (1954) Antagonists of nucleic acid derivatives. VIII. Synergism in combination of biochemically related anti-metabolites. J Biol Chem 208, 477-488.
12. Feng, J.Y., Ly, J.K., Myrick, F., Goodman, D., White, K.L., Svarovskaia, E.S., Borroto-Esoda, K. and Miller, M.D. (2009) Triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: mechanism of action study. Retrovirology 6, 44.
13. Gosh, D. and Basu, A. (2009) Japanese encephalitis: a pathological and clinical perspective. PLoS Negl Trop Dis 3, e437.
14. Huh, P.W., Kotasek, D., Jacob, H.S., Vercellotti, G.M. and Hammerschimidt, D.E. (1985) Mechanism of action of pentoxifylline in peripheral vascular disease: inhibition of platelet and granulocyte responsiveness. Clin Res 33, 866-878.
15. Leyssen, P., Balzarini, J., De Clercq, E. and Neyts, J. (2005) The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against Flaviviruses and Paramyxoviruses is mediated by inhibition of IMP dehydrogenase. J Virol 79, 1943-1947.
16. Prichard, M.N., Prichard, L.E. and Shipman, C. (1993) Strategic design and three-dimensional analysis of antiviral drug combinations. Antimicrob Agents Chemother 37, 540-545.
17. Raung, S.L., Chen, C.J., Kuo, M.D. and Wang, Y.M. (2002) Suppression of Japanese encephalitis virus infection by non-steroidal anti-inflammatory drugs. J Gen Virol 83, 1897-1905.
18. Sebastian, L., Desai, A., Madhusudana, S.N., Yogeeswari, Y., Sriram, D. and Ravi, V. (2008) N-methylisatin-β-thiosemicarbazone derivative (SCH 16) is an inhibitor of Japanese encephalitis virus infection in vitro and in vivo. Virol J 5, 64.
19. Sebastian, L., Desai, A., Madhusudana, S.N. and Ravi, V. (2009) Pentoxifylline inhibits replication of Japanese encephalitis virus: a comparative study with ribavirin. Int J Antimicrob Agents 33, 168-173.
20. Sebastian, L., Desai, A., Madhusudana, S.N. and Ravi, V. (2011) Mycophenolic acid inhibits replication of Japanese encephalitis virus. Chemotherapy 57, 56-61.
21. Takhampunya, R., Cameron, C.E., Ubol, S., Houng, H.S. and Padmanabhan, R. (2006) Inhibition of dengue virus replication by mycophenolic acid and ribavirin. J Gen Virol 87, 1947-1952.
22. Tamm, I.J. and Eggers, H.J. (1965) Chemical approaches to selective inhibition of viral multiplication. Calif Med 103, 305-309.
23. Wu, S.F., Lee, C.J., Lia, C.L., Dwek, R.A., Zitzmann, N. and Lin, Y.L. (2002) Antiviral effects of an iminosugar derivative on Flavivirus infections. J Virol 76, 3596-3604.