Characterization of surfactants in an oil-in-water emulsion-based vaccine adjuvant using MS and HPLC-MS: Structural analysis and quantification

International Journal of Pharmaceutics

Volumn 436, Issue 1-2, 2012, Pages 233-239

  Cotte, Jean François ^a   Sonnery, Sylvain ^a   Martial, Fabien ^a   Dubayle, Jean ^a   Dalençon, François ^a   Haensler, Jean ^a   Adam, Olivier ^a  

^a SANOFI PASTEUR   (France)

Author keywords

AF03; Cetheareth 12; HPLC; Mass spectrometry; Quantification; Sorbitan oleate

Indexed keywords

CETHEARETH 12; ETHYLENE OXIDE; FATTY ALCOHOL; LINOLEIC ACID; OLEIC ACID; PALMITIC ACID; SORBITAN OLEATE; SURFACTANT; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; EMULSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION TRAP MASS SPECTROMETRY; LIMIT OF QUANTITATION; PRIORITY JOURNAL; QUALITY CONTROL;

ADJUVANTS, PHARMACEUTIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EMULSIONS; HEXOSES; MOLECULAR STRUCTURE; OILS; POLYETHYLENE GLYCOLS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SURFACE-ACTIVE AGENTS; VACCINES; WATER;

EID: 84865294719     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.06.018     Document Type: Article

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